Lakshmi Ravindranath
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View article: AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer Open
Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300, which are histone acetyltransferases, were identified as critical m…
View article: Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men Open
Growing evidence indicates the involvement of a genetic component in prostate cancer (CaP) susceptibility and clinical severity. Studies have reported the role of germline mutations and single nucleotide polymorphisms (SNPs) of TP53 as pos…
View article: Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men Open
Growing evidence indicates the involvement of a genetic component for CaP susceptibility and clinical severity. Somatic mutations of TP53 have been associated with 50% of diverse human cancers. Studies have also reported the role of germ l…
View article: Table S1, S2 from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Table S1, S2 from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells Open
ERG binding sites on NOTCH1 and NOTCH2 promoters and primer sequences used to amplify these locations.
View article: Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells Open
The oncogenic activation of the ETS-related gene (ERG) due to gene fusions is present in over half of prostate cancers in Western countries. Because of its high incidence and oncogenic role, ERG and components of ERG network have em…
View article: Table S1, S2 from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Table S1, S2 from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells Open
ERG binding sites on NOTCH1 and NOTCH2 promoters and primer sequences used to amplify these locations.
View article: Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells
Data from Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells Open
The oncogenic activation of the ETS-related gene (ERG) due to gene fusions is present in over half of prostate cancers in Western countries. Because of its high incidence and oncogenic role, ERG and components of ERG network have em…
View article: Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy Open
Purpose: A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles …
View article: Supplementary Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
Supplementary Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer Open
Supplementary Data from Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer
View article: Supplementary Figures S6- S12 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Figures S6- S12 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S6. Evaluation of combined effect of ERGi-USU and AR inhibitors on CaP cell growth, S7. Selective inhibition of ERG positive cancer cells by ERGi-USU in mouse xenograft model, S8. Assessment of effect of RIOK knock down in ERG positive VCa…
View article: Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S1. Comparison and confirmation of ERGi-USU effect on ERG protein, cell growth and gene expression, S2. Antibody based Screening and identification of small molecule inhibitors of the ERG oncoprotein expression, S3. Evaluation of dose-depe…
View article: Supplementary Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
Supplementary Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer Open
Supplementary Data from Delineation of TMPRSS2-ERG Splice Variants in Prostate Cancer
View article: Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer Open
Purpose: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions …
View article: Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S1. PCR primer list for ERG, S2. IC50 values of Inhibition of ERG protein and cell growth of ERGi-USU on established cell panel
View article: Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer Open
Purpose: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions …
View article: Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
Oncogenic activation of the ETS-related gene (ERG) by recurrent gene fusions (predominantly TMPRSS2–ERG) is one of the most validated and prevalent genomic alterations present in early stages of prostate cancer. In this study, we sc…
View article: Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
Reagents. Antibodies for Immunoblot, methods for qPCR, Tunnel assay and Determination of equilibrium dissociation constant (Kd) of RIOK proteins and Additional references supporting the ERGi-USU manuscript
View article: Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S1. PCR primer list for ERG, S2. IC50 values of Inhibition of ERG protein and cell growth of ERGi-USU on established cell panel
View article: Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival Open
Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene PSA/HK3 mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
View article: Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
Oncogenic activation of the ETS-related gene (ERG) by recurrent gene fusions (predominantly TMPRSS2–ERG) is one of the most validated and prevalent genomic alterations present in early stages of prostate cancer. In this study, we sc…
View article: Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival Open
Supplementary Tables S1-S4 from Higher Expression of the Androgen-Regulated Gene PSA/HK3 mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
View article: Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy Open
Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
View article: Data from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
Data from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival Open
Purpose: Alterations of the androgen receptor (AR)-mediated signaling through numerous mechanisms are increasingly recognized in prostate cancer (CaP) progression. We hypothesized that the assessment of well-defined AR transcription…
View article: Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy Open
Purpose: A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles …
View article: Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S1. Comparison and confirmation of ERGi-USU effect on ERG protein, cell growth and gene expression, S2. Antibody based Screening and identification of small molecule inhibitors of the ERG oncoprotein expression, S3. Evaluation of dose-depe…
View article: Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
Reagents. Antibodies for Immunoblot, methods for qPCR, Tunnel assay and Determination of equilibrium dissociation constant (Kd) of RIOK proteins and Additional references supporting the ERGi-USU manuscript
View article: Data from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
Data from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival Open
Purpose: Alterations of the androgen receptor (AR)-mediated signaling through numerous mechanisms are increasingly recognized in prostate cancer (CaP) progression. We hypothesized that the assessment of well-defined AR transcription…
View article: Supplementary Figures S6- S12 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Supplementary Figures S6- S12 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth Open
S6. Evaluation of combined effect of ERGi-USU and AR inhibitors on CaP cell growth, S7. Selective inhibition of ERG positive cancer cells by ERGi-USU in mouse xenograft model, S8. Assessment of effect of RIOK knock down in ERG positive VCa…
View article: Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy Open
Supplementary Tables 1-5, Supplementary Figures 1-4 from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
View article: Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes Open