Xiaodong Sun
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View article: Choroidal changes correlate with type 1 neovascular activity in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
Choroidal changes correlate with type 1 neovascular activity in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy Open
Purpose To investigate the association among choroidal factors and lesion activity of polypoidal choroidal vasculopathy (PCV) and type I neovascular age-related macular degeneration (nAMD) using swept-source optical coherence tomography an…
View article: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa
Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa Open
To the best of our knowledge, this work demonstrates for the first time that a gene augmentation approach can restore vision and preserves photoreceptors in an animal model of CNGA1-RP. These findings pave the way for future development of…
View article: Molecular marker discovery and detection for blinding eye disease
Molecular marker discovery and detection for blinding eye disease Open
Accurate, sensitive, and specific detection of molecular markers in intraocular fluid will facilitate the early discovery, diagnosis, and intervention of eye diseases. In this study, a total of 168 participants were recruited and divided i…
View article: Permeability enhancement simulation of hydraulic fracturing in underlying coal seams in goaf
Permeability enhancement simulation of hydraulic fracturing in underlying coal seams in goaf Open
The mining of No.3 coal at Sihe Mine has created a large area of goaf, which has led to a large-scale pressure relief of No.15 coal. It has the advantageous conditions for the development of coalbed methane (CBM). To better achieve the eff…
View article: Plain language summary of publication of the 48-week results from the PULSAR study investigating how well a new dose of aflibercept works and how safe it is for people with wet age-related macular degeneration
Plain language summary of publication of the 48-week results from the PULSAR study investigating how well a new dose of aflibercept works and how safe it is for people with wet age-related macular degeneration Open
What is this summary about? • This is a summary of a publication about the PULSAR study, which was published in The Lancet scientific journal. • Wet age-related macular degeneration (or AMD) is a long-term eye disease in which abnormal blo…
View article: Associations between organophosphorus pesticides exposure and age-related macular degeneration risk in U.S. adults: analysis from interpretable machine learning approaches
Associations between organophosphorus pesticides exposure and age-related macular degeneration risk in U.S. adults: analysis from interpretable machine learning approaches Open
AIM: To investigate the associations between urinary dialkyl phosphate (DAP) metabolites of organophosphorus pesticides (OPPs) exposure and age-related macular degeneration (AMD) risk. METHODS: Participants were drawn from the National Hea…
View article: Effect of Geostress Variation on Hydraulic Fracturing Behavior and Stress Redistribution in Coal Seam Roofs
Effect of Geostress Variation on Hydraulic Fracturing Behavior and Stress Redistribution in Coal Seam Roofs Open
A comprehensive understanding of hydraulic fracturing behavior and its impact on regional stress distribution under varying principal stress conditions is essential for preventing dynamic disasters. In this study, true triaxial hydraulic f…
View article: SR-B1 deficiency suppresses progression in acute myeloid leukemia via ferroptosis and reverses resistance to venetoclax
SR-B1 deficiency suppresses progression in acute myeloid leukemia via ferroptosis and reverses resistance to venetoclax Open
Increase of immature myeloid cells in the bone marrow drives the development of acute myeloid leukemia (AML). The study aimed to clarify the biological function and regulatory mechanism of scavenger receptor class B type 1 (SR-B1) in AML, …
View article: The clinical safety landscape for ocular AAV gene therapies: A systematic review and meta-analysis
The clinical safety landscape for ocular AAV gene therapies: A systematic review and meta-analysis Open
Adeno-associated virus (AAV) gene therapy is a promising approach for treating ocular monogenic or acquired diseases, though immunogenicity and safety remain critical considerations. We conducted a systematic review of 120 trials and 32 pu…
View article: A LASSO-derived model for the prediction of nonattainment of target LDL-C reduction with PCSK9 inhibitors in patients with atherosclerotic cardiovascular disease
A LASSO-derived model for the prediction of nonattainment of target LDL-C reduction with PCSK9 inhibitors in patients with atherosclerotic cardiovascular disease Open
This study presents a LASSO-derived predictive model that can be used to predict the risk of NTR-LDLC with PCSK9 inhibitors in patients with ASCVD.
View article: Endothelial protein C receptor promotes retinal neovascularization through heme catabolism
Endothelial protein C receptor promotes retinal neovascularization through heme catabolism Open
Pathological retinal neovascularization (RNV) is one of the leading causes of blindness worldwide; however, its underlying mechanism remains unclear. Here, we found that the expression of endothelial protein C receptor (Epcr) was increased…
View article: <scp>circSIRT2</scp>/<scp>miR</scp>‐542‐3p/<scp>VASH1</scp> axis regulates endothelial‐to‐mesenchymal transition (<scp>EndMT</scp>) in subretinal fibrosis in age‐related macular degeneration models
<span>circSIRT2</span>/<span>miR</span>‐542‐3p/<span>VASH1</span> axis regulates endothelial‐to‐mesenchymal transition (<span>EndMT</span>) in subretinal fibrosis in age‐related macular degeneration models Open
Neovascular age‐related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading causes of severe visual impairment and irreversible vision loss around the world. Subretinal fibrosis (SRF) con…
View article: Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation
Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation Open
Faricimab up to Q16W showed durable efficacy in the LUCERNE China subpopulation, consistent with global findings. Faricimab may reduce treatment burden for patients with nAMD in China, without compromising efficacy.
View article: Robust multi‐objective optimisation of an axial‐radial flux hybrid excitation permanent magnet synchronous motors based on improved sequential Taguchi method
Robust multi‐objective optimisation of an axial‐radial flux hybrid excitation permanent magnet synchronous motors based on improved sequential Taguchi method Open
This paper proposes a novel axial‐radial flux hybrid excitation permanent magnet synchronous motor (ARFHE‐PMSM), which has better space utilisation and torque density than traditional radial flux PMSM (RFPMM) and axial flux PMSM (AFPMSM). …
View article: Understanding frailty: a qualitative study of older heart failure patients’ frail experience and perceptions of healthcare professionals with frailty
Understanding frailty: a qualitative study of older heart failure patients’ frail experience and perceptions of healthcare professionals with frailty Open
Both elderly patients with HF and HPs described frailty as a state of predicament, involving being caught in life difficulties and falling into a treatment dilemma. Due to the overlap of symptoms and evaluating indicators between frailty a…
View article: Analysis of biofluid metabolomic profiles to the discovery of biomarkers in age-related macular degeneration
Analysis of biofluid metabolomic profiles to the discovery of biomarkers in age-related macular degeneration Open
Objective Age-related macular degeneration (AMD) is one of the leading causes of irreversible visual impairment and blindness in the elderly. As AMD is a multifactorial disease, it is critical to explore useful biomarkers and pathological …
View article: Efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in unresectable primary liver cancer
Efficacy and safety of transhepatic arterial chemoembolization with drug-loaded microspheres in unresectable primary liver cancer Open
BACKGROUND Transhepatic arterial chemoembolization (TACE), as a local treatment, has been widely used in the treatment of unresectable liver cancer. The introduction of drug carrier microspheres has brought new hope for the therapeutic eff…
View article: Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration Open
JOURNAL/nrgr/04.03/01300535-202601000-00043/figure1/v/2025-06-09T151909Z/r/image-tiff Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss. Fe…
View article: Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022
Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022 Open
AIM: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. METHODS: All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Sc…