Guang Ning
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View article: Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity
Phenotyping obesity through a two-dimensional tree structure reveals cardiometabolic heterogeneity Open
Obesity, a major public health challenge, is characterized by substantial phenotypic heterogeneity. Here, we employ the discriminative dimensionality reduction tree (DDRTree) method to routine clinical data from 18,733 Chinese individuals …
View article: Heterogeneity In Phenotype And Early Metabolic Response To Lifestyle Interventions In Type 2 Diabetes In China Utilizing A Tree-like Representation
Heterogeneity In Phenotype And Early Metabolic Response To Lifestyle Interventions In Type 2 Diabetes In China Utilizing A Tree-like Representation Open
Deciphering the heterogeneity of type 2 diabetes in prognosis and treatment effect is essential. We aimed to use a novel dimensionality reduction approach to describe type 2 diabetes phenotype continuum and to visualize the difference in l…
View article: Heterogeneity In Phenotype And Early Metabolic Response To Lifestyle Interventions In Type 2 Diabetes In China Utilizing A Tree-like Representation
Heterogeneity In Phenotype And Early Metabolic Response To Lifestyle Interventions In Type 2 Diabetes In China Utilizing A Tree-like Representation Open
Deciphering the heterogeneity of type 2 diabetes in prognosis and treatment effect is essential. We aimed to use a novel dimensionality reduction approach to describe type 2 diabetes phenotype continuum and to visualize the difference in l…
View article: Heterogeneity of diabetes and disease progression with a tree-like representation: findings from the China Cardiometabolic Disease and Cancer Cohort (4C) study
Heterogeneity of diabetes and disease progression with a tree-like representation: findings from the China Cardiometabolic Disease and Cancer Cohort (4C) study Open
These findings characterise the heterogeneity of diabetes phenotypes and complication risks in the Chinese population, suggesting potential implications for personalised diabetes care. Given the observed phenotypic differences, management …
View article: A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium
A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium Open
Adipose tissue serves as a crucial energy storage and metabolic organ in the human body. With the surging of elderly population in China comes significant challenges in preventing and managing age-associated diseases, while adipose tissue …
View article: Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease
Analysis of exhaled nitric oxide and its influencing factors in patients with chronic obstructive pulmonary disease Open
Objectives To compare exhaled nitric oxide (eNO) levels between patients with chronic obstructive pulmonary disease (COPD) and healthy controls, and to investigate factors influencing eNO measurements. Methods The study included 115 patien…
View article: Elucidating the heterogeneity of prediabetes through subphenotyping with a two-dimensional tree structure
Elucidating the heterogeneity of prediabetes through subphenotyping with a two-dimensional tree structure Open
Prediabetes, an intermediate stage of developing diabetes, exhibits considerable phenotypic heterogeneity. Here, we apply the Discriminative Dimensionality Reduction Tree (DDRTree) algorithm to explore prediabetes heterogeneity in 55,777 p…
View article: Multivariate genome-wide analyses of insulin resistance phenotypes unravel novel loci and therapeutic targets for cardiometabolic health and longevity
Multivariate genome-wide analyses of insulin resistance phenotypes unravel novel loci and therapeutic targets for cardiometabolic health and longevity Open
Insulin resistance (IR) is a key risk factor for cardiometabolic diseases and premature death with unmet therapeutic needs. The limited identification of IR-associated loci hinders understanding its causal role in cardiometabolic health an…
View article: Management Guidelines for Diabetic Patients With Hypertension
Management Guidelines for Diabetic Patients With Hypertension Open
Hypertension is one of the most common comorbidities associated with diabetes. The standardized diagnosis and treatment of hypertension in diabetic patients, along with achieving blood pressure targets, is of great significance for reducin…
View article: Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study
Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study Open
Background To determine the associations between sleep phenotypes and the risks of specific obesity types and weight gain in patients with type 2 diabetes (T2D), especially in different genetic risk groups. Materials and Methods We conduct…
View article: Identifying <scp>PDAP1</scp> as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study
Identifying <span>PDAP1</span> as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study Open
Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian rando…
View article: Retraction notice to "Predictive modeling the probability of suffering from metabolic syndrome using machine learning: A population-based study" [Heliyon 8 (2022) e12343]
Retraction notice to "Predictive modeling the probability of suffering from metabolic syndrome using machine learning: A population-based study" [Heliyon 8 (2022) e12343] Open
[This retracts the article DOI: 10.1016/j.heliyon.2022.e12343.].
View article: Disentangling Organ‐Specific Roles of Farnesoid X Receptor in Bile Acid and Glucolipid Metabolism
Disentangling Organ‐Specific Roles of Farnesoid X Receptor in Bile Acid and Glucolipid Metabolism Open
Background and Aims The farnesoid X receptor (FXR) is an attractive pharmaceutical target for metabolic dysfunction‐associated steatotic liver disease (MASLD). However, its tissue‐specific roles in energy metabolism remain controversial, h…
View article: Association of body roundness index with cardiovascular disease and all‐cause mortality among Chinese adults
Association of body roundness index with cardiovascular disease and all‐cause mortality among Chinese adults Open
Aims To determine the impact of body roundness index (BRI) on the 10‐year risk of cardiovascular disease (CVD) and all‐cause mortality in Chinese adults. Materials and Methods We utilized data from a nationwide prospective cohort of 165 78…
View article: Compound heterozygous PROC mutations cause lipedema in humans
Compound heterozygous PROC mutations cause lipedema in humans Open
Lipedema is a hereditary disorder characterized by excessive accumulation of subcutaneous adipose tissue in the limbs. The genetic causes and mechanisms underlying abnormal adipocyte expansion in lipedema, however, remain unknown. Here, we…
View article: WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals
WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals Open
Mitochondrial rRNAs play important roles in regulating mtDNA-encoded gene expression and energy metabolism subsequently. However, the proteins that regulate mitochondrial 16S rRNA processing remain poorly understood. Herein, we generated a…
View article: Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study
Circulating short-chain and branched short-chain fatty acids and the risk of incident type 2 diabetes: findings from the 4C study Open
Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with inciden…
View article: Diabetes in China part 2: prevention, challenges, and progress
Diabetes in China part 2: prevention, challenges, and progress Open
During the past 40 years, the prevalence of diabetes in China has increased from less than 1·0% in 1980 to 12·4% in 2018, an increase in line with the rapid growth of the nation's economy. To address such a burden, the Healthy China 2030 i…
View article: Diabetes in China part 1: epidemiology and risk factors
Diabetes in China part 1: epidemiology and risk factors Open
The prevalence of diabetes in China is rapidly increasing. China now has the largest number of people living with diabetes worldwide, accounting for approximately one-quarter of the global diabetes population. Since the late 1970s, China h…
View article: Reducing inequity through tackling social determinants of cardiovascular diseases in China
Reducing inequity through tackling social determinants of cardiovascular diseases in China Open
Guang Ning and colleagues underline the importance of tackling social determinants and associated inequity in prevention and management of cardiovascular diseases
View article: Sex Difference and Socioeconomic Inequity in Chinese People With Hypertension: National Cross-Sectional Survey Study
Sex Difference and Socioeconomic Inequity in Chinese People With Hypertension: National Cross-Sectional Survey Study Open
Background Sex differences in blood pressure (BP) levels and hypertension are important and the role of socioeconomic status (SES) in sex differences in hypertension remains unclear. Objective This study aimed to evaluate the impact of SES…
View article: The Effect of SGLT2 Inhibition on Brain-related Phenotypes and Aging: A Drug Target Mendelian Randomization Study
The Effect of SGLT2 Inhibition on Brain-related Phenotypes and Aging: A Drug Target Mendelian Randomization Study Open
Introduction An observational study suggested sodium-glucose cotransporter 2 (SGLT2) inhibitors might promote healthy aging. However, whether brain-related phenotypes mediate this association is still a question. We applied Mendelian rando…
View article: Gender Disparities in the Association Between Educational Attainment and Cardiovascular-Kidney-Metabolic Syndrome: Cross-Sectional Study
Gender Disparities in the Association Between Educational Attainment and Cardiovascular-Kidney-Metabolic Syndrome: Cross-Sectional Study Open
Background Cardiovascular-kidney-metabolic (CKM) health is affected by social determinants of health, especially education. CKM syndrome has not been evaluated in Chinese population, and the association of education with CKM syndrome in di…
View article: Hepatic Dyrk1b impairs systemic glucose homeostasis by modulating Wbp2 expression in a kinase activity-dependent manner
Hepatic Dyrk1b impairs systemic glucose homeostasis by modulating Wbp2 expression in a kinase activity-dependent manner Open
Patients with gain-of-function mutations of Dyrk1b have higher fasting blood glucose (FBG) levels. However, the role of Dyrk1b in glucose metabolism is not fully elucidated. Herein, we found that hepatic Dyrk1b overexpression in mice impai…
View article: Corrigendum to: The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study
Corrigendum to: The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study Open
Background/Aims: Necrotizing pancreatitis (NP) presents a more severe clinical trajectory and increased mortality compared to edematous pancreatitis. Prompt identification of NP is vital for patient prognosis. A risk prediction model for N…
View article: Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study
Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study Open
Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationw…
View article: The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data
The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data Open
We evaluated the effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on prostate cancer by evidence triangulation. Using Mendelian randomization, we found that genetically proxied SGLT2 inhibition reduced the risk of overall (odds …
View article: Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey
Remnant cholesterol is more positively related to diabetes, prediabetes, and insulin resistance than conventional lipid parameters and lipid ratios: A multicenter, large sample survey Open
Background Not many large‐sample investigations are available that compare the potency of the relationship of remnant cholesterol (RC) and other lipid parameters with diabetes and prediabetes. The goals of our study are to discover the rel…
View article: Clinical characteristics and complication risks in data‐driven clusters among Chinese community diabetes populations
Clinical characteristics and complication risks in data‐driven clusters among Chinese community diabetes populations Open
Background Novel diabetes phenotypes were proposed by the Europeans through cluster analysis, but Chinese community diabetes populations might exhibit different characteristics. This study aims to explore the clinical characteristics of no…
View article: Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study
Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study Open
Context Emerging studies have revealed associations between dietary medium-chain fatty acids (MCFAs) and glucose homeostasis. However, the relationship between serum MCFAs and the incidence of diabetes, and potential interactions with gene…