Explanipedia

Evaluating Renal Disease in Pediatric‐Onset Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome Open

K. Toor, Audrea Chen, David A. Cabral, Cherry Mammen, Else S. Bosman , et al. · 2024

Objective We aimed to study the disease course, outcomes, and predictors of outcome in pediatric‐onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) affecting the kidneys. Methods Patients eligible for this study h…

Comparing Rituximab and Cyclophosphamide in Induction Therapy for Childhood‐Onset Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis: An <span>ARChiVe</span> Registry Cohort Study Open

Samuel J Gagne, Vidya Sivaraman, Else S. Bosman, Brett Klamer, Kimberly Morishita , et al. · 2024

Objective Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are chronic life‐threatening vasculitides requiring substantial immunotherapy. Adult trials identified rituximab (RTX) as an alternative to cyclophosphamid…

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework Open

Kristen Hayward, Alexi Grom, Eyal Muscal, Peter A. Nigrović, Kelly Rouster‐Stevens , et al. · 2024

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework Open

Kristen Hayward, Alexi Grom, Eyal Muscal, Peter A. Nigrović, Kelly Rouster‐Stevens , et al. · 2023

Quality of life measures and physical activity in childhood systemic lupus erythematosus Open

Meghan Corrigan Nelson, Sinclair Gibson, D. Sofia Villacis-Nunez, Lai Hin Kimi Chan, Lori Ponder , et al. · 2022

Childhood systemic lupus erythematosus (cSLE) is a life-long disease with significant morbidity and mortality, and with associated significant impact on health-related quality of life (HRQOL). Previous literature supports that physical act…

Acute respiratory distress syndrome and COVID-19 in a child with systemic lupus erythematosus Open

Simone Sukhdeo, Emily Negroponte, Hariprem Rajasekhar, Sunanda Gaur, Daniel B. Horton , et al. · 2021

We report a case of COVID-19 in a pediatric patient with systemic lupus erythematosus (SLE), who presented with respiratory distress marked by increased work of breathing and low oxygen saturation. Lab tests confirmed COVID-19, and showed …

Epidermal Neurite Density in Skin Biopsies From Patients With Juvenile Fibromyalgia Open

Alexis Boneparth, Shan Chen, Daniel B. Horton, L. Nandini Moorthy, I.E. Farquhar , et al. · 2020

Objective Fibromyalgia (FM) is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with FM, a metaanalysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END)…

Comorbidities and Treatments in United States Youth with Chronic Musculoskeletal Pain Open

Matthew T. Taylor, Sabrina Gmuca, Alexis Boneparth, L. Nandini Moorthy, Daniel B. Horton · 2020

Introduction: Chronic musculoskeletal (MSK) pain has been associated with chronic illnesses and high rates of pain medication use, often in referral centers, European populations, or studies focused on single drug classes. We aimed to char…

Making Decisions About Stopping Medicines for Well‐Controlled Juvenile Idiopathic Arthritis: A Mixed‐Methods Study of Patients and Caregivers Open

Daniel B. Horton, Jomaira Salas, Aleksandra Wec, Melanie Kohlheim, Pooja Kapadia , et al. · 2019

Objective Improved treatments for juvenile idiopathic arthritis (JIA) have increased remission rates. We conducted this study to investigate how patients and caregivers make decisions about stopping medications when JIA is inactive. Method…

Clinical characteristics of children with membranous lupus nephritis: the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry Open

Alexis Boneparth, Scott E. Wenderfer, L. Nandini Moorthy, Suhas M. Radhakrishna, Anna Carmela P. Sagcal‐Gironella , et al. · 2016

Objective The objective of this article is to describe and compare clinical features, treatment, and renal outcomes of children with membranous lupus nephritis (MLN), through analysis of a national multicenter registry. Methods Patients wi…

Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting Open

Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony R. French, Phillip I. Tarr , et al. · 2016

Simple screening tool for assessing attention deficit in pediatric lupus Open

Farzana Nuruzzaman, Yekaterina Sherman, Barbara Ostfeld, Andrew Adams, Nancy Pan , et al. · 2015

Stratification of patients with autoinflammatory phenotypes by interferon (IFN) score suggests a new group of IFN mediated autoinflammatory diseases with overlapping clinical phenotypes Open

Adriana A. de Jesus, Z Deng, Stephen P.J. Brooks, Hyunsook Kim, Gina Montealegre , et al. · 2015

Complement Inhibition in the Treatment of SLE-Associated Thrombotic Thrombocytopenic Purpura Open

Alexis Boneparth, L. Nandini Moorthy, Lynne Weiss, Hariprem Rajasekhar, Susan Murphy , et al. · 2015

Thrombotic thrombocytopenic purpura (TTP) is a well-described complication of systemic lupus erythematosus (SLE).1 Historically, plasma exchange has been the mainstay of treatment for TTP as well as for other thrombotic microangiopathies.2…

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