Lance B. Price
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View article: Identification of genetic determinants that drive population differentiation and host adaptation in Campylobacter jejuni in California
Identification of genetic determinants that drive population differentiation and host adaptation in Campylobacter jejuni in California Open
Campylobacter jejuni is a commensal bacterium that colonizes livestock and wild animals and is responsible for more than 80% of campylobacteriosis cases in humans, which all ultimately have an animal source. Its high genome plasticity and …
View article: Triazole Resistance and Misidentification of <i>Aspergillus tubingensis</i> in Southern California
Triazole Resistance and Misidentification of <i>Aspergillus tubingensis</i> in Southern California Open
Importance Accurate species identification and antifungal susceptibility testing are essential for effective aspergillosis treatment. However, non –Aspergillus fumigatus species, such as Aspergillus tubingensis , are often misidentified an…
View article: Zoonotic <i>Escherichia coli</i> and urinary tract infections in Southern California
Zoonotic <i>Escherichia coli</i> and urinary tract infections in Southern California Open
Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause of urinary tract infections (UTIs) worldwide and may be transmitted from food animals to humans via contaminated meat. However, the contribution of zoonotic ExPEC str…
View article: Assessing the potential impacts of California Senate Bill 27 (SB27) on the antimicrobial susceptibility of <i>Escherichia coli</i> from raw meat
Assessing the potential impacts of California Senate Bill 27 (SB27) on the antimicrobial susceptibility of <i>Escherichia coli</i> from raw meat Open
Our findings suggest that the downward trends in antimicrobial resistance among E. coli populations from California-produced chicken products reflect national trends. It is possible that the California SB27 legislation helped motivate indu…
View article: Predicting sepsis mortality into an era of pandrug-resistant E. coli through modeling
Predicting sepsis mortality into an era of pandrug-resistant E. coli through modeling Open
Background Infections caused by antibiotic-resistant bacteria are increasingly frequent, burdening healthcare systems worldwide. As pathogens acquire resistance to all known antibiotics – i.e., become pan-resistant – treatment of the assoc…
View article: <i>Escherichia coli</i> ST117: exploring the zoonotic hypothesis
<i>Escherichia coli</i> ST117: exploring the zoonotic hypothesis Open
Extraintestinal pathogenic Escherichia coli (ExPEC) can lead to severe infections, with additional risks of increasing antimicrobial resistance rates. Genotypic similarities between ExPEC and avian pathogenic E. coli (APEC) support a possi…
View article: Pediatric urinary tract infections caused by poultry-associated <i>Escherichia coli</i>
Pediatric urinary tract infections caused by poultry-associated <i>Escherichia coli</i> Open
Escherichia coli is the leading cause of urinary tract infections (UTIs) in children and adults. The gastrointestinal tract is the primary reservoir of uropathogenic E. coli , which can be acquired from a variety of environmental exposures…
View article: Gut microbiome predictors of Escherichia coli sequence type 131 colonization and loss
Gut microbiome predictors of Escherichia coli sequence type 131 colonization and loss Open
This work was supported in part by National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award numbers R21AI117654 and UM1AI104681 and the Office of Research and Development, Department of Veteran…
View article: Distance and destination of retail meat alter multidrug resistant contamination in the United States food system
Distance and destination of retail meat alter multidrug resistant contamination in the United States food system Open
Antibiotic-resistant infections are a global concern, especially those caused by multidrug-resistant (MDR) bacteria, defined as those resistant to more than three drug classes. The animal agriculture industry contributes to the antimicrobi…
View article: Plugging the leaks: antibiotic resistance at human–animal interfaces in low‐resource settings
Plugging the leaks: antibiotic resistance at human–animal interfaces in low‐resource settings Open
Antibiotic resistance is one of the greatest public health challenges of our time. International efforts to curb resistance have largely focused on drug development and limiting unnecessary antibiotic use. However, in areas where water, sa…
View article: Impact of California’s Senate Bill 27 on Antimicrobial-Resistant Escherichia coli Urinary Tract Infection in Humans: Protocol for a Study of Methods and Baseline Data
Impact of California’s Senate Bill 27 on Antimicrobial-Resistant Escherichia coli Urinary Tract Infection in Humans: Protocol for a Study of Methods and Baseline Data Open
Background Overuse of antibiotics contributes to antimicrobial resistance (AMR) and is a growing threat to human health worldwide. Previous work suggests a link between antimicrobial use in poultry and human AMR extraintestinal pathogenic …
View article: Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections Open
A one-health perspective may provide new and actionable information about Escherichia coli transmission. E. coli colonizes a broad range of vertebrates, including humans and food-production animals, and is a leading cause of bladder, kidne…
View article: Impact of a Statewide Livestock Antibiotic Use Policy on Resistance in Human Urine <i>Escherichia coli</i> Isolates: A Synthetic Control Analysis
Impact of a Statewide Livestock Antibiotic Use Policy on Resistance in Human Urine <i>Escherichia coli</i> Isolates: A Synthetic Control Analysis Open
Further research is needed to determine the role of SB27 in the observed reduction in ESC resistance E. coli in human populations, particularly as additional states implement similar legislation. https://doi.org/10.1289/EHP11221.
View article: Integrating sample similarities into latent class analysis: a tree‐structured shrinkage approach
Integrating sample similarities into latent class analysis: a tree‐structured shrinkage approach Open
This paper is concerned with using multivariate binary observations to estimate the probabilities of unobserved classes with scientific meanings. We focus on the setting where additional information about sample similarities is available a…
View article: Contamination of Retail Meat Samples with Multidrug-Resistant Organisms in Relation to Organic and Conventional Production and Processing: A Cross-Sectional Analysis of Data from the United States National Antimicrobial Resistance Monitoring System, 2012–2017
Contamination of Retail Meat Samples with Multidrug-Resistant Organisms in Relation to Organic and Conventional Production and Processing: A Cross-Sectional Analysis of Data from the United States National Antimicrobial Resistance Monitoring System, 2012–2017 Open
Organically produced and processed retail meat samples had a significantly lower prevalence of MDRO than conventionally produced and processed samples had, whereas meat from split processors had a lower prevalence of any contamination than…
View article: Leakiness at the human-animal interface in Southeast Asia and implications for the spread of antibiotic resistance
Leakiness at the human-animal interface in Southeast Asia and implications for the spread of antibiotic resistance Open
International efforts to curb antimicrobial resistance have focused on drug development and limiting unnecessary use. However, in areas where water, sanitation, and hygiene infrastructure is lacking, and where biosecurity in food-animal pr…
View article: Transmission of Antimicrobial-Resistant <i>Staphylococcus aureus</i> Clonal Complex 9 between Pigs and Humans, United States
Transmission of Antimicrobial-Resistant <i>Staphylococcus aureus</i> Clonal Complex 9 between Pigs and Humans, United States Open
Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 3…
View article: Integrating Sample Similarities into Latent Class Analysis: A Tree-Structured Shrinkage Approach
Integrating Sample Similarities into Latent Class Analysis: A Tree-Structured Shrinkage Approach Open
S ummary This paper is concerned with using multivariate binary observations to estimate the probabilities of unobserved classes with scientific meanings. We focus on the setting where additional information about sample similarities is av…
View article: Social, cultural and economic aspects of antimicrobial resistance
Social, cultural and economic aspects of antimicrobial resistance Open
"The COVID-19 pandemic has taught us the terrible cost of being unprepared for global health emergencies. The lack of treatments, vaccines, and sufficiently coordinated responses resulted in many unprecedented challenges that must now be a…
View article: Livestock-Associated Methicillin and Multidrug Resistant Staphylococcus aureus Is Present among Industrial, Not Antibiotic-Free Livestock Operation Workers in North Carolina
Livestock-Associated Methicillin and Multidrug Resistant Staphylococcus aureus Is Present among Industrial, Not Antibiotic-Free Livestock Operation Workers in North Carolina Open
Administration of antibiotics to food animals may select for drug-resistant pathogens of clinical significance, such as methicillin-resistant Staphylococcus aureus (MRSA). In the United States, studies have examined prevalence of MRSA carr…
View article: Multidrug-Resistant and Methicillin-Resistant Staphylococcus aureus (MRSA) in Hog Slaughter and Processing Plant Workers and Their Community in North Carolina (USA)
Multidrug-Resistant and Methicillin-Resistant Staphylococcus aureus (MRSA) in Hog Slaughter and Processing Plant Workers and Their Community in North Carolina (USA) Open
Background: Use of antimicrobials in industrial food-animal production is associated with the presence of antimicrobial-resistant Staphylococcus aureus (S. aureus) among animals and humans. Hog slaughter/processing plants process large num…
View article: Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant<i>Staphylococcus aureus</i>in Humans
Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant<i>Staphylococcus aureus</i>in Humans Open
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, an…
View article: Identification of Host-Specific Gene Elements in E. coli
Identification of Host-Specific Gene Elements in E. coli Open
Extra intestinal pathogenic E. coli causes a public health burden by causing infections which can lead to deaths by sepsis. These are commonly found to colonize food animals and are present in retail meat as a contaminant. There is an urge…
View article: Bayesian latent class analysis of mobile genetic elements for identification of zoonotic spillover and host switch events
Bayesian latent class analysis of mobile genetic elements for identification of zoonotic spillover and host switch events Open
Background: Extraintestinal pathogenic Escherichia coli causes millions of urinary tract infections and nearly 40,000 sepsis deaths each year in the United States. Accessory genetic elements may provide information regarding host origin of…
View article: Emergence of Enteroaggregative Escherichia coli within the ST131 Lineage as a Cause of Extraintestinal Infections
Emergence of Enteroaggregative Escherichia coli within the ST131 Lineage as a Cause of Extraintestinal Infections Open
E. coli ST131 is an important extraintestinal pathogenic lineage. A signature characteristic of ST131 is its ability to asymptomatically colonize the gastrointestinal tract and then opportunistically cause extraintestinal infections, such …