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View article: 787 AB598, a CD39 inhibitory antibody, promotes immune-mediated tumor control
787 AB598, a CD39 inhibitory antibody, promotes immune-mediated tumor control Open
Background AB598 inhibits the enzymatic activity of CD39, the dominant ATPase in the tumor microenvironment (TME). CD39 inhibition allows ATP levels to rise locally, leading to the activation of myeloid cells, increased tumor-specific acti…
View article: 689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellular Mechanism of Action
689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellular Mechanism of Action Open
Background We have previously demonstrated adaptive antibody responses targeting public tumor antigens in cancer patients. ATRC-101, a clinical stage, engineered version of an antibody identified in such a patient, displays robust single-a…
View article: Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal
Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal Open
How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustainable tissue regeneration is not well understood. A major roadblock to understanding satellite cell fate decisions has been the difficulty …
View article: Heterogeneity of satellite cells implicates DELTA1/NOTCH2 signaling in self-renewal
Heterogeneity of satellite cells implicates DELTA1/NOTCH2 signaling in self-renewal Open
SUMMARY How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustainable tissue regeneration is not well understood. A major roadblock to understanding satellite cell fate decisions has been the dif…
View article: Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy
Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy Open
In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves e…