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View article: Double peroxidase and histone acetyltransferase AgTip60 maintain innate immune memory in primed mosquitoes
Double peroxidase and histone acetyltransferase AgTip60 maintain innate immune memory in primed mosquitoes Open
Significance A previous Plasmodium infection enhances the mosquito immune response to subsequent infections. Priming is mediated by a hemocyte differentiation factor (HDF) consisting of lipoxin A 4 (LXA 4 ) bound to Evokin, a lipid carrier…
View article: Design of Dissolvable Microneedles for Delivery of a Pfs47-Based Malaria Transmission-Blocking Vaccine
Design of Dissolvable Microneedles for Delivery of a Pfs47-Based Malaria Transmission-Blocking Vaccine Open
The development of effective malaria vaccines remains a global health priority. In addition to an effective vaccine, there is urgent demand for effective delivery technologies that can be easily deployed. The need for effective vaccine del…
View article: In vivo Characterization of Plasmodium berghei P47 (Pbs47) as a Malaria Transmission-Blocking Vaccine Target
In vivo Characterization of Plasmodium berghei P47 (Pbs47) as a Malaria Transmission-Blocking Vaccine Target Open
An effective vaccine to reduce malaria transmission is central to control and ultimately achieve disease eradication. Recently, we demonstrated that antibodies targeting the Plasmodium falciparum surface protein P47 (Pfs47) reduce p…
View article: <i>Plasmodium falciparum</i> evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor
<i>Plasmodium falciparum</i> evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor Open
Significance The surface protein Pfs47 makes Plasmodium falciparum parasites “undetectable” to the mosquito immune system. We proposed the “lock and key” model in which a parasite expressing a compatible Pfs47 haplotype “the key,” is able …
View article: Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases
Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases Open
Despite the success of vaccines in preventing many infectious diseases, effective vaccines against pathogens with ongoing challenges - such as HIV, malaria, and tuberculosis - remain unavailable. The emergence of new pathogen variants, the…
View article: DEVELOPMENT AND OPTIMIZATION OF A P47-BASED PLASMODIUM VACCINE TO BLOCK MALARIA TRANSMISSION
DEVELOPMENT AND OPTIMIZATION OF A P47-BASED PLASMODIUM VACCINE TO BLOCK MALARIA TRANSMISSION Open
Malaria is an infectious disease caused by Plasmodium parasites that are transmitted to hosts by infected Anopheles mosquitoes. Over the last two decades, the widespread deployment of effective interventions, such as drugs and insecticides…
View article: Engineering a Virus-Like Particle as an Antigenic Platform for a Pfs47-Targeted Malaria Transmission-Blocking Vaccine
Engineering a Virus-Like Particle as an Antigenic Platform for a Pfs47-Targeted Malaria Transmission-Blocking Vaccine Open
We recently characterized Pfs47, a protein expressed on the surface of sexual stages and ookinetes of Plasmodium falciparum , as a malaria transmission-blocking vaccine (TBV) target. Mice immunization induced antibodies that conferred stro…
View article: Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission
Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission Open