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View article: IL1RL1 asthma risk variants regulate airway type 2 inflammation
IL1RL1 asthma risk variants regulate airway type 2 inflammation Open
Genome-wide association studies of asthma have identified genetic variants in the IL1RL1 gene, but the molecular mechanisms conferring risk are unknown. IL1RL1 encodes the ST2 receptor (ST2L) for IL-33 and an inhibitory decoy receptor (sST…
View article: Alternative splicing of interleukin-33 and type 2 inflammation in asthma
Alternative splicing of interleukin-33 and type 2 inflammation in asthma Open
Significance Type 2 inflammation occurs in a large subgroup of asthmatics and is the target of multiple novel therapies for asthma; however, the mechanisms that drive type 2 inflammation in chronic asthma are poorly understood. In this stu…