Jian Shen
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View article: Role of KLF2 and KLF3 in balancing recirculating and resident memory fates 2993
Role of KLF2 and KLF3 in balancing recirculating and resident memory fates 2993 Open
Description Differentiation of CD8 T cells from naïve to effector to memory cells is a crucial process for pathogen clearance and long-term protection. There are key transcription factors and trafficking molecules associated with this diff…
View article: The PBAF chromatin remodeling complex maintains progenitor quiescence and drives exhaustion to avert effector differentiation and prevent immunopathology during persistent infection 4587
The PBAF chromatin remodeling complex maintains progenitor quiescence and drives exhaustion to avert effector differentiation and prevent immunopathology during persistent infection 4587 Open
Description During chronic viral infection and cancer, CD8 T cells undergo a physiological adaptation known as T cell exhaustion. While most T cells in the exhausted pool are terminally differentiated, the Progenitor subset can self-renew,…
View article: Longitudinal single-cell lineage mapping of a tetramer-specific CD8+ T cell repertoire during an acute infection 4481
Longitudinal single-cell lineage mapping of a tetramer-specific CD8+ T cell repertoire during an acute infection 4481 Open
Description When a naïve CD8+ T cell encounters an epitope, it divides into clones with identical T cell receptors (TCRs). These clones expand during an effector phase to clear the virus, then contract before forming a stable memory popula…
View article: Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML
Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML Open
Introduction The molecular mechanisms underlying chronic myeloid leukemia (CML) progression from chronic phase (CP) to blast crisis (BC) remain incompletely understood. This study aimed to identify progression-specific genes and elucidate …
View article: Effects of fermented soybean meal on growth performance, antioxidant capacity and fecal microbiota of piglets
Effects of fermented soybean meal on growth performance, antioxidant capacity and fecal microbiota of piglets Open
Background Dry‐fermented soybean meal (DFSBM) and wet‐fermented soybean meal (WFSBM) were evaluated as alternatives to conventional soybean meal in piglet diets, focusing on growth performance, antioxidant function and fecal microbiome mod…
View article: Effects of Shunt Position on the Prognosis of Transjugular Intrahepatic Portosystemic Shunt in Patients With Cirrhotic Esophagogastric Variceal Bleeding
Effects of Shunt Position on the Prognosis of Transjugular Intrahepatic Portosystemic Shunt in Patients With Cirrhotic Esophagogastric Variceal Bleeding Open
Aims Post‐transjugular intrahepatic portosystemic shunt (TIPS) hepatic encephalopathy and stent dysfunction remain the principal clinical problems restricting the procedure's application. Establishing TIPS in the left branch of the portal …
View article: Most eligible candidates for primary tumor resection among metastatic colorectal cancer patients: a SEER-based population analysis
Most eligible candidates for primary tumor resection among metastatic colorectal cancer patients: a SEER-based population analysis Open
This study constructed and validated a predictive model to help clinicians identify patients with mCRC who are most likely to benefit from PTR.
View article: ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5 Open
Grass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China. It has been reported that the cytokine storm, resultin…
View article: The efficacy of transarterial chemoembolization combined with helical iodine-125 seed implant, lenvatinib and PD-1 inhibitors in patients with hepatocellular carcinoma complicated by main portal vein tumor thrombus: a retrospective study
The efficacy of transarterial chemoembolization combined with helical iodine-125 seed implant, lenvatinib and PD-1 inhibitors in patients with hepatocellular carcinoma complicated by main portal vein tumor thrombus: a retrospective study Open
Purpose To evaluate the efficacy and safety of a multimodal therapeutic approach involving transarterial chemoembolization (TACE) in conjunction with helical iodine-125 (I-125) seed implant, lenvatinib, and programmed cell death-1(PD-1) in…
View article: Development and Validation of a Prealbumin-Bilirubin Model for Prognostic Prediction in Intermediate Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Development and Validation of a Prealbumin-Bilirubin Model for Prognostic Prediction in Intermediate Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Open
Purpose To establish and validate a novel prognostic model to predict outcomes for intermediate hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Materials and Methods Clinical data from intermediat…
View article: A Retrospective Analysis: CCTA vs. TTE in Diagnosing Coronary Artery Fistula
A Retrospective Analysis: CCTA vs. TTE in Diagnosing Coronary Artery Fistula Open
Objective: This study aimed to compare and analyze the diagnostic performance of cardiac computed tomographic angiography (CCTA) and transthoracic echocardiography (TTE) for coronary artery fistula (CAF) and evaluate the effectiveness of t…
View article: Evaluation of the Efficacy and Safety of Transjugular Intrahepatic Portosystemic Shunt Combined With Concurrent Antegrade Embolization of Large Spontaneous Portosystemic Shunts
Evaluation of the Efficacy and Safety of Transjugular Intrahepatic Portosystemic Shunt Combined With Concurrent Antegrade Embolization of Large Spontaneous Portosystemic Shunts Open
Objectives To compare the long‐term efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) combined with concurrent antegrade embolization in treating portal hypertension with oesophagogastric variceal bleeding in pati…
View article: Maternal Iron Levels and Association With Gestational Diabetes: A Systematic Review and Meta‐Analysis
Maternal Iron Levels and Association With Gestational Diabetes: A Systematic Review and Meta‐Analysis Open
Background: This systematic review aimed to assess the association of iron level with gestational diabetes mellitus (GDM) risk. Methods: The relevant articles published between January 1, 1995 and January 17, 2023 were identified through a…
View article: Liver function dynamics in advanced hepatocellular carcinoma receiving immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization
Liver function dynamics in advanced hepatocellular carcinoma receiving immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization Open
Background: The efficacy and safety of transarterial chemoembolization (TACE) combined with immune checkpoint inhibitors (ICIs) and anti-vascular endothelial growth factor (anti-VEGF) antibody/tyrosine kinase inhibitors (TKIs) have been es…
View article: Immune Indicator Changes in Hepatocellular Carcinoma Undergoing TACE Plus ICIs and Anti-VEGF Antibodies/TKIs: A Prognostic Biomarker Analysis
Immune Indicator Changes in Hepatocellular Carcinoma Undergoing TACE Plus ICIs and Anti-VEGF Antibodies/TKIs: A Prognostic Biomarker Analysis Open
The combination therapy may modify the tumor microenvironment of HCC. Changing trends in circulating immune indicators and NLR can serve as potential biomarkers for predicting tumor response and guiding clinical treatment.
View article: Efficacy and Safety of Transarterial Chemoembolization Combined with PD-1 Inhibitors plus Molecular Targeted Therapies for Unresectable Hepatocellular Carcinoma with Child‒Pugh B
Efficacy and Safety of Transarterial Chemoembolization Combined with PD-1 Inhibitors plus Molecular Targeted Therapies for Unresectable Hepatocellular Carcinoma with Child‒Pugh B Open
Background and Objectives To assess the efficacy and safety of transarterial chemoembolization (TACE) combined with programmed cell death-1 (PD-1) inhibitors plus molecular targeted therapies (MTT) for unresectable hepatocellular carcinoma…
View article: Distribution of COVID-19 Home Testing Through Community Health Centers: Results of the <i>COVID CoNOce MÁS Study</i>
Distribution of COVID-19 Home Testing Through Community Health Centers: Results of the <i>COVID CoNOce MÁS Study</i> Open
Objective: To assess acceptability and feasibility of rapid at-home COVID-19 testing and reporting of test results among individuals seeking care at community health centers (CHCs) and their household members. Methods: Participants were re…
View article: Prognosis Prediction of CRAFITY Score in HCC Undergoing TACE Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapy
Prognosis Prediction of CRAFITY Score in HCC Undergoing TACE Combined with PD-(L)1 Inhibitors and Molecular Targeted Therapy Open
The CRAFITY score may provide an efficient predictive capacity for prognosis in HCC patients undergoing TACE combined with PD-(L)1 inhibitors and molecular targeted therapy.
View article: The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome
The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome Open
Animals living in high‐altitude environments, such as the Tibetan Plateau, must face harsh environmental conditions (e.g., hypoxia, cold, and strong UV radiation). These animals' physiological adaptations (e.g., increased red cell producti…
View article: Opening SCID Newborn Screening for novel exon genetic variants through whole-exome sequencing in China
Opening SCID Newborn Screening for novel exon genetic variants through whole-exome sequencing in China Open
Introduction: Severe combined immunodeficiency (SCID) is the most fatal form of inherited primary immunodeficiency disease. Known molecular defect mutations occur in most children with SCID. Design and Methods: We report ADA-genetically co…
View article: Transarterial chemoembolization combined with molecularly targeted agents plus immune checkpoint inhibitors for unresectable hepatocellular carcinoma: a retrospective cohort study
Transarterial chemoembolization combined with molecularly targeted agents plus immune checkpoint inhibitors for unresectable hepatocellular carcinoma: a retrospective cohort study Open
Purpose To retrospectively evaluate and compare treatment effectiveness and safety between transarterial chemoembolization (TACE) combined with molecularly targeted agents plus immune checkpoint inhibitors (TACE+T+I) and TACE combined with…
View article: Association of maternal dietary patterns derived by multiple approaches with gestational diabetes mellitus: a prospective cohort study
Association of maternal dietary patterns derived by multiple approaches with gestational diabetes mellitus: a prospective cohort study Open
We used two a priori diet scores [Mediterranean diet (aMed) and Diet Balance Index (DBI)] and two a posteriori approaches [principal components analysis (PCA) and reduced-rank regression (RRR)] to examine the association of maternal dietar…
View article: Combinatorial Polydopamine-Liposome Nanoformulation as an Effective Anti-Breast Cancer Therapy
Combinatorial Polydopamine-Liposome Nanoformulation as an Effective Anti-Breast Cancer Therapy Open
PDA@Lipo/DOX/ICG is a multifunctional nanoplatform based on PDA-coated liposomes for accurate and efficient combinatorial cancer therapy of chemotherapy and laser-induced PDT/PTT.
View article: Modified quantitative and volumetric response evaluation criteria for patients with hepatocellular carcinoma after transarterial chemoembolization
Modified quantitative and volumetric response evaluation criteria for patients with hepatocellular carcinoma after transarterial chemoembolization Open
Objective This study aimed to investigate the cutoff value of quantitative and volumetric response evaluation criteria for patients with hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) and compare the performanc…
View article: Transarterial Chemoembolization Combined with Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors versus Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Advanced Hepatocellular Carcinoma
Transarterial Chemoembolization Combined with Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors versus Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Advanced Hepatocellular Carcinoma Open
TACE combined with ICIs plus TKIs significantly improved OS, ORR, and DCR and showed a relatively longer PFS trend over ICIs combined with TKIs for advanced HCC.
View article: Transarterial Chemoembolization Combined With Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors for Unresectable Hepatocellular Carcinoma: Efficacy and Systemic Immune Response
Transarterial Chemoembolization Combined With Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors for Unresectable Hepatocellular Carcinoma: Efficacy and Systemic Immune Response Open
Background Locoregional therapy combined with systemic therapy can further improve the prognoses for HCC. However, the efficacy of TACE combined with ICIs and TKIs for HCC and whether this triple therapy can activate systemic immune respon…