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View article: Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes
Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes Open
Neural representations arise from the spatiotemporally structured activity of neuron populations, inherently residing in high-dimensional spaces. Writing specific information into the central nervous system requires precisely manipulating …
View article: Temporal coding carries more stable cortical visual representations than firing rate over time
Temporal coding carries more stable cortical visual representations than firing rate over time Open
The brain’s ability to stably represent recurring visual scenes is crucial for behavior. Previous studies have used slow dynamic (1-5 seconds) rate code measurements to study visual tuning, revealing varying degrees of gradual activity cha…
View article: Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts
Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts Open
Microinfarcts, the “invisible lesions”, are prevalent in aged and injured brains and associated with cognitive impairments, yet their neurophysiological impact remains largely unknown. Using a multimodal chronic neural platform that combin…
View article: Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior
Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior Open
Implantable electrode arrays are powerful tools for directly interrogating neural circuitry in the brain, but implementing this technology in the spinal cord in behaving animals has been challenging due to the spinal cord's significant mot…
View article: Clinical outcomes of peripheral nerve interfaces for rehabilitation in paralysis and amputation: a literature review
Clinical outcomes of peripheral nerve interfaces for rehabilitation in paralysis and amputation: a literature review Open
Peripheral nerve interfaces (PNIs) are electrical systems designed to integrate with peripheral nerves in patients, such as following central nervous system (CNS) injuries to augment or replace CNS control and restore function. We review t…
View article: Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity
Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity Open
Penetrating neural electrodes provide a powerful approach to decipher brain circuitry by allowing for time-resolved electrical detections of individual action potentials. This unique capability has contributed tremendously to basic and tra…
View article: Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes
Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes Open
Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation are often compromised by adverse tissue r…
View article: Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes
Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes Open
Summary Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation is often compromised by the adver…
View article: Longitudinal neural and vascular recovery following ultraflexible neural electrode implantation in aged mice
Longitudinal neural and vascular recovery following ultraflexible neural electrode implantation in aged mice Open
Flexible neural electrodes improve the recording longevity and quality of individual neurons by promoting tissue-electrode integration. However, the intracortical implantation of flexible electrodes inevitably induces tissue damage. Unders…
View article: A Study on Conceptual Metaphors in the Report on the Work of the Government (2020)
A Study on Conceptual Metaphors in the Report on the Work of the Government (2020) Open
The Report on the work of government (2020) is an annually political discourse, which provides a consistent topic to linguistic research. And conceptual metaphor provided by George Lakoff, is an important part of cognitive linguistics and …
View article: Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording
Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording Open
Implanted electrodes provide one of the most important neurotechniques for fundamental and translational neurosciences by permitting time-resolved electrical detection of individual neurons in vivo. However, conventional rigid electrodes t…
View article: Dynamics of isoflurane-induced vasodilation and blood flow of cerebral vasculature revealed by multi-exposure speckle imaging
Dynamics of isoflurane-induced vasodilation and blood flow of cerebral vasculature revealed by multi-exposure speckle imaging Open
Background Anesthetized animal models are used extensively during neurophysiological and behavioral studies despite systemic effects from anesthesia that undermine both accurate interpretation and translation to awake human physiology. The…
View article: Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes
Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes Open
Ministrokes induce long-lasting neurovascular dissociations.
View article: Clustering with Fast, Automated and Reproducible assessment applied to longitudinal neural tracking
Clustering with Fast, Automated and Reproducible assessment applied to longitudinal neural tracking Open
Across many areas, from neural tracking to database entity resolution, manual assessment of clusters by human experts presents a bottleneck in rapid development of scalable and specialized clustering methods. To solve this problem we devel…
View article: Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes
Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes Open
Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal,…
View article: Nanofabricated Ultraflexible Electrode Arrays for High‐Density Intracortical Recording
Nanofabricated Ultraflexible Electrode Arrays for High‐Density Intracortical Recording Open
Understanding brain functions at the circuit level requires time‐resolved simultaneous measurement of a large number of densely distributed neurons, which remains a great challenge for current neural technologies. In particular, penetratin…
View article: Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes
Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes Open
Brain function can be best studied by simultaneous measurements and modulation of the multifaceted signaling at the cellular scale. Extensive efforts have been made to develop multifunctional neural probes, typically involving highly speci…
View article: A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery
A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery Open
The microfluidic meshwork elicited minimal fibrosis and capsule formation after 3-months implantation in a rabbit model. This provides promising evidence to aid in future development of a new glaucoma drainage implant that will elicit mini…
View article: Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration
Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration Open
Subcellular-sized, ultraflexible electrodes form seamless integration with the living brain and afford chronically reliable recording.
View article: Uncovering edge states and electrical inhomogeneity in MoS <sub>2</sub> field-effect transistors
Uncovering edge states and electrical inhomogeneity in MoS <sub>2</sub> field-effect transistors Open
Significance The performances of devices based on transition metal dichalcogenides (TMDs) are far from their intrinsic limits, presumably due to various disorders in these 2D crystals. To date, little is known about the magnitude and chara…