Lamia Heikal
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View article: Antibacterial synergistic behaviour of phytosynthesized magnesium oxide nanoparticles with clove essential oil
Antibacterial synergistic behaviour of phytosynthesized magnesium oxide nanoparticles with clove essential oil Open
While researchers continue to search for new antibacterial agents, combination therapy as well as nanotechnology-based treatments allure as promising approaches to tackle antibiotic resistance. The present study aimed to phytosynthesize ma…
View article: Microneedle loaded with luteolin-colostrum-derived exosomes: a dropless approach for treatment of glaucoma
Microneedle loaded with luteolin-colostrum-derived exosomes: a dropless approach for treatment of glaucoma Open
Glaucoma, a leading cause of irreversible blindness, is marked by elevated intraocular pressure (IOP) and retinal ganglion cell death. Traditional IOP-lowering eye drops often fail to penetrate the ocular barrier, leading to suboptimal out…
View article: Bilosomal delivery of thymol-glycyrrhetinic acid: a multifaceted strategy to combat multidrug-resistant wound infections
Bilosomal delivery of thymol-glycyrrhetinic acid: a multifaceted strategy to combat multidrug-resistant wound infections Open
Purpose Antimicrobial-resistant bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA), have a long-term negative impact on wound healing. To combat the rising problem of bacterial resistance to conventional ant…
View article: The future of cardiac repair: a review on cell-free nanotherapies for regenerative myocardial infarction
The future of cardiac repair: a review on cell-free nanotherapies for regenerative myocardial infarction Open
Cardiovascular diseases as myocardial infarction (MI) represent a major cause for morbidity and mortality worldwide. Even though, patients who survive MI are susceptible to high risk of heart failure. This is mainly attributed to the major…
View article: EFFECT OF TOPICAL MELATONIN LOADED GELATIN SPONGE ON PALATAL WOUND HEALING (RANDOMIZED CONTROLLED CLINICAL TRIAL)
EFFECT OF TOPICAL MELATONIN LOADED GELATIN SPONGE ON PALATAL WOUND HEALING (RANDOMIZED CONTROLLED CLINICAL TRIAL) Open
For many muco-gingival deformities, autogenous soft tissue grafts are the gold standard treatment. Epithelialized graft harvesting technique is one of the most efficient. Yet, it leaves an open palatal wound that is only healed by secondar…
View article: Efficacy of a Novel Melatonin-Loaded Gelatin Sponge in Palatal Wound Healing
Efficacy of a Novel Melatonin-Loaded Gelatin Sponge in Palatal Wound Healing Open
View article: Efficacy of topical Omega-3 emulgel in preventing radiation-induced oral mucositis: A randomized clinical trial
Efficacy of topical Omega-3 emulgel in preventing radiation-induced oral mucositis: A randomized clinical trial Open
Introduction: One of the most common debilitating side effects that head and neck cancer patients suffer from during radiation therapy is oral mucositis. This leads to severe oral mucosal inflammation and ulceration that hinder the patient…
View article: Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer Open
Skin cancer is a widespread type of cancer representing 30% of all cancer types worldwide. Resveratrol (RSV) is an anticancer drug used for skin cancer treatment. Several limitations of RSV such as poor aqueous solubility, first-pass metab…
View article: Effect of Bone Marrow Mesenchymal Stem Cells derived Exosomes loaded in Collagen Hydrogel on Bone Regeneration in male Rat Calvarial Critical-Size Bone Defect
Effect of Bone Marrow Mesenchymal Stem Cells derived Exosomes loaded in Collagen Hydrogel on Bone Regeneration in male Rat Calvarial Critical-Size Bone Defect Open
INTRODUCTION:Expanded bone damage in defects of critical size demands interventions for the complete regeneration.However, limitations of the previous strategies include reduced availability of autograft donors.The therapeutic efficacy of …
View article: Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial
Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial Open
Background Surgical gingivectomy can be considered the gold standard treatment for gingival enlargement. The healing of wound site after gingivectomy occurs slowly by secondary intention. To accelerate the wound healing process, several st…
View article: Omega-3 nanoemulgel in prevention of radiation-induced oral mucositis and its associated effect on microbiome: a randomized clinical trial
Omega-3 nanoemulgel in prevention of radiation-induced oral mucositis and its associated effect on microbiome: a randomized clinical trial Open
Background Oral mucositis (OM) is recognized as one of the most frequent debilitating sequelae encountered by head and neck cancer (HNC) patients treated by radiotherapy. This results in severe mucosal tissue inflammation and oral ulcerati…
View article: Impact of vaginal submucosal platelet-rich plasma combined with non-cross-linked hyaluronic acid injections on dyspareunia and sexual satisfaction in a Hodgkin lymphoma cancer survivor: a case report
Impact of vaginal submucosal platelet-rich plasma combined with non-cross-linked hyaluronic acid injections on dyspareunia and sexual satisfaction in a Hodgkin lymphoma cancer survivor: a case report Open
Vaginal atrophy is a commonly encountered problem among young cancer survivors. Patients suffer from vaginal dryness, irritation, and dyspareunia secondary to oestrogen deficiency. Oestrogenbased hormone replacement therapy is effective, b…
View article: Repurposing 1,2,4-oxadiazoles as SARS-CoV-2 PLpro inhibitors and investigation of their possible viral entry blockade potential
Repurposing 1,2,4-oxadiazoles as SARS-CoV-2 PLpro inhibitors and investigation of their possible viral entry blockade potential Open
View article: Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis Open
Liver fibrosis is a global life-threatening disorder with no approved treatment. It leads to serious hepatic complications when progressive, such as cirrhosis and carcinoma. Luteolin (LUT) is a plant flavonoid possessing a promising therap…
View article: Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach Open
Albeit its established efficacy as an anti-hyperlipidemic agent, pitavastatin (PIT) has been shown to have other various therapeutic effects. One of these effects is the anti-cancer activity against hepatocellular carcinoma (HCC). This eff…
View article: POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY
POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY Open
Resveratrol-loaded multilamellar liposomes have a protective role on doxorubicin-induced cardiotoxicity in adult male albino rats proved by histological studies.The present study was conducted over 5 successive weeks on 30 adult male albin…
View article: The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial
The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial Open
Background: The healing of an extraction socket leads to alveolar ridge resorption that can hinder future implant placement and further rehabilitation with special concerns in diabetes mellitus. Coenzyme Q10 (CoQ10) has been developed as a…
View article: Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal
Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal Open
Flurbiprofen (FLUR) is a potent non-steroidal anti-inflammatory drug used for the management of arthritis. Unfortunately, its therapeutic effect is limited by its rapid clearance from the joints following intra-articular injection. To impr…
View article: Correction to: Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo
Correction to: Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo Open
View article: Correction to: Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Correction to: Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
View article: 3D Bioprinting of Novel Biocompatible Scaffolds for Endothelial Cell Repair
3D Bioprinting of Novel Biocompatible Scaffolds for Endothelial Cell Repair Open
The aim of this study was to develop and evaluate an optimized 3D bioprinting technology in order to fabricate novel scaffolds for the application of endothelial cell repair. Various biocompatible and biodegradable macroporous scaffolds (D…
View article: Inflammation-induced reactive nitrogen species cause proteasomal degradation of dimeric peroxiredoxin-1 in a mouse macrophage cell line
Inflammation-induced reactive nitrogen species cause proteasomal degradation of dimeric peroxiredoxin-1 in a mouse macrophage cell line Open
Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7 mous…
View article: Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
View article: l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex
l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex Open
Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function. NO is extremely labile and has been challenging to develop as a therapeutic agent. However, NO bioavailability could be enhanced by pharmacological…
View article: Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo
Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo Open
View article: Additional file 3: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Additional file 3: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
Genes increased by LIF and unchanged or decreased by differentiation or EPO at 1 h. The genes increased more than 1.5-fold (log2 FC ≥ 0.58), BH adj. P value
View article: Additional file 4: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Additional file 4: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
Genes increased by LIF and unchanged or decreased by differentiation or EPO at 20 h. The genes increased more than 1.5-fold (log2 FC ≥ 0.58), BH adj. P value
View article: Additional file 1: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Additional file 1: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
Genes increased by EPO in differentiating cells at 1 h. Genes changed more than 1.5-fold (absolute log2 FC > 0.58), BH adj. P value
View article: Additional file 2: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes
Additional file 2: of Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes Open
Genes increased by LIF and by differentiation at 1 h. These genes have been identified by comparing EPO + LIF vs EPO and differentiating (dif) vs undifferentiated (undif) cells, setting a threshold of log2 FC ≥ 0.58 and BH adj. P value
View article: Erythropoietin Increases Myelination in Oligodendrocytes: Gene Expression Profiling Reveals Early Induction of Genes Involved in Lipid Transport and Metabolism
Erythropoietin Increases Myelination in Oligodendrocytes: Gene Expression Profiling Reveals Early Induction of Genes Involved in Lipid Transport and Metabolism Open
Several studies have shown that erythropoietin (EPO) has neuroprotective or neuroreparative actions on diseases of the nervous system and that improves oligodendrocyte (OL) differentiation and myelination in vivo and in vitro…