Laila Ahmed Rashed
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View article: <scp>PD</scp> ‐1/ <scp>PD</scp> ‐ <scp>L1</scp> Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation
<span>PD</span> ‐1/ <span>PD</span> ‐ <span>L1</span> Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation Open
Vitiligo, a chronic autoimmune disorder characterized by progressive melanocyte destruction, remains challenging to treat due to an incomplete understanding of underlying immune mechanisms. Recent clinical observations from cancer immunoth…
View article: The diagnostic utility of miRNA21 in systemic sclerosis
The diagnostic utility of miRNA21 in systemic sclerosis Open
Objective. Systemic sclerosis (SSc) is a multisystem autoimmune disease of heterogeneous pathogenesis, including vascular, immunologic, genetic, epigenetic, and environmental factors. Progressive fibrosis is the hallmark of SSc. Intense re…
View article: Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet
Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet Open
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastrointestinal dysfunction. The study design included four groups, each consisting of six rats: the control group was fe…
View article: Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression
Melatonin promoted the therapeutic potential of cisplatin in a rat model of hepatocellular carcinoma: COX-2 and MDM2/p53/miR-155 modulation associated with cytoprotection and tumour regression Open
Globally, hepatocellular carcinoma (HCC) presents a clinical and financial burden, as it is often diagnosed at a later stage. Cisplatin is one of the most commonly used chemotherapeutics for treating various types of solid tumours; however…
View article: Amelioration of gut dysbiosis-induced cognitive deterioration by repeated administration of human clostridium butyricum: targeting intestinal and blood–brain barrier
Amelioration of gut dysbiosis-induced cognitive deterioration by repeated administration of human clostridium butyricum: targeting intestinal and blood–brain barrier Open
Background Disturbed intestinal integrity and increased permeability are linked to dysbiosis. This disruption involves GIT-related and unrelated diseases, such as neurological diseases. Intake of a high-fat diet (HFD) leads to an imbalance…
View article: Evaluation of ascitic lactoferrin as a diagnostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis
Evaluation of ascitic lactoferrin as a diagnostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis Open
Background The optimal cut-off level of lactoferrin in ascitic fluid is debatable for identification of spontaneous bacterial peritonitis (SBP). This study aimed to detect the cut-off level of lactoferrin in ascitic fluid and its role in t…
View article: Ferrostatin-1 Partially Suppressed the Anti-Fibrotic Actions of Thymoquinone in a Rat Model of Cholestasis-Induced Liver Injury
Ferrostatin-1 Partially Suppressed the Anti-Fibrotic Actions of Thymoquinone in a Rat Model of Cholestasis-Induced Liver Injury Open
View article: Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus
Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus Open
View article: Assessment of programmed cell death 1 and its programmed cell death ligand 1 levels in vitiligo
Assessment of programmed cell death 1 and its programmed cell death ligand 1 levels in vitiligo Open
Background Programmed cell death 1 (PD-1) is a cell surface protein that serves as an immune checkpoint in conjunction with its two ligands, PD-L1 and PD-L2. Recently, there has been a lot of interest in the role of the PD-1/PD-L1 pathway …
View article: Synergistic Effect of Caloric Restriction and Cyclooxygenase-2 Inhibitor &#8220;Celecoxib&#8221; Against IGFs/COX-2 Mediating Chemically Induced Hepatocellular Carcinoma in Rats
Synergistic Effect of Caloric Restriction and Cyclooxygenase-2 Inhibitor “Celecoxib” Against IGFs/COX-2 Mediating Chemically Induced Hepatocellular Carcinoma in Rats Open
View article: Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity
Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity Open
View article: Severe carbohydrate restriction augments the antiproliferative effect of hormonal therapy in a murine model of Ehrlich breast adenocarcinoma: histological and immunohistochemical investigations
Severe carbohydrate restriction augments the antiproliferative effect of hormonal therapy in a murine model of Ehrlich breast adenocarcinoma: histological and immunohistochemical investigations Open
Background Malignant tumors of the breast are the most diagnosed cancers in females globally. Recent evidence suggests that carbohydrate restriction (CR), especially ketogenic diets, has become a potential treatment approach for many malig…
View article: Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet’s disease patients: a preliminary report
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet’s disease patients: a preliminary report Open
View article: Correction: Amin et al. Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone. Brain Sci. 2020, 10, 193
Correction: Amin et al. Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone. Brain Sci. 2020, 10, 193 Open
In the original publication [...]
View article: Clinical study of Wnt inhibitory factor-1 expression and its association with disease severity in non-segmental vitiligo
Clinical study of Wnt inhibitory factor-1 expression and its association with disease severity in non-segmental vitiligo Open
Background Vitiligo is classified as an acquired chronic depigmentation disorder that includes the destruction of epidermal melanocytes. It affects 0.5–1% of the population all over the world. Wnt signaling pathway is vital in melanocytes …
View article: Metformin and intermittent fasting mitigate high fat-fructose diet-induced liver and skeletal muscle injury through upregulation of mitophagy genes in rats
Metformin and intermittent fasting mitigate high fat-fructose diet-induced liver and skeletal muscle injury through upregulation of mitophagy genes in rats Open
Background High fat-fructose diet is a proinflammatory diet that increases risk of hepatocytes and myocytes steatosis and fibrosis. Finding anti-inflammatory strategies to fight these harmful effects is paid attention to nowadays. This stu…
View article: Empagliflozin mitigates methotrexate-induced nephrotoxicity in male albino rats: insights on the crosstalk of AMPK/Nrf2 signaling pathway
Empagliflozin mitigates methotrexate-induced nephrotoxicity in male albino rats: insights on the crosstalk of AMPK/Nrf2 signaling pathway Open
Background The anti-diabetic drug, empagliflozin (EMPA), has many pleiotropic actions and is challenged recently to possess renoprotective properties. This renoprotective potential is proposed to be mediated via the activation of AMP-activ…
View article: Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats
Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats Open
Background Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in th…
View article: Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo
Level of long noncoding RNA taurine upregulated gene 1 after narrow band-ultraviolet B phototherapy in vitiligo Open
Background Vitiligo is a skin disease that is characterized by depigmenting lesions as a result of melanocytes destruction. Long noncoding Taurine upregulated gene 1 (lnc TUG-1) is one of the long noncoding RNA (lnc RNA) family members. Th…
View article: Seminal Endoglin in infertile men with varicocele, a cohort study
Seminal Endoglin in infertile men with varicocele, a cohort study Open
Background Varicocele is considered a common and correctable cause of male infertility. This is established by the improvement of sperm parameters after surgical correction. Endoglin (Eng) is presented in two forms, a membrane and soluble …
View article: Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model
Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model Open
Background Streptozotocin (STZ) is a glucose analogue commonly used for inducing diabetes in experimental animals. This study is intended to investigate the ability of captopril (Cap) pretreatment to augment STZ-induced diabetogenic effect…
View article: Assessment of PD-1 and PD-L1 tissue expression levels in lichen planus patients: a case–control study
Assessment of PD-1 and PD-L1 tissue expression levels in lichen planus patients: a case–control study Open
View article: Evaluation of skeletal muscle function in male rats with doxorubicin-induced myopathy following various exercise techniques: the significant role of glucose transporter 4
Evaluation of skeletal muscle function in male rats with doxorubicin-induced myopathy following various exercise techniques: the significant role of glucose transporter 4 Open
A common anthracycline antibiotic used to treat cancer patients is doxorubicin (DOX). One of the effects of DOX therapy is skeletal muscle fatigue. Our goal in this research was to study the beneficial effect of exercise on DOX-induced dam…
View article: The Potential Association Between microRNA 135-5P and p62 and Their Effect on NRF2 Pathway in Multiple Sclerosis
The Potential Association Between microRNA 135-5P and p62 and Their Effect on NRF2 Pathway in Multiple Sclerosis Open
This study reveals a potential association between miRNA 135-5p and p62, indicating their role in the pathogenesis of MS. Results suggest that miRNA 135-5p and p62 may influence inflammation and oxidative stress in MS through the NRF2 path…
View article: Glutamate as a new path in discrimination between neuromyelitis optica spectrum disorder and multiple sclerosis
Glutamate as a new path in discrimination between neuromyelitis optica spectrum disorder and multiple sclerosis Open
Background Neuromyelitis optica spectrum disorder (NMOSD) used to be considered as a variant of multiple sclerosis (MS), however the recent detection of a highly specific serum biomarkers for NMOSD have made clear that NMOSD is a condition…
View article: Nourin miRNAs: novel biomarkers highly expressed in unstable angina patients with normal ECG and negative hs-troponin and dropped post percutaneous coronary intervention
Nourin miRNAs: novel biomarkers highly expressed in unstable angina patients with normal ECG and negative hs-troponin and dropped post percutaneous coronary intervention Open
Background We recently reported that Nourin-dependent miR-137 and miR-106b can identify reversible myocardial ischemia in chest pain patients with a confirmed diagnosis of chronic stable chronic artery disease (CAD) and unstable angina (UA…
View article: <scp>SGLT</scp>‐2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat <scp>PCOS</scp> model
<span>SGLT</span>‐2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat <span>PCOS</span> model Open
Polycystic ovary syndrome (PCOS) is a common endocrine, reproductive, and metabolic disorder affecting females. The management of PCOS is challenging and current interventions are not enough to deal with all consequences of this syndrome. …
View article: Melatonin Mitigates the Progression of Chemically Induced Hepatocellular Carcinoma in Rats via Targeting Wnt/Β-Catenin Pathway, and Small Noncoding miR-let-7b
Melatonin Mitigates the Progression of Chemically Induced Hepatocellular Carcinoma in Rats via Targeting Wnt/Β-Catenin Pathway, and Small Noncoding miR-let-7b Open
Melatonin exerted hepatic immunomodulating changes, in addition to proapoptotic and antiangiogenic effects, illustrated by increased IL-2, caspase-3, and decreased VEGF levels, respectively. Moreover, the use of melatonin during hepatocarc…
View article: Amelioration of rotenone-induced Parkinson's disease; comparing therapeutic role of erythropoietin versus low-level laser activation of mesenchymal stem cells (an in-vivo and in-vitro study)
Amelioration of rotenone-induced Parkinson's disease; comparing therapeutic role of erythropoietin versus low-level laser activation of mesenchymal stem cells (an in-vivo and in-vitro study) Open
Parkinson's disease (PD), the second common neurodegenerative disease, is characterized by the loss of the dopaminergic neurons in the substantia nigra (SN). Because of L-dopa's side effects, new therapeutic methods were considered such as…
View article: Evaluating the hepatotoxic versus the nephrotoxic role of iron oxide nanoparticles: One step forward into the dose-dependent oxidative effects
Evaluating the hepatotoxic versus the nephrotoxic role of iron oxide nanoparticles: One step forward into the dose-dependent oxidative effects Open
The present study has been designed to detect the dose-dependent effect of iron oxide nanoparticles (IONPs) on the liver and kidney of rats by evaluating three different doses 30, 300, 1000 mg/kg/day IONPs for 28 days. Forty rats were divi…