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View article: COMPARISON OF PERCEPTION FOR THE GINGIVAL DISPLAY BETWEEN DENTAL PROFESSIONALS AND NON-PROFESSIONALS
COMPARISON OF PERCEPTION FOR THE GINGIVAL DISPLAY BETWEEN DENTAL PROFESSIONALS AND NON-PROFESSIONALS Open
OBJECTIVES This study aimed to compare the mean perception scores of gingival display between dental professionals and non-professionals. METHODOLOGY A comparative cross-sectional study was conducted at Rehmat Memorial Hospital, Abbottabad…
View article: Preliminary analysis of short-term real-world outcomes of telitacicept in high-risk IgA nephropathy
Preliminary analysis of short-term real-world outcomes of telitacicept in high-risk IgA nephropathy Open
Introduction IgA nephropathy (IgAN) represents an important cause of end-stage kidney disease worldwide. Telitacicept has demonstrated potential in attenuating disease progression in IgAN patients. However, whether its efficacy differs bet…
View article: Transforming Alzheimer’s disease nursing: integrating holistic care, innovative interventions, and evidence-based practices for enhanced patient outcomes
Transforming Alzheimer’s disease nursing: integrating holistic care, innovative interventions, and evidence-based practices for enhanced patient outcomes Open
Background Alzheimer’s disease (AD) represents a significant global healthcare challenge with increasing prevalence in aging populations. Traditional care models often focus primarily on symptom management with insufficient attention to ho…
View article: Automated multi‐regional <scp>IHC</scp> scoring enhances prognostication in colorectal cancer
Automated multi‐regional <span>IHC</span> scoring enhances prognostication in colorectal cancer Open
The tumor immune microenvironment plays a critical role in colorectal cancer (CRC) prognosis. However, most studies assess a limited set of immune markers manually in the tumor region, without considering immune heterogeneity across multip…
View article: The collecting effect of rhodotorula rubra on cassiterite and co-existing minerals
The collecting effect of rhodotorula rubra on cassiterite and co-existing minerals Open
This study investigated the novel application of Rhodotorula rubra as a bio-based collector for selective flotation separation of cassiterite from co-existing minerals, quartz and calcite. Under optimal conditions (Rhodotorula rubra suspen…
View article: KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression Open
Histone lactylation is a novel epigenetic modification derived from lactate, but its role and mechanism in KRAS mutant colorectal cancer (CRC) progression remains to be fully elucidated. In this study, we first showed that mutant KRAS incr…
View article: ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7 Open
Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (…
View article: Pleiotrophin promote glioma proliferation and invasion by enhancing NF-κB/SLUG mediated epithelial–mesenchymal transition
Pleiotrophin promote glioma proliferation and invasion by enhancing NF-κB/SLUG mediated epithelial–mesenchymal transition Open
PTN plays a crucial role in glioma progression by regulating cell proliferation, migration, invasion, and EMT through the NF-κB pathway. PTN may serve as an important prognostic biomarker and therapeutic target in glioma treatment.
View article: Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells
Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells Open
Background The majority of patients treated with immunotherapy as a standalone therapy experience little to no benefits. Tubulin tyrosine ligase 12 (TTLL12), as a member of the tubulin tyrosine ligase protein family, is associated with the…
View article: STAT1 mediates the pro-inflammatory role of GBP5 in colitis
STAT1 mediates the pro-inflammatory role of GBP5 in colitis Open
Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate the mechanism underlying the pro-inflammatory role of GBP5. We observe that loss …
View article: Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer Open
c-Myc (Myc)-driven cancers exhibit aggressive phenotypes and therapeutic resistance. Here, integrating CRISPR-Cas9 screening, we identify dihydroorotate dehydrogenase (DHODH) as a promising target in Myc-driven cancer. Mechanistically, DHO…
View article: Characteristics of mismatched eplets affecting de novo donor-specific antibody production and antibody-mediated rejection after kidney transplantation
Characteristics of mismatched eplets affecting de novo donor-specific antibody production and antibody-mediated rejection after kidney transplantation Open
De novo donor-specific antibody (dnDSA) generation is the most important marker of antibody-mediated rejection (AMR). However, not all dnDSAs induce AMR. The effects of mismatched eplets on dnDSA production and the occurrence AMR remain co…
View article: Compatibilization and reinforcement of highly filled wood flour/polyethylene composites via peroxide‐induced grafting and crosslinking
Compatibilization and reinforcement of highly filled wood flour/polyethylene composites via peroxide‐induced grafting and crosslinking Open
The industrialized development of biocomposites effectively promotes the high‐value utilization of waste biomass resources, generating substantial economic benefits. However, in highly filled systems (≥50 wt.%), wood flour agglomeration an…
View article: Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway
Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway Open
Our results suggest that exercise can induce the production of Lac-Phe, which plays a preventive role against dextran sulfate sodium-induced colitis in mice. Lac-Phe mitigates colitis through inhibition of the polarization of M1 macrophage…
View article: Glutamic-pyruvic transaminase 1 deficiency–mediated metabolic reprogramming facilitates colorectal adenoma-carcinoma progression
Glutamic-pyruvic transaminase 1 deficiency–mediated metabolic reprogramming facilitates colorectal adenoma-carcinoma progression Open
The tumorigenesis of colorectal cancer (CRC) often follows the normal-adenoma-carcinoma (N-A-C) sequence. However, the molecular mechanisms underlying colorectal adenoma carcinogenesis remain largely unknown. Here, we analyzed transcriptom…
View article: Interleukin-10 deficiency suppresses colorectal cancer metastasis by enriching gut Parabacteroides distasonis
Interleukin-10 deficiency suppresses colorectal cancer metastasis by enriching gut Parabacteroides distasonis Open
These findings demonstrate the significance of IL-10 deficiency in suppressing CRC metastasis through the 4-HPPA-AHR-VEGFA axis mediated by gut P. distasonis, suggesting that P. distasonis or 4-HPAA supplementation could offer a promising …
View article: Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease
Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease Open
Hyperplasia of mesenteric tissues in Crohn's disease, called creeping fat (CrF), is associated with surgical recurrence. Although microbiota translocation and colonization have been found in CrF, convincing mouse phenotypes and the underly…
View article: Systematic lineage tracing unveils polyclonal origin and evolution in colorectal precancer
Systematic lineage tracing unveils polyclonal origin and evolution in colorectal precancer Open
Data and code for Systematic lineage tracing unveils polyclonal origin and evolution in colorectal precancer: This dataset contains reproducibility, pipeline and data for 4 parts of the paper, including PacBio data analysis, scRNA-seq data…
View article: Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer
Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer Open
Resistance to neoadjuvant chemotherapy leads to poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration of therapeutic strategies to improve clinical outcomes. Here, we …
View article: ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis Open
Background Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD), which still lacks of reliable markers and therapeutic options. Cellular senescence has been considered an important mechanism of intestinal fibros…
View article: Systematic lineage mapping uncovers polyclonal-to-monoclonal preneoplastic evolution
Systematic lineage mapping uncovers polyclonal-to-monoclonal preneoplastic evolution Open
Data and code for Systematic lineage mapping uncovers polyclonal-to-monoclonal preneoplastic evolution: This dataset contains reproducibility, pipeline and data for 4 parts of the paper, including PacBio data analysis, scRNA-seq data analy…
View article: MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer Open
Background The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of leucine and isovaleric acid. The molecular mechanisms and prognostic value still need to be ex…
View article: Y-box protein-1 modulates circSPECC1 to promote glioma tumorigenesis via miR-615-5p/HIP1/AKT axis
Y-box protein-1 modulates circSPECC1 to promote glioma tumorigenesis via miR-615-5p/HIP1/AKT axis Open
Y-box binding protein-1 (YB-1) is upregulated in glioma and plays an important role in its occurrence and drug resistance. However, the involved regulatory processes and downstream pathways are still unclear. Since various circular RNAs (c…
View article: Baseline gut microbiome features prior to SARS‐CoV‐2 infection are associated with host symptoms in and post COVID‐19
Baseline gut microbiome features prior to SARS‐CoV‐2 infection are associated with host symptoms in and post COVID‐19 Open
The human gut microbiome varies substantially across individuals and populations and differentially tames our immunity at steady‐state. Hence, we hypothesize that the large heterogeneity of gut microbiomes at steady‐state may shape our bas…