Laila Salmen Espíndola
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View article: Effects of Long‐Term Nutrient Addition on Leaf Metabolites, Herbivory, and Mycorrhizal Spores Associated With a Savannah Woody Species
Effects of Long‐Term Nutrient Addition on Leaf Metabolites, Herbivory, and Mycorrhizal Spores Associated With a Savannah Woody Species Open
Given the importance of soil conditions for ecosystem functioning, fertilisation experiments are a valuable tool for assessing how systems respond to changes in soil properties. However, the effects of changes in nutrient availability on m…
View article: Neuropsychomotor Development of Children Exposed to SARS-CoV-2 in Utero During COVID-19 Pandemic
Neuropsychomotor Development of Children Exposed to SARS-CoV-2 in Utero During COVID-19 Pandemic Open
Introduction: Little is known about the effects of intrauterine exposure to SARS-CoV-2, especially on growth and neurodevelopment in children. Objective: We wished to verify the effect of intrauterine exposure to SARS-CoV-2 on neurological…
View article: Structure‐Based Screening of Amides with Potential to Overcome <i>Aedes aegypti</i> Insecticide Resistance
Structure‐Based Screening of Amides with Potential to Overcome <i>Aedes aegypti</i> Insecticide Resistance Open
Several natural and synthetic compounds applied as insecticides are amide derivatives. Within the broad spectrum of insecticidal activity of this class of compounds, the activity against Aedes aegypti stands out. The aim of this study was …
View article: The dialog between mother and newborn: insights from immune mediator crosstalk elicited by antenatal SARS-COV-2 exposure
The dialog between mother and newborn: insights from immune mediator crosstalk elicited by antenatal SARS-COV-2 exposure Open
Goal The present study intended to evaluate whether the profile of soluble immune mediators observed in cord blood samples resembles the pattern identified for mother serum samples. Methods For this purpose, parallel analysis of chemokines…
View article: Clinical characteristic and outcomes of pregnant women with COVID‐19: The PROUDEST prospective cohort study
Clinical characteristic and outcomes of pregnant women with COVID‐19: The PROUDEST prospective cohort study Open
The present study intended to characterize the clinical features and outcomes of SARS-CoV-2 infection at distinct pregnancy trimesters. A total of 260 pregnant women with SARS-CoV-2 infection at any pregnancy trimester were enrolled in a p…
View article: Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development
Cenostigma bracteosum Hydroethanolic Extract: Chemical Profile, Antibacterial Activity, Cytotoxicity, and Gel Formulation Development Open
Background:Cenostigma bracteosum (Tul.) Gagnon & G.P. Lewis (Fabaceae), popularly known as “catingueira”, is a plant widely distributed in the Caatinga biome, which comprises 11% of the Brazilian territory. While this species is of interes…
View article: POS1174 ELEVATED PREVALENCE OF TRYPANOSOMA CRUZI INFECTION IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS UNDERGOING IMMUNOSUPPRESSIVE THERAPY: A CROSS-SECTIONAL STUDY
POS1174 ELEVATED PREVALENCE OF TRYPANOSOMA CRUZI INFECTION IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS UNDERGOING IMMUNOSUPPRESSIVE THERAPY: A CROSS-SECTIONAL STUDY Open
View article: Differential Circulating Levels of miR-92a in Patients with SARS-CoV-2 Infection
Differential Circulating Levels of miR-92a in Patients with SARS-CoV-2 Infection Open
Aim: The aim of the present study was to analyze a panel of immune-related miRNAs found in the respiratory tract among patients with symptomatic COVID-19. Method: This is a cross-sectional analysis on the total levels of selected miRNAs as…
View article: Characterization of Larvicidal Diterpene Resin Acids in <scp> <i>Melipona quadrifasciata</i> </scp> Geopropolis via LC‐ESI‐MS/MS, GC–MS and Computational Analysis
Characterization of Larvicidal Diterpene Resin Acids in <span> <i>Melipona quadrifasciata</i> </span> Geopropolis via LC‐ESI‐MS/MS, GC–MS and Computational Analysis Open
Rationale Dengue, an arboviral disease transmitted by the Aedes aegypti mosquito, is a major global public health problem challenge. Insecticides based on natural products can provide a good alternative to synthetic agents, as they are saf…
View article: Green Synthesis of Silver Nanoparticles Using Paullinia cupana Kunth Leaf Extract Collected in Different Seasons: Biological Studies and Catalytic Properties
Green Synthesis of Silver Nanoparticles Using Paullinia cupana Kunth Leaf Extract Collected in Different Seasons: Biological Studies and Catalytic Properties Open
Background: Paullinia cupana Kunth, popularly known as guarana, a native Amazonian shrub cultivated by the Sateré-Mawé ethnic group, has been used in traditional medicine for various purposes, including stimulant and therapeutic actions, d…
View article: Natural resources used in the traditional medicine of the Marinaú community, Caxiuanã forest, Brazil
Natural resources used in the traditional medicine of the Marinaú community, Caxiuanã forest, Brazil Open
Background The diversity of Conservation Units in Brazil, ranging from Strict Protection areas like National Parks to Sustainable Use areas such as National Forests, supports the coexistence of human populations with extensive traditional …
View article: Nanoemulsions and Solid Microparticles Containing Pentyl Cinnamate to Control Aedes aegypti
Nanoemulsions and Solid Microparticles Containing Pentyl Cinnamate to Control Aedes aegypti Open
The Aedes aegypti mosquito is a vector of severe diseases with high morbidity and mortality rates. The most commonly used industrial larvicides have considerable toxicity for non-target organisms. This study aimed to develop and evaluate l…
View article: Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy
Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy Open
Background SARS-CoV-2 infection and perinatal neurologic outcomes are still not fully understood. However, there is recent evidence of white matter disease and impaired neurodevelopment in newborns following maternal SARS-CoV-2 infection. …
View article: Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study
Panoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent COVID-19: an exploratory study Open
Introduction SARS-CoV-2 infection during pregnancy can induce changes in the maternal immune response, with effects on pregnancy outcome and offspring. This is a cross-sectional observational study designed to characterize the immunologica…
View article: Larvicidal activity of thiazolidinedione derivatives against Aedes aegypti larvae and toxicological studies with zebrafish embryos
Larvicidal activity of thiazolidinedione derivatives against Aedes aegypti larvae and toxicological studies with zebrafish embryos Open
BACKGROUND: Diseases caused by arboviruses are currently a worldwide public health problem. These diseases have the Aedes aegypti mosquito as the main transmission vector, and the main strategy to combat their spread is the interruption of…
View article: Larvicidal activity of thiazolidinedione derivatives against Aedes aegypti larvae and toxicological studies with zebrafish embryos
Larvicidal activity of thiazolidinedione derivatives against Aedes aegypti larvae and toxicological studies with zebrafish embryos Open
BACKGROUND: Diseases caused by arboviruses are currently a worldwide public health problem. These diseases have the Aedes aegypti mosquito as the main transmission vector, and the main strategy to combat their spread is the interruption of…
View article: A neolignan from Connarus tuberosus as an allosteric GABAA receptor modulator at the neurosteroid binding site
A neolignan from Connarus tuberosus as an allosteric GABAA receptor modulator at the neurosteroid binding site Open
In a screening of a small library of extracts from plants of the Amazonian and Cerrado biomes, a hexane extract of Connarus tuberosus roots was found to significantly potentiate the GABA induced fluorescence in a fluorescence (FLIPR) assay…
View article: Continuous Flow Photochemical Synthesis of 3-Methyl-4-arylmethylene Isoxazole-5(4H)-ones through Organic Photoredox Catalysis and Investigation of Their Larvicidal Activity
Continuous Flow Photochemical Synthesis of 3-Methyl-4-arylmethylene Isoxazole-5(4H)-ones through Organic Photoredox Catalysis and Investigation of Their Larvicidal Activity Open
Isoxazole-5(4H)-ones are heteropentacycle compounds found in several bioactive molecules with pharmaceutical and agrochemical properties. A well-known multicomponent reaction between β-ketoester, hydroxylamine, and aromatic aldehydes leads…
View article: Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide
Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide Open
The Aedes aegypti mosquito significantly impacts public health, with vector control remaining the most efficient means of reducing the number of arboviral disease cases. This study screened the larvicidal and pupicidal activity of common e…
View article: Biomas brasileiros: Edição da Ciência & Cultura explora riqueza dos ecossistemas do país
Biomas brasileiros: Edição da Ciência & Cultura explora riqueza dos ecossistemas do país Open
View article: Como a Arte construiu o Brasil e a diversidade de biomas, povos e regiões: Obras celebram natureza brasileira e convidam à preservação
Como a Arte construiu o Brasil e a diversidade de biomas, povos e regiões: Obras celebram natureza brasileira e convidam à preservação Open
View article: Unbalanced networks and disturbed kinetics of serum soluble mediators associated with distinct disease outcomes in severe COVID-19 patients
Unbalanced networks and disturbed kinetics of serum soluble mediators associated with distinct disease outcomes in severe COVID-19 patients Open
The present study applied distinct models of descriptive analysis to explore the integrative networks and the kinetic timeline of serum soluble mediators to select a set of systemic biomarkers applicable for the clinical management of COVI…
View article: Negative impact of SARS-CoV-2 infection in acute coronary syndrome mortality in a Latin American cohort study
Negative impact of SARS-CoV-2 infection in acute coronary syndrome mortality in a Latin American cohort study Open
Purpose COVID-19 infection has been associated with a high risk of complications and death among patients with acute coronary syndrome (ACS). However, there is little information on the simultaneous involvement in Latin American countries.…
View article: Correction: Marine Bacteria from the Southeast Coast of Brazil as a Source of Insecticidal Compounds
Correction: Marine Bacteria from the Southeast Coast of Brazil as a Source of Insecticidal Compounds Open
View article: Impact of COVID-19 on the mental health of public university hospital workers in Brazil: A cohort-based analysis of 32,691 workers
Impact of COVID-19 on the mental health of public university hospital workers in Brazil: A cohort-based analysis of 32,691 workers Open
Background In early 2020, the COVID-19 pandemic paralyzed the world and exposed the fragility of health systems in the face of mass illness. Health professionals became protagonists, fulfilling their mission at the risk of physical and men…
View article: Evaluation of the High-Throughput Screening System for Assessing the Behavioral Response of Female Aedes aegypti to Natural Products
Evaluation of the High-Throughput Screening System for Assessing the Behavioral Response of Female Aedes aegypti to Natural Products Open
As part of an arbovirus vector control strategy, chemical control continues to be a mainstay in mitigating the burden of disease. The current arsenal of chemicals used for this purpose, however, are becoming challenged rapidly because of i…
View article: Covers
Covers Open
View article: Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils
Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils Open
Dengue is a neglected disease, present mainly in tropical countries, with more than 5.2 million cases reported in 2019. Vector control remains the most effective protective measure against dengue and other arboviruses. Synthetic insecticid…
View article: Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention
Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention Open
In patients with severe forms of COVID-19, thromboelastometry has been reported to display a hypercoagulant pattern. However, an algorithm to differentiate severe COVID-19 patients from nonsevere patients and healthy controls based on thro…
View article: In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio)
In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio) Open
The threats posed by insecticide resistance to Aedes aegypti in the context of controlling dengue have led to an urgent search for an environmentally safer alternative chemical with more effective larvicidal properties. Among many molecule…