Langchong He
YOU?
Author Swipe
View article: Protein Structure Prediction Using a New Optimization-Based Evolutionary and Explainable Artificial Intelligence Approach
Protein Structure Prediction Using a New Optimization-Based Evolutionary and Explainable Artificial Intelligence Approach Open
Protein structure prediction (PSP) is an important scientific problem because it helps humans to understand how proteins perform their biological functions. This paper models the PSP problem as a multi-objective optimization problem with t…
View article: Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption
Daphnetin Alleviates Senile and Disuse Osteoporosis by Distinct Modulations of Bone Formation and Resorption Open
Senile and disuse osteoporosis have distinct bone turnover status and lack effective treatments. In this study, senescence-accelerated mouse prone 8 (SAMP8) and hindlimb unloading mouse models were used to explore the protective effects of…
View article: Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells
Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells Open
TDB-6 might be a promising survivin inhibitor with great potential for CRC treatment.
View article: Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study
Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study Open
Introduction In December 2021, a large-scale epidemic broke out in Xi’an, China, due to SARS-CoV-2 infection. This study reports the effect of vaccination on COVID-19 and evaluates the impact of different vaccine doses on routine laborator…
View article: Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion
Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion Open
Fusion with host cell membrane is the main mechanism of infection of SARS-CoV-2. Here, we propose a new strategy to double block SARS-CoV-2 membrane fusion by using Harringtonine (HT), a small-molecule antagonist. By using cell membrane ch…
View article: Novel risk assessment of Cd in earthworms and leeches based on bioavailability through in vitro digestion/Caco-2 and MDCK cells
Novel risk assessment of Cd in earthworms and leeches based on bioavailability through in vitro digestion/Caco-2 and MDCK cells Open
Little data are available about the extent of bio-accumulation of heavy metals in traditional animal medicines (TAMs). In the present study, the oral bioavailability of cadmium (Cd) in earthworms and leeches was investigated through in vit…
View article: Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2
Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2 Open
Since December 2019, the new coronavirus (also known as severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2, 2019‐nCoV])—induced disease, COVID‐19, has spread rapidly worldwide. Studies have reported that the traditional Chinese me…
View article: Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification Open
Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 invades host cells remains poorly understood. Here we used SARS-CoV-2 p…
View article: A novel ELISA method to determine human MrgX2 in chronic urticaria
A novel ELISA method to determine human MrgX2 in chronic urticaria Open
Background Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is upregulated in severe chronic urticaria (CU). Mast cells and leukocytes are key effector …
View article: A novel ELISA method to determine human MrgX2 in chronic urticaria
A novel ELISA method to determine human MrgX2 in chronic urticaria Open
BACKGROUND: Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is upregulated in severe chronic urticaria (CU). Mast cells and leukocytes are key effector…
View article: A Novel Human MrgX2-ELISA Kit to Detect MrgX2 Concentration Associated with Chronic Urticaria
A Novel Human MrgX2-ELISA Kit to Detect MrgX2 Concentration Associated with Chronic Urticaria Open
BACKGROUND: Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is upregulated in severe chronic urticaria (CU). Mast cells and leukocytes are key effector…
View article: <scp>HMQ</scp>‐T‐B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway
<span>HMQ</span>‐T‐B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway Open
Hepatocellular carcinoma ( HCC ) is a highly prevalent cancer worldwide and it is necessary to discover and develop novel preventive strategies and therapeutic approaches for HCC . Herein, we report that EphrinB2 expression is correlated w…
View article: A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer
A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer Open
We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosi…
View article: Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway
Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway Open
Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular, as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R inju…
View article: Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2
Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2 Open
Mast cells are unique immune cells that function as sentinels in host defence reactions, including immediate hypersensitivity responses and allergic responses. The mast cell‐specific receptor named MAS‐related G protein‐coupled receptor X2…
View article: Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling
Imperatorin derivative OW1 inhibits the upregulation of TGF-β and MMP-2 in renovascular hypertension-induced cardiac remodeling Open
Chronic hypertension induces vascular and cardiac remodeling. OW1 is a novel imperatorin derivative that was previously reported to inhibit vascular remodeling and improve kidney function affected by hypertension. In the present study, the…
View article: Sinomenine potentiates P815 cell degranulation via upregulation of Ca<sup>2+</sup> mobilization through the Lyn/PLCγ/IP3R pathway
Sinomenine potentiates P815 cell degranulation via upregulation of Ca<sup>2+</sup> mobilization through the Lyn/PLCγ/IP3R pathway Open
Mast cells are vital mediators of drug allergy and, therefore, studying the relationship between drug allergy and mast cells is essential. Sinomenine is the principal active component of Sinomenium acutum, which has anti-inflammatory and an…
View article: A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of <scp>CXCR</scp>4
A novel biphenyl urea derivate inhibits the invasion of breast cancer through the modulation of <span>CXCR</span>4 Open
The increased migration and invasion of breast carcinoma cells are key events in the development of metastasis to the lymph nodes and distant organs. CXCR 4, the receptor for stromal‐derived factor‐1, is reportedly involved in breast carci…