Lanfen Chen
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Piezo1 senses hyphae and initiates host defense against pathogenic fungi Open
Candida albicans metamorphoses from benign yeast to a rigid hyphal, becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here, we report that th…
Design of a Vermiculture Device with the Separation Function Open
To address problems of high labor intensity, low efficiency and poor effect in separating earthworms from vermicompost manually, a vermiculture device with the separation function has been proposed. This box-structure device is divided int…
Design of a Self-propelled Precision Powder Sprayer Open
The self-propelled precision powder sprayer has been designed to address problems such as the inaccurate control of the powder, high labor intensity and difficult maintenance of traditional powder sprayers. It has adopted the self-propelle…
View article: Design of an Automatic Cut Chrysanthemum Cultivation Device
Design of an Automatic Cut Chrysanthemum Cultivation Device Open
In practice, flexible nets are applied, but their support to chrysanthemum is insecure, unable to make it keep upright. Especially, when chrysanthemum is in full blossom, it is likely to fall, which has severely affected marketability of c…
Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification Open
Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. Here, we screened an in-house …
View article: SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling
SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling Open
The loss of contact inhibition is a key step during carcinogenesis. The Hippo-Yes-associated protein (Hippo/YAP) pathway is an important regulator of cell growth in a cell density-dependent manner. However, how Hippo signaling senses cell …
Supporting materials and methods from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Detailed description for General Chemistry, Cell culture, Antibodies, Plasmid constructs, Establishment of oncogenic kinase transformed Ba/F3 cells, Generation of BRK, EGFR, HER2 knockdown cell lines, Anti-proliferation assay and enzymatic…
Supporting Figure legends from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Supplementary figure legends
Data from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Approximately 80% of breast cancers overexpress the kinase breast tumor kinase (BRK)/protein tyrosine kinase 6, which has various oncogenic roles in breast cancer cell proliferation, survival, and migration. However, BRK inhibitors have ye…
Data from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Approximately 80% of breast cancers overexpress the kinase breast tumor kinase (BRK)/protein tyrosine kinase 6, which has various oncogenic roles in breast cancer cell proliferation, survival, and migration. However, BRK inhibitors have ye…
Supporting figures 1 through 7 and tables 1 through 3 from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Supplemental Figure S1. The chemical structure of compound 4f. Supplemental Figure S2, related to Figure 2. XMU-MP-2 induces apoptosis in BRK Ba/F3 cells without affecting the survival of the parental Ba/F3 cells. Supplemental Figure S3, r…
Supporting Figure legends from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Supplementary figure legends
Supporting figures 1 through 7 and tables 1 through 3 from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Supplemental Figure S1. The chemical structure of compound 4f. Supplemental Figure S2, related to Figure 2. XMU-MP-2 induces apoptosis in BRK Ba/F3 cells without affecting the survival of the parental Ba/F3 cells. Supplemental Figure S3, r…
Supporting materials and methods from Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors Open
Detailed description for General Chemistry, Cell culture, Antibodies, Plasmid constructs, Establishment of oncogenic kinase transformed Ba/F3 cells, Generation of BRK, EGFR, HER2 knockdown cell lines, Anti-proliferation assay and enzymatic…
A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC Open
More than 60% of nonsmall cell lung cancer (NSCLC) patients show a positive response to the first ALK inhibitor, crizotinib, which has been used as the standard treatment for newly diagnosed patients with ALK rearrangement. However, most p…
[Effect of different melatonin treatment regimens on white matter damage in neonatal rats with hypoxic-ischemic brain damage]. Open
Both SDIT and 7DCT can improve long-term behavior and reduce white matter damage in neonatal rats with HIBD, and 7DCT is more effective than SDIT.
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Open
Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors …
The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction Open
Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide inhibitory…
Editorial: Hippo Signaling in the Immune System Open
EDITORIAL article Front. Immunol., 14 October 2020Sec. Molecular Innate Immunity Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.587514
[Effects of different melatonin treatment regimens on the proliferation of endogenous neural stem cells in neonatal rats with hypoxic-ischemic brain damage]. Open
Both single-dose immediate melatonin treatment and 7-day continuous melatonin treatment can promote the proliferation of endogenous NSCs and alleviate long-term histological injury in the brain of neonatal rats with HIBD. A 7-day continuou…