Lakshmi Nagendra
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View article: Metformin use & asthma outcomes in patients with concurrent diabetes & bronchial asthma: A systematic review & meta-analysis
Metformin use & asthma outcomes in patients with concurrent diabetes & bronchial asthma: A systematic review & meta-analysis Open
Background & objectives Limited data exist on the effects of metformin on asthma outcomes in patients having type 2 diabetes (T2D) along with asthma. This meta-analysis seeks to determine whether metformin influences asthma outcomes in the…
View article: Safety and efficacy of efruxifermin in metabolic dysfunction-associated steatohepatitis: A systematic review
Safety and efficacy of efruxifermin in metabolic dysfunction-associated steatohepatitis: A systematic review Open
BACKGROUND Efruxifermin (EFX), a fibroblast growth factor 21 analogue, has demonstrated the potential to improve liver fat and markers of liver injury, fibrosis, and key metabolic biomarkers in individuals with metabolic dysfunction-associ…
View article: Prevalence of diabetes distress among people with type 2 diabetes in South Asia: A systematic review and meta-analysis.
Prevalence of diabetes distress among people with type 2 diabetes in South Asia: A systematic review and meta-analysis. Open
South Asians with T2D seem to experience a relatively high burden of DD, and the emotional burden is the most common form of DD in this area. Larger studies utilizing unique tools and involving a broader participant base from the region wo…
View article: Efficacy and Safety of Once-Weekly IcoSema in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis
Efficacy and Safety of Once-Weekly IcoSema in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis Open
View article: Safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with type 2 diabetes mellitus fasting during Ramadan: a systematic review and meta-analysis
Safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with type 2 diabetes mellitus fasting during Ramadan: a systematic review and meta-analysis Open
BACKGROUND Data on the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in individuals with type 2 diabetes mellitus (T2DM) during Ramadan fasting is limited. No meta-analysis has summarized the safety and effectiveness of GLP-1…
View article: Impacts of Ramadan Fasting on Metabolic and Hepatic Endpoints in Individuals With Metabolic Dysfunction‐Associated Fatty Liver Disease: A Systematic Review and Meta‐Analysis
Impacts of Ramadan Fasting on Metabolic and Hepatic Endpoints in Individuals With Metabolic Dysfunction‐Associated Fatty Liver Disease: A Systematic Review and Meta‐Analysis Open
Objective Previous studies examining the impact of Ramadan fasting on patients with metabolic dysfunction‐associated fatty liver disease (MAFLD) have yielded mixed results. Therefore, assessing the health benefits of such fasting in patien…
View article: Safety of esaxerenone (CS-3150) and its impacts on blood pressure and renal function: A systematic review and meta-analysis
Safety of esaxerenone (CS-3150) and its impacts on blood pressure and renal function: A systematic review and meta-analysis Open
Background: The safety and efficacy of esaxerenone (ESAX), a novel nonsteroidal mineralocorticoid receptor antagonist, remain insufficiently explored in systematic reviews and meta-analyses (SR/MA). This SR/MA aimed to investigate the safe…
View article: Thrice-Weekly Insulin Degludec Versus Once-Daily Insulin Glargine in Insulin-Naïve Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Thrice-Weekly Insulin Degludec Versus Once-Daily Insulin Glargine in Insulin-Naïve Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
Aims/Background Data from randomized controlled trials (RCTs) comparing the efficacy and safety of thrice-weekly insulin degludec (IDeg 3TW) versus once-daily insulin glargine (IGlar OD) in patients with type 2 diabetes mellitus (T2DM) are…
View article: Efficacy and Safety of Twincretin Survodutide, a Dual Glucagon-Like Peptide-1 and Glucagon Receptor Agonist as an Anti-Obesity and Anti-Diabetes Medication: A Systematic Review and Meta-Analysis
Efficacy and Safety of Twincretin Survodutide, a Dual Glucagon-Like Peptide-1 and Glucagon Receptor Agonist as an Anti-Obesity and Anti-Diabetes Medication: A Systematic Review and Meta-Analysis Open
Survodutide is a twincretin having dual glucagon-like peptide-1 and glucagon receptor agonist activity, conceptually based on endogenous peptide oxyntomodulin. This systematic review and meta-analysis (SRM) holistically analyzed the body w…
View article: Obesonomics
Obesonomics Open
Economic and commercial determinants of health, as wellas health- related determinants of economy, are graduallybeing understood by researchers and public healthspecialists. One condition which is influenced by economicfactors, and which a…
View article: Assessment of Bone Health in Type 2 Diabetes Mellitus
Assessment of Bone Health in Type 2 Diabetes Mellitus Open
Type 2 diabetes mellitus (T2DM) affects bone health, increasing the risk of fracture despite normal or elevated bone mineral density (BMD). This paradox is attributed to impaired bone quality, microarchitectural defects and advanced glycat…
View article: SOCIAL MEDIA AND GERIATRIC HEALTH: PROMISES AND PITFALLS
SOCIAL MEDIA AND GERIATRIC HEALTH: PROMISES AND PITFALLS Open
SOCIAL MEDIA AND GERIATRIC HEALTH: PROMISES AND PITFALLS
View article: Challenges in Type 1 Diabetes Management in India Compared to Singapore
Challenges in Type 1 Diabetes Management in India Compared to Singapore Open
View article: WCN25-2795 BONE MINERAL DENSITY PROFILE IN CHILDREN RECEIVING CORTICOSTEROIDS FOR RENAL INDICATIONS FOR MORE THAN TWELVE WEEKS
WCN25-2795 BONE MINERAL DENSITY PROFILE IN CHILDREN RECEIVING CORTICOSTEROIDS FOR RENAL INDICATIONS FOR MORE THAN TWELVE WEEKS Open
View article: Tirzepatide and Cancer Risk in Individuals with and without Diabetes: A Systematic Review and Meta-Analysis
Tirzepatide and Cancer Risk in Individuals with and without Diabetes: A Systematic Review and Meta-Analysis Open
Background: Data on the carcinogenic potential of tirzepatide from randomized controlled trials (RCTs) are limited. Furthermore, no meta-analysis has included all relevant RCTs to assess the cancer risk associated with tirzepatide.Methods:…
View article: Role of Sodium–Glucose Cotransporter-2 Inhibitors in Managing Polycystic Ovary Syndrome: A Systematic Review
Role of Sodium–Glucose Cotransporter-2 Inhibitors in Managing Polycystic Ovary Syndrome: A Systematic Review Open
SGLT2i, when used as monotherapy or combined with metformin or GLP1RA, are a promising therapy for improving metabolic and hormonal parameters in PCOS.
View article: Sequential administration of abbreviated (up to one month) dual antiplatelet therapy and Ticagrelor monotherapy versus standard dual antiplatelet therapy after percutaneous coronary intervention: A meta-analysis
Sequential administration of abbreviated (up to one month) dual antiplatelet therapy and Ticagrelor monotherapy versus standard dual antiplatelet therapy after percutaneous coronary intervention: A meta-analysis Open
OBJECTIVE: Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12 inhibitor, has been crucial for reducing ischemic events during the critical period following percutaneous coronary intervention PCI. The optimal duration of DA…
View article: Efficacy and Safety of Early Initiation of Sodium–Glucose Co-transporter-2 Inhibitors Following Acute Myocardial Infarction: A Systematic Review and Meta-analysis
Efficacy and Safety of Early Initiation of Sodium–Glucose Co-transporter-2 Inhibitors Following Acute Myocardial Infarction: A Systematic Review and Meta-analysis Open
Early initiation of SGLT2i in acute MI is safe, well tolerated and associated with a reduction in HHF.
View article: Human-AI Collaboration in Academic Writing: A Narrative Review and the Scholarly HI-AI Loop Framework for Ethical Knowledge Production
Human-AI Collaboration in Academic Writing: A Narrative Review and the Scholarly HI-AI Loop Framework for Ethical Knowledge Production Open
View article: Efficacy and Safety of Glucagon Like Peptide-1 Receptor Agonism Based Therapies in Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis
Efficacy and Safety of Glucagon Like Peptide-1 Receptor Agonism Based Therapies in Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis Open
Introduction: The exponential increase in obesity is responsible for the increased prevalence of obstructive sleep apnoea (OSA). Weight loss is critical to improvement in OSA. Glucagon-like peptide-1 receptor (GLP1R) agonism-based therapie…
View article: Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis
Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis Open
BACKGROUND Type 2 diabetes (T2D), as well as obesity, are risk factors for chronic kidney disease (CKD) and end-stage renal disease. The renal impacts of glucose-lowering and weight-lowering drugs and their potential benefits in preventing…
View article: Cost-effectiveness of FRAX®-based intervention thresholds for management of osteoporosis in Indian women: a Markov microsimulation model analysis
Cost-effectiveness of FRAX®-based intervention thresholds for management of osteoporosis in Indian women: a Markov microsimulation model analysis Open
View article: Pancreatic Safety of Tirzepatide and Its Effects on Islet Cell Function: A Systematic Review and Meta‐Analysis
Pancreatic Safety of Tirzepatide and Its Effects on Islet Cell Function: A Systematic Review and Meta‐Analysis Open
Background Endogenous glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) regulate islet cell function. GLP‐1 receptor agonists (GLP‐1RAs) have been associated with an elevated risk of acute pancreatitis.…
View article: Role of Obeticholic Acid, a Farnesoid X Receptor Agonist, in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Role of Obeticholic Acid, a Farnesoid X Receptor Agonist, in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis Open
Background. Obeticholic acid (OCA) has emerged as a promising drug in the management of nonalcoholic fatty liver disease (NAFLD). This meta-analysis aimed to analyse the therapeutic effect of OCA on NAFLD. Methods. Randomized…
View article: Efficacy and Safety of Cagrilintide Alone and in Combination with Semaglutide (Cagrisema) as Anti-Obesity Medications: A Systematic Review and Meta-Analysis
Efficacy and Safety of Cagrilintide Alone and in Combination with Semaglutide (Cagrisema) as Anti-Obesity Medications: A Systematic Review and Meta-Analysis Open
No meta-analysis has analysed role of cagrilintide as weight-loss medication in obese individuals. Electronic databases were searched for RCTs involving obese individuals receiving cagrilintide or cagrilintide-2.4 mg with semaglutide-2.4 m…
View article: Role of Growth Hormone Therapy in Metabolic-Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis
Role of Growth Hormone Therapy in Metabolic-Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis Open
Multiple observation studies and meta-analysis have linked growth hormone (GH) deficiency with metabolic-dysfunction-associated steatotic liver disease (MASLD). No meta-analysis has analysed the efficacy and safety of GH therapy on differe…
View article: Role of flibanserin in managing hypoactive sexual desire disorder in women: A systematic review and meta-analysis
Role of flibanserin in managing hypoactive sexual desire disorder in women: A systematic review and meta-analysis Open
Background: Flibanserin, approved for the treatment of hypoactive sexual desire disorder (HSDD) in females, has demonstrated diverse therapeutic and adverse effect (AE) prospects in the extant randomized controlled trials (RCTs). This meta…
View article: Efficacy and Safety of Osilodrostat in Managing Cushing’s Syndrome: A Systematic Review and Meta-Analysis
Efficacy and Safety of Osilodrostat in Managing Cushing’s Syndrome: A Systematic Review and Meta-Analysis Open
No meta-analysis has holistically analysed and summarized the efficacy and safety of osilodrostat, a novel dual 11β-hydroxylase (cytochrome P450 family 11 subfamily B member 1 [CYP11B1]) and 18-hydroxylase (aldosterone synthase, CYP11B2) i…
View article: Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies
Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies Open
Global warming and endocrine disorders are intertwined issues posing significant challenges. Greenhouse gases emanating from human activities drive global warming, leading to temperature rise and altered weather patterns. South Asia has ex…
View article: Transient Neonatal Hypocortisolism in Neonates with Hypoglycemia – Coexistence or Cause?
Transient Neonatal Hypocortisolism in Neonates with Hypoglycemia – Coexistence or Cause? Open
Introduction: Infants born preterm, with low birth weight (LBW), or with perinatal stress are at high risk for neonatal hypoglycemia. Low cortisol levels have also been demonstrated in this group of neonates, which is often transient. We r…