Lance E. Keller
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AliC and AliD of nonencapsulated Streptococcus pneumoniae enhance virulence in a Galleria mellonella model of infection by contributing to reactive oxygen species resistance Open
Introduction Nonencapsulated Streptococcus pneumoniae (NESp) are isolated worldwide. Due to the lack of capsule in NESp strains the current vaccines, that target the pneumococcal capsule are ineffective. Some NESp contain the oligopeptide …
View article: An abundance of aliC and aliD genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity
An abundance of aliC and aliD genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity Open
Pneumococcal surveillance studies are reporting increasing prevalence of non-encapsulated pneumococci (NESp). NESp are an important reservoir for genetic exchange among streptococci, including for antimicrobial resistance, and are increasi…
An Abundance of aliC and aliD Genes Was Identified in Saliva Using a Novel Multiplex qPCR to Characterize Group II Non-Encapsulated Pneumococci With Improved Specificity Open
BACKGROUND: Surveillance of pneumococcus is reporting increasing prevalence of non-encapsulated pneumococci (NESp). NESp are an important reservoir for genetic exchange among streptococci, including for antimicrobial resistance (AMR), and …
View article: An abundance of <i>aliC</i> and <i>aliD</i> genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity
An abundance of <i>aliC</i> and <i>aliD</i> genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity Open
Background Surveillance of pneumococcus is reporting increasing prevalence of non-encapsulated pneumococci (NESp). NESp are an important reservoir for genetic exchange among streptococci, including for antimicrobial resistance (AMR), and a…
Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci Open
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumo…
View article: Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance by <i>Streptococcus pneumoniae</i>
Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance by <i>Streptococcus pneumoniae</i> Open
Aim Streptococcus pneumoniae (Spn) acquires genes for macrolide resistance, MEGA or ermB , in the human host. These genes are carried either in the chromosome, or on integrative conjugative elements (ICEs). Here, we investigated molecular …
Molecular and Structural Basis of Oligopeptide Recognition and Transport by the Ami Transporter System in Pneumococci Open
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumo…
Nonencapsulated <i>Streptococcus pneumoniae</i> avoid innate immunity clearance through reactive oxygen species resistance Open
Neutrophils provide an important mechanism of clearance for Streptococcus pneumoniae. Therefore, evasion of the innate immune response is essential for pneumococci to cause disease. The pneumococcal capsule is protective against phagocytos…
Oligopeptide Transporters of Nonencapsulated Streptococcus pneumoniae Regulate CbpAC and PspA Expression and Reduce Complement-Mediated Clearance Open
Streptococcus pneumoniae (pneumococcus) can cause a range of diseases. Although there is a robust pneumococcal vaccination program that reduces invasive pneumococcal disease by targeting various polysaccharide capsules, there has been an i…
Three New Integration Vectors and Fluorescent Proteins for Use in the Opportunistic Human Pathogen Streptococcus pneumoniae Open
Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), em…
Three new integration vectors and fluorescent proteins for use in the opportunistic human pathogen <i>Streptococcus pneumoniae</i> Open
Here we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae . The constructed vectors, named PEP for Pneumococcal Engineering Platform, employ a…
Increased Virulence of an Encapsulated Streptococcus pneumoniae Upon Expression of Pneumococcal Surface Protein K Open
PspK increases pneumococcal virulence during pneumonia and OM. PspK also partially compensates for loss of virulence in the absence of capsule. Additionally, PspK provides a selective advantage in a competitive environment. Therefore, acqu…
Mucosal Infections and Invasive Potential of Nonencapsulated <i>Streptococcus pneumoniae</i> Are Enhanced by Oligopeptide Binding Proteins AliC and AliD Open
Nonencapsulated Streptococcus pneumoniae (NESp) is an emerging human pathogen that colonizes the nasopharynx and is associated with noninvasive diseases such as otitis media (OM), conjunctivitis, and nonbacteremic pneumonia. Since capsule …
View article: Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae
Polyamine transporter potABCD is required for virulence of encapsulated but not nonencapsulated Streptococcus pneumoniae Open
Streptococcus pneumoniae is commonly found in the human nasopharynx and is the causative agent of multiple diseases. Since invasive pneumococcal infections are associated with encapsulated pneumococci, the capsular polysaccharide is the ta…
Surface Proteins and Pneumolysin of Encapsulated and Nonencapsulated Streptococcus pneumoniae Mediate Virulence in a Chinchilla Model of Otitis Media Open
Streptococcus pneumoniae infections result in a range of human diseases and are responsible for almost one million deaths annually. Pneumococcal disease is mediated in part through surface structures and an anti-phagocytic capsule. Recent …
View article: Nonencapsulated Streptococcus pneumoniae: Emergence and Pathogenesis
Nonencapsulated Streptococcus pneumoniae: Emergence and Pathogenesis Open
While significant protection from pneumococcal disease has been achieved by the use of polysaccharide and polysaccharide-protein conjugate vaccines, capsule-independent protection has been limited by serotype replacement along with disease…
AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness Open
Across bacterial species, metal binding proteins can serve functions in pathogenesis in addition to regulating metal homeostasis. We have compared and contrasted the activities of zinc (Zn2+)-binding lipoproteins AdcA and AdcAII in the Str…
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis Open
Streptococcus pneumoniae is an important human pathogen. To cause disease, it must first colonize the nasopharynx. The widespread use of pneumococcal-conjugate vaccines which target the capsular polysaccharide has led to decreased nasophar…