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View article: Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 1: their emergence from injuries to the donor organ
Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 1: their emergence from injuries to the donor organ Open
This Part 1 of a bipartite review commences with a succinct exposition of innate alloimmunity in light of the danger/injury hypothesis in Immunology. The model posits that an alloimmune response, along with the presentation of alloantigens…
View article: Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 2: implementation strategies
Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 2: implementation strategies Open
This Part 2 of a bipartite review commences with the delineation of a conceptual model outlining the fundamental role of injury-induced regulated cell death (RCD) in the release of DAMPs that drive innate immune responses involved in early…
View article: Walter Brendel and the dawn of transplantation research in Germany
Walter Brendel and the dawn of transplantation research in Germany Open
Walter Brendel was a physiologist who headed the Institut of Experimental Surgery at the University of Munich (LMU) from 1961 until 1989. His legendary career began with the development of an anti-human lymphocyte globulin (ALG) at his Ins…
View article: Approaching the DAMPome: Evolution in Medicine?
Approaching the DAMPome: Evolution in Medicine? Open
The final chapter of the book provides a brief assessment of the current state of DAMPs research. Indeed, new molecules are constantly being discovered that can be qualified as DAMPs or SAMPs, and the discoveries are far from over. Accordi…
View article: Editorial: DAMPs Across the Tree of Life
Editorial: DAMPs Across the Tree of Life Open
EDITORIAL article Front. Immunol., 01 February 2022Sec. Inflammation Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.844315
View article: Editorial: Trauma-Induced, DAMP-Mediated Remote Organ Injury, and Immunosuppression in the Acutely Ill Patient
Editorial: Trauma-Induced, DAMP-Mediated Remote Organ Injury, and Immunosuppression in the Acutely Ill Patient Open
EDITORIAL article Front. Immunol., 20 August 2019Sec. Inflammation Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.01971
View article: Origin and Consequences of Necroinflammation
Origin and Consequences of Necroinflammation Open
When cells undergo necrotic cell death in either physiological or pathophysiological settings in vivo, they release highly immunogenic intracellular molecules and organelles into the interstitium and thereby represent the strongest known t…
View article: Epilogue: How Should Clinicians Implement the Complex Innate Immune Effector Responses at the Patient’s Bedside?
Epilogue: How Should Clinicians Implement the Complex Innate Immune Effector Responses at the Patient’s Bedside? Open
The various facets of innate immune effector responses described in this part, when getting uncontrolled and dysregulated, let intuit their great impact on future modern medicine. Nevertheless, most of these responses are complex and compl…
View article: Epilogue : Cells of Our Immune System: A Whole Army of Defenders Far Beyond T and B Cells
Epilogue : Cells of Our Immune System: A Whole Army of Defenders Far Beyond T and B Cells Open
The Epilogue to Part III is devoted to the issue of reassessing the composition and the facilities of the mammalian immune system: originally thought to consist of T and B lymphocytes and antibodies only capable of defending our body again…
View article: Prologue: The Whole Body as an Immune System
Prologue: The Whole Body as an Immune System Open
All body cells that express pattern recognition molecules to sense MAMPs or DAMPs can be counted as cells of the innate immune defense system in the broader sense. According to new notions, these cells can be divided into groups of mobile/…
View article: Prologue: The “Ready-to-Go” Lymphocytes of the Immune System
Prologue: The “Ready-to-Go” Lymphocytes of the Immune System Open
In the Prologue of Part VII, the typical features of innate lymphoid cells and unconventional T cells with partial innate function are briefly introduced to the reader. So far, three groups of innate lymphoid cells have been classified and…
View article: Epilogue: The Innate Immune System: A Global Player in Health and Disease
Epilogue: The Innate Immune System: A Global Player in Health and Disease Open
This Epilogue exits Part II by stressing that the innate immune system—in particular, regarding its various DAMP-mediated functions—can be seen as a leading global player in health and disease. At first glance, this statement appears to be…
View article: Editorial: Danger Signals Triggering Immune Response and Inflammation
Editorial: Danger Signals Triggering Immune Response and Inflammation Open
EDITORIAL article Front. Immunol., 11 August 2017Sec. Inflammation Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.00979
View article: Editorial: Wound Recognition across the Tree of Life
Editorial: Wound Recognition across the Tree of Life Open
EDITORIAL article Front. Plant Sci., 01 September 2016Sec. Plant Pathogen Interactions Volume 7 - 2016 | https://doi.org/10.3389/fpls.2016.01319