Arun Prasath Lakshmanan
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View article: Elucidating the Probiotic Potential of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review
Elucidating the Probiotic Potential of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review Open
Gestational diabetes mellitus (GDM) affects 14% of pregnancies globally, contributing to gut microbial dysbiosis, inflammation, and insulin resistance. Probiotic supplementation with Lactobacillus and Bifidobacterium species has potential …
View article: Placental and cord blood DNA methylation in preterm birth: exploring the epigenetic role of maternal dietary protein
Placental and cord blood DNA methylation in preterm birth: exploring the epigenetic role of maternal dietary protein Open
Emerging evidence suggests that maternal nutrition plays a critical role in fetal development and pregnancy outcomes. This study explores the epigenetic link between maternal nutrition and preterm birth (PTB) by analyzing DNA methylation (…
View article: Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats
Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats Open
The role of DNA methylation (DNAm) and its modulation by dietary factors in gestational diabetes mellitus (GDM) remains underexplored, particularly in marginalized populations. This study investigates DNAm alterations in GDM‐exposed cord b…
View article: Microbial signatures and therapeutic strategies in neurodegenerative diseases
Microbial signatures and therapeutic strategies in neurodegenerative diseases Open
Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), arise from complex interactions between genetic factors, environmental exposu…
View article: Editorial: Clinical metagenomics-based diagnostics for infectious diseases
Editorial: Clinical metagenomics-based diagnostics for infectious diseases Open
Keywords: clinical metagenomics, next-generation sequencing (NGS), metagenomic NGS (mNGS), infectious diseases, diagnosis, pathogen detection
View article: Optical coherence tomography angiography: a review of the current literature
Optical coherence tomography angiography: a review of the current literature Open
This narrative review presents a comprehensive examination of optical coherence tomography angiography (OCTA), a non-invasive retinal vascular imaging technology, as reported in the existing literature. Building on the coherence tomography…
View article: The Promise of Precision Nutrition for Modulation of the Gut Microbiota as a Novel Therapeutic Approach to Acute Graft-versus-host Disease
The Promise of Precision Nutrition for Modulation of the Gut Microbiota as a Novel Therapeutic Approach to Acute Graft-versus-host Disease Open
Acute graft-versus-host disease (aGVHD) is a severe side effect of allogeneic hematopoietic stem cell transplantation (aHSCT) that has complex phenotypes and often unpredictable outcomes. The current management is not always able to preven…
View article: $\mathcal{L}_1$Quad: $\mathcal{L}_1$ Adaptive Augmentation of Geometric Control for Agile Quadrotors with Performance Guarantees
$\mathcal{L}_1$Quad: $\mathcal{L}_1$ Adaptive Augmentation of Geometric Control for Agile Quadrotors with Performance Guarantees Open
Quadrotors that can operate predictably in the presence of imperfect model knowledge and external disturbances are crucial in safety-critical applications. We present L1Quad, a control architecture that ensures uniformly bounded transient …
View article: Optical coherence tomography angiography (OCTA): A review of the current literature
Optical coherence tomography angiography (OCTA): A review of the current literature Open
OCTA is an imaging modality used in the assessment of the retinal vasculature. It operates on the principle of coherence tomography used in standard OCT with the addition of delineating the retinal vascular. This provides a modern non-inva…
View article: The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence
The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence Open
View article: Modulation of gut microbiota: The effects of a fruits and vegetables supplement
Modulation of gut microbiota: The effects of a fruits and vegetables supplement Open
The consumption of an optimal amount of fruits and vegetables is known to improve physical fitness and physiological body functions. Healthy eating habits, including intake of fruits and vegetables, can modify gut microbiota. This study ai…
View article: Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review
Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review Open
Female infertility is a major public health concern and a global challenge. It is a disorder of the reproductive system, defined as the inability to achieve a clinical pregnancy. Nutrition and other environmental factors are found to impac…
View article: Increased Relative Abundance of Ruminoccocus Is Associated With Reduced Cardiovascular Risk in an Obese Population
Increased Relative Abundance of Ruminoccocus Is Associated With Reduced Cardiovascular Risk in an Obese Population Open
Background Obesity is a complex disease with underlying genetic, environmental, psychological, physiological, medical, and epigenetic factors. Obesity can cause various disorders, including cardiovascular diseases (CVDs), that are among th…
View article: Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement
Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement Open
Accurate risk prediction of acute graft versus host disease (aGvHD) is currently an unmet clinical need. This study sought to analyze whether three plasma proteins expressed in a largely skin- and gut-restricted manner would be affected by…
View article: 62nd Annual Conference of Indian Society of Hematology & Blood Transfusion (ISHBT)
62nd Annual Conference of Indian Society of Hematology & Blood Transfusion (ISHBT) Open
View article: Tube-Certified Trajectory Tracking for Nonlinear Systems With Robust Control Contraction Metrics
Tube-Certified Trajectory Tracking for Nonlinear Systems With Robust Control Contraction Metrics Open
This paper presents an approach towards guaranteed trajectory tracking for nonlinear control-affine systems subject to external disturbances based on robust control contraction metrics (CCM) that aims to minimize the $\mathcal L_\infty$ ga…
View article: Personalized Nutrition Approach in Pregnancy and Early Life to Tackle Childhood and Adult Non-Communicable Diseases
Personalized Nutrition Approach in Pregnancy and Early Life to Tackle Childhood and Adult Non-Communicable Diseases Open
The development of childhood and adult non-communicable diseases (NCD) is associated with environmental factors, starting from intrauterine life. A new theory finds the roots of epigenetic programming in parental gametogenesis, continuing …
View article: Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus
Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus Open
View article: Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar
Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar Open
In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level…
View article: The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease
The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease Open
Chronic kidney disease (CKD) is a globally common and important disease and there are evidence for a bidirectional relationship between microbiota and CKD. The aim of the study was to examine the influence of prebiotic - gum acacia (GA) on…
View article: Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data
Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data Open
Summary According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of A…
View article: Evaluation of Methods for the Extraction of Microbial DNA From Vaginal Swabs Used for Microbiome Studies
Evaluation of Methods for the Extraction of Microbial DNA From Vaginal Swabs Used for Microbiome Studies Open
Background: The composition of the microbiome in human body sites plays an important role in health. The vaginal environment is colonized by several species of bacteria that have a major influence on reproductive health. The advance…
View article: Intent-Aware Probabilistic Trajectory Estimation for Collision\n Prediction with Uncertainty Quantification
Intent-Aware Probabilistic Trajectory Estimation for Collision\n Prediction with Uncertainty Quantification Open
Collision prediction in a dynamic and unknown environment relies on knowledge\nof how the environment is changing. Many collision prediction methods rely on\ndeterministic knowledge of how obstacles are moving in the environment.\nHowever,…
View article: Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils
Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils Open
Steps involved in reductionist investigation approaches can be imitated using public transcriptome datasets as source of training material. In the present report trainees explored an apparent gap in biological knowledge for FAM129A (family…
View article: Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin
Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin Open