Florian Läng
YOU?
Author Swipe
View article: Scalable Optical Quantum State Synthesizer with Dual-Mode Resonator Memory
Scalable Optical Quantum State Synthesizer with Dual-Mode Resonator Memory Open
Optical quantum computing is a promising approach for achieving large-scale quantum computation. While Gaussian operations have been successfully scaled, the inherently weak nonlinearity in optics makes generating highly non-Gaussian state…
View article: Hydration and health at ages 40–70 years in Salzburg Austria is associated with a median total water intake over 40 mL/kg including at least 1 L/d plain drinking water
Hydration and health at ages 40–70 years in Salzburg Austria is associated with a median total water intake over 40 mL/kg including at least 1 L/d plain drinking water Open
Introduction To address longstanding questions about how much plain water to drink for hydration and long-term health, this study described the plain water intake (PWI) of people without chronic health conditions (CHC), at ages 40–70 years…
View article: Orthodontic diagnosis and usability of the web-based e-learning application orthotrainer
Orthodontic diagnosis and usability of the web-based e-learning application orthotrainer Open
View article: Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia
Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia Open
Little is known about pregnancies and placental changes in women with glycogen storage disease type Ia (GSD Ia). We report on two primipara with GSD Ia who both developed preeclampsia and whose newborns were small for gestational age. Both…
View article: Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2
Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2 Open
Introduction A transient window of uterine receptivity ensures that embryos implant in an optimal endometrial environment. Failure to establish or premature closure of the implantation window is thought to be a major cause of infertility, …
View article: Validation of a digital, partly automated three-dimensional cast analysis for evaluation of orthodontic treatment assessment
Validation of a digital, partly automated three-dimensional cast analysis for evaluation of orthodontic treatment assessment Open
View article: Soft Focused Shock Wave Treatment of Solid Tumors. Part I: Physico-mechanical Preconditions, Parametric Simulation and Technical Applicator Design
Soft Focused Shock Wave Treatment of Solid Tumors. Part I: Physico-mechanical Preconditions, Parametric Simulation and Technical Applicator Design Open
Purpose To explore the feasibility of targeted impairment of malignant tumors by application of soft focused shock wave treatment, the physico-mechanical preconditions are investigated. This innovative “soft” approach is different from the…
View article: Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development
Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development Open
After menstruation the uterine spiral arteries are repaired through angiogenesis. This process is tightly regulated by the paracrine communication between endometrial stromal cells (EnSCs) and endothelial cells. Any molecular aberration in…
View article: KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures
KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures Open
Low temperatures and cooling agents like menthol induce cold sensation by activating the peripheral cold receptors TRPM8 and TRPA1, cation channels belonging to the TRP channel family, while the reduction of potassium currents provides an …
View article: Excessive endometrial PlGF- Rac1 signalling underlies endometrial cell stiffness linked to pre-eclampsia
Excessive endometrial PlGF- Rac1 signalling underlies endometrial cell stiffness linked to pre-eclampsia Open
View article: Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells
Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1α Activity in Ishikawa and HEC1a Cells Open
Nuclear factor of activated T cells 5 (NFAT5) and cyclooxygenase 2 (COX2; PTGS2) both participate in diverse pathologies including cancer progression. However, the biological role of the NFAT5-COX2 signaling pathway in human endometrial ca…
View article: Paracelsus 10000 data from Austria suggest >1 L/D drinking water for hydration and health into middle-age
Paracelsus 10000 data from Austria suggest >1 L/D drinking water for hydration and health into middle-age Open
View article: Platelet-derived microRNAs play a pivotal role in cardiac remodeling after myocardial ischemia and reperfusion
Platelet-derived microRNAs play a pivotal role in cardiac remodeling after myocardial ischemia and reperfusion Open
Background Platelets can infiltrate ischemic myocardium and are increasingly recognized as critical regulators of inflammatory processes during myocardial ischemia and reperfusion (I/R). Platelets contain a broad repertoire of miRNAs, whic…
View article: Desipramine induces eryptosis in human erythrocytes, an effect blunted by nitric oxide donor sodium nitroprusside and N-acetyl-L-cysteine but enhanced by Calcium depletion
Desipramine induces eryptosis in human erythrocytes, an effect blunted by nitric oxide donor sodium nitroprusside and N-acetyl-L-cysteine but enhanced by Calcium depletion Open
Background: Desipramine a representative of tricyclic antidepressants (TCAs) promotes recovery of depressed patients by inhibition of reuptake of neurotransmitters serotonin (SER) and norepinephrine (NE) in the presynaptic membrane …
View article: Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease Open
Background Braak’s hypothesis states that sporadic Parkinson’s disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation …
View article: Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day
Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day Open
Background/Aims: Cells adapt to chronic extracellular hypotonicity by altering metabolism. Corresponding effects of sustained hypotonic exposure at the whole-person level remain to be confirmed and characterized in clinical and population-…
View article: Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia
Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia Open
Background: Platelets can infiltrate ischemic myocardium and are increasingly recognized as critical regulators of inflammatory processes during myocardial ischemia and reperfusion (I/R). Platelets contain a broad repertoire of microRNAs (…
View article: A Multi-Site Assessment of Anesthetic Overdose, Hypothermic Shock, and Electrical Stunning as Methods of Euthanasia for Zebrafish (Danio rerio) Embryos and Larvae
A Multi-Site Assessment of Anesthetic Overdose, Hypothermic Shock, and Electrical Stunning as Methods of Euthanasia for Zebrafish (Danio rerio) Embryos and Larvae Open
Euthanasia in zebrafish (Danio rerio) younger than 5 days post fertilization (dpf) is poorly described in the literature, and standardized protocols are lacking, most likely because larvae not capable of independent feeding are often not p…
View article: Fetal Tissue-Derived Mast Cells (MC) as Experimental Surrogate for In Vivo Connective Tissue MC
Fetal Tissue-Derived Mast Cells (MC) as Experimental Surrogate for In Vivo Connective Tissue MC Open
Bone-marrow-derived mast cells are matured from bone marrow cells in medium containing 20% fetal calf serum (FCS), interleukin (IL)-3 and stem-cell factor (SCF) and are used as in vitro models to study mast cells (MC) and their role in hea…
View article: Supplementary Material for: Requirement of Na+/H+ exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells
Supplementary Material for: Requirement of Na+/H+ exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells Open
Background/Aims: Vasopressin is a powerful stimulator of vascular calcification, augmenting osteogenic signaling in vascular smooth muscle cells (VSMCs) including up-regulation of the transcription factors core-binding factor α-1 (CBFA1), …
View article: Requirement of Na<sup>+</sup>/H<sup>+</sup> Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells
Requirement of Na<sup>+</sup>/H<sup>+</sup> Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells Open
Background/Aims: Vasopressin is a powerful stimulator of vascular calcification, augmenting osteogenic signaling in vascular smooth muscle cells (VSMCs) including upregulation of transcription factors such as core-binding fac…
View article: Zinc Ameliorates the Osteogenic Effects of High Glucose in Vascular Smooth Muscle Cells
Zinc Ameliorates the Osteogenic Effects of High Glucose in Vascular Smooth Muscle Cells Open
In diabetic patients, medial vascular calcification is common and associated with increased cardiovascular mortality. Excessive glucose concentrations can activate the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kB) …
View article: Carbonated wollastonite – An effective supplementary cementitious material?
Carbonated wollastonite – An effective supplementary cementitious material? Open
Carbonated wollastonite clinker (CS) may be suitable as supplementary cementitious material (SCM) for mortar and concrete. The microstructure of unground CS clinker, carbonated CS slurry and a mortar blended with carbonated CS are investig…
View article: Protective effects of spironolactone on vascular calcification in chronic kidney disease
Protective effects of spironolactone on vascular calcification in chronic kidney disease Open
These observations support a putative benefit of spironolactone treatment in CKD-associated vascular calcification. Further research is required to investigate possible improvements in cardiovascular outcomes by spironolactone and whether …
View article: Increased β-adrenergic stimulation augments vascular smooth muscle cell calcification via PKA/CREB signalling
Increased β-adrenergic stimulation augments vascular smooth muscle cell calcification via PKA/CREB signalling Open
View article: Oncologic Panendoscopy: Description of an Optimized Procedure Based on Our Experience
Oncologic Panendoscopy: Description of an Optimized Procedure Based on Our Experience Open
Introduction All patients with a new head and neck squamous cell carcinoma (HNSCC) undergo diagnostic panendoscopy as part of the screening for synchronous second primary tumors. It includes a pharyngolaryngoscopy (PLS), a tracheobronchosc…
View article: Comprehensive Profiling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson’s Disease
Comprehensive Profiling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson’s Disease Open
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. Accumulating evidence demonstrates that alpha-synuclein (α-Syn), an apparently predominant neuronal protein, is a major contributor to PD pathology. …
View article: Faster speed of onset of the depressive episode is associated with lower cytokine serum levels (IL-2, -4, -6, -10, TNF-α and IFN-γ) in patients with major depression
Faster speed of onset of the depressive episode is associated with lower cytokine serum levels (IL-2, -4, -6, -10, TNF-α and IFN-γ) in patients with major depression Open
View article: ANXA7 Regulates Platelet Lipid Metabolism and Ca <sup>2+</sup> Release in Arterial Thrombosis
ANXA7 Regulates Platelet Lipid Metabolism and Ca <sup>2+</sup> Release in Arterial Thrombosis Open
Rationale: Platelet activation after contact to subendothelial collagen leads to acute arterial thrombosis. ANXA7 (Annexin A7) is a phospholipid-binding protein participating in the regulation of intracellular Ca 2+ and exocytosis. Objecti…
View article: Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease
Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease Open
Chorea-acanthocytosis (ChAc) is a neurodegenerative disease caused by mutations in the VPS13A gene. It is characterized by several neurological symptoms and the appearance of acanthocytes. Elevated tyrosine kinase Lyn activity has been rec…