Explanipedia

Ketone ester ingestion increases exogenous carbohydrate storage and lowers glycemia during post-exercise recovery: a randomised crossover trial Open

Lane L. Clarke, Sophie L. Russell, Bruno Spellanzon, Jennifer Maher, James A. Betts , et al. · 2025

Ketone ester ingestion increases exogenous carbohydrate storage and lowers glycemia during post-exercise recovery; A randomised crossover trial. Open

Lane L. Clarke, Sophie Russell, Bruno Spellanzon, Jennifer Maher, James A. Betts , et al. · 2025

β-hydroxybutyrate can suppress endogenous glucose production, with potential implications for carbohydrate metabolism during post-exercise recovery. The aim of the current study was to assess the effects of ketone ester ingestion during po…

Fecal dysbiosis and inflammation in intestinal-specific Cftr knockout mice on regimens preventing intestinal obstruction Open

Sarah M. Young, Rowena A. Woode, Estela C. Williams, Aaron C. Ericsson, Lane L. Clarke · 2023

Chronic intestinal inflammation is a manifestation of cystic fibrosis (CF), a disease caused by loss of the anion channel CF transmembrane conductance regulator (CFTR) that is expressed in many tissues. This study shows that intestinal epi…

349 Intestinal epithelial-specific Cftr knockout induces fecal dysbiosis and bowel inflammation in mice consuming anti-obstructive dietary regimens Open

Rowena A. Woode, Sarah Young, E. Williams, Aaron C. Ericsson, Lane L. Clarke · 2023

Fecal Dysbiosis and Inflammation in Intestinal-Specific Cftr Knockout Mice on Regimens Preventing Intestinal Obstruction Open

Sarah M. Young, Rowena A. Woode, Estela Williams, Aaron C. Ericsson, Lane L. Clarke · 2023

Chronic intestinal inflammation is a poorly understood manifestation of Cystic Fibrosis (CF), which may be refractory to ion channel CFTR modulator therapy. People with CF exhibit intestinal dysbiosis which has potential for stimulating in…

INTESTINAL EPITHELIAL CELL-SPECIFIC CFTR KNOCKOUT MICE EXHIBIT FECAL MICROBIAL DYSBIOSIS Open

Sarah Young, Aaron C. Ericsson, Rowena A. Woode, Lane L. Clarke · 2022

BACKGROUND Chronic intestinal inflammation is a poorly understood manifestation of Cystic Fibrosis (CF) disease. Fecal microbial dysbiosis has the potential of inducing intestinal inflammation and has been reported in people with CF as wel…

INTESTINAL EPITHELIAL CELL-SPECIFIC CFTR KNOCKOUT MICE EXHIBIT FECAL MICROBIAL DYSBIOSIS Open

Sarah J. Young, Aaron C. Ericsson, Rowena A. Woode, Lane L. Clarke · 2022

Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine Open

Nancy M. Walker, Jinghua Liu, Sarah M. Young, Rowena A. Woode, Lane L. Clarke · 2021

Studies of small intestinal organoids from cystic fibrosis (CF) mice show that goblet cell hyperplasia and increased Toll-like receptor 2/4 expression are not primary manifestations of the CF intestine. Intestinal goblet cell hyperplasia i…

367: Goblet cell-associated antigen passages and tolerogenic dendritic cells are increased in the intestinal-specific CFTR KO mouse intestine Open

Sarah J. Young, K. L. McDonald, Rowena A. Woode, Jill Ford, Rodney D. Newberry , et al. · 2021

Organoids as a Model for Intestinal Ion Transport Physiology Open

Hugo R. de Jonge, Marcel J. C. Bijvelds, Ashlee M. Strubberg, Jinghua Liu, Lane L. Clarke · 2020

A BAC Transgene Expressing Human CFTR under Control of Its Regulatory Elements Rescues Cftr Knockout Mice Open

Lara R. Gawenis, Craig A. Hodges, Daniel R. McHugh, Dana M. Valerio, Alexander Miron , et al. · 2019

Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR would advance in vivo t…

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine Open

Ashlee M. Strubberg, Jinghua Liu, Nancy M. Walker, Casey D. Stefanski, R. John MacLeod , et al. · 2017

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine Open

Ashlee M. Strubberg, Jinghua Liu, Nancy M. Walker, Casey D. Stefanski, R. John MacLeod , et al. · 2017

Background & Aims Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice exhibit augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined …

Reply: Epithelial alkalinity and hyperproliferation in the Cftr KO intestine Open

Nancy M. Walker, Jinghua Liu, Sydney Stein, Ashlee M. Strubberg, Lane L. Clarke · 2016

Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium Open

Nancy M. Walker, Jinghua Liu, Sydney Stein, Casey D. Stefanski, Ashlee M. Strubberg , et al. · 2015

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl − and HCO 3 − efflux across the apical membrane of the epithelium. In the intestine, CF man…

Defective goblet cell exocytosis contributes to murine cystic fibrosis–associated intestinal disease Open

Jinghua Liu, Nancy M. Walker, Akifumi Ootani, Ashlee M. Strubberg, Lane L. Clarke · 2015

Cystic fibrosis (CF) intestinal disease is associated with the pathological manifestation mucoviscidosis, which is the secretion of tenacious, viscid mucus that plugs ducts and glands of epithelial-lined organs. Goblet cells are the princi…

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