Laiting Chan
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View article: Loss of Stat3 in Prx1 <sup>+</sup> Progenitors Impairs Molar Root Development
Loss of Stat3 in Prx1 <sup>+</sup> Progenitors Impairs Molar Root Development Open
Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating cellular proliferation, survival, apoptosis, vascularization, immune regulation, and migratory processes. Human Stat3 defic…
View article: Loss of signal transducer and activator of transcription 3 in osteoblasts impaired the bone healing in inflammatory microenvironment
Loss of signal transducer and activator of transcription 3 in osteoblasts impaired the bone healing in inflammatory microenvironment Open
Introduction This study aimed to investigate the effect of Stat3 on the osteoblast‐mediated bone healing in the inflammatory lesion. Methods The conditional knockout of Stat3 in osteoblasts (Stat3 CKO) was generated via the Cre‐loxP recomb…
View article: Loss of Stat3 in Osterix+ cells impairs dental hard tissues development
Loss of Stat3 in Osterix+ cells impairs dental hard tissues development Open
Background Mutations in the signal transducers and activators of transcription 3 ( STAT3 ) gene result in hyper-IgE syndrome(HIES), a rare immunodeficiency that causes abnormalities in immune system, bones and teeth. However, the role of S…
View article: Injectable Col-Ⅰ/CS hydrogel enhances bone regeneration in mice tibial mono-cortical defect with impaired osteogenesis
Injectable Col-Ⅰ/CS hydrogel enhances bone regeneration in mice tibial mono-cortical defect with impaired osteogenesis Open
Bone possesses the intrinsic capacity for regeneration as part of the repair process in response to injury. However, bone repairing capacity can be affected by many conditions, including genetic disorders. The development of a smart biomat…
View article: Loss of Stat3 in Osteoblasts Impaired the Bone Remodeling in Inflammatory Microenvironment
Loss of Stat3 in Osteoblasts Impaired the Bone Remodeling in Inflammatory Microenvironment Open
Introduction: Oral diseases including periodontitis, periapical periodontitis, and peri-implantitis are characterized by inflammation and loss of alveolar bone. Signal transducer and activator of transcription 3 (Stat3) involved in bone fo…
View article: Loss of Signal Transducer and Activator of Transcription 3 Impaired the Osteogenesis of Mesenchymal Progenitor Cells in Vivo and in Vitro
Loss of Signal Transducer and Activator of Transcription 3 Impaired the Osteogenesis of Mesenchymal Progenitor Cells in Vivo and in Vitro Open
Background: Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor that participates in various biologic processes. Loss of Stat3 causes hyperimmunoglobulin E syndrome, presenting with skeletal dis…
View article: Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal&nbsp;progenitor cells&nbsp;in vivo&nbsp;and&nbsp;in vitro
Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitro Open
Background Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor that participates in various biologic processes. Loss of Stat3 causes hyperimmunoglobulin E syndrome, presenting with skeletal diso…