Ling Zhong
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View article: Proteomic comparison of epidemic Australian <i>Bordetella pertussis</i> biofilm cells
Proteomic comparison of epidemic Australian <i>Bordetella pertussis</i> biofilm cells Open
Bordetella pertussis causes whooping cough, a severe respiratory infectious disease. Studies have compared the currently dominant single nucleotide polymorphism (SNP) cluster I (pertussis toxin promoter allele, ptxP3 ) and previously domin…
View article: WDR5 serves in co-activation and influences genome targeting of KLF3
WDR5 serves in co-activation and influences genome targeting of KLF3 Open
Krüppel-like factor 3 (KLF3) is a member of the archetypal SP/KLF family of transcription factors that bind GC-rich elements and CACCC boxes in promoters and enhancers via three classical zinc fingers (ZFs) at or near their C-termini. KLF3…
View article: Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model
Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model Open
Background Cystic fibrosis (CF) is caused by mutations in the CFTR gene, leading to epithelial dysfunction and progressive lung disease. Although CFTR modulators have transformed care, ∼10% of people with CF remain without effective therap…
View article: Correlation between death-coping self-efficacy and personality traits of intensive care unit nurses: a cross-sectional study
Correlation between death-coping self-efficacy and personality traits of intensive care unit nurses: a cross-sectional study Open
View article: Single-cell RNA sequencing and traditional RNA sequencing reveals the role of cancer-associated fibroblasts in head and neck squamous cell carcinomas cohort
Single-cell RNA sequencing and traditional RNA sequencing reveals the role of cancer-associated fibroblasts in head and neck squamous cell carcinomas cohort Open
Our study provides a novel CAF-based prognostic model and nomogram for predicting patient outcomes in HNSC. These findings highlight the importance of CAFs in the tumor microenvironment and their potential as therapeutic and prognostic bio…
View article: Deep Learning-Based Layout Analysis Method for Complex Layout Image Elements
Deep Learning-Based Layout Analysis Method for Complex Layout Image Elements Open
Layout analysis of elements is indispensable in graphic design, and layout design can make the audience receive visual information as well as more attractive. The combination of deep learning and graphic design has gradually turned into a …
View article: Single-cell RNA sequencing and traditional RNA sequencing reveals the role of Cancer-associated fibroblasts in Head and neck squamous cell carcinomas cohort
Single-cell RNA sequencing and traditional RNA sequencing reveals the role of Cancer-associated fibroblasts in Head and neck squamous cell carcinomas cohort Open
Background Head and neck squamous cell carcinomas (HNSCs) are among the most common tumors worldwide. Despite the availability of various diagnostic and therapeutic strategies, the incidence and mortality rates of HNSC remain high. Cancer-…
View article: Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications
Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications Open
The global prevalence of diabetes is rapidly increasing, significantly raising the risk of various cardiovascular diseases. Among these, diabetic cardiomyopathy (DCM) is a distinct and critical complication characterized by ventricular hyp…
View article: Identifying acute myeloid leukemia subtypes based on pathway enrichment
Identifying acute myeloid leukemia subtypes based on pathway enrichment Open
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and the second most common in children. Despite the introduction of targeted therapies, AML survival rates have shown limited improvement, particularly among …
View article: Enigmatic discoidal macrofossils with central ring from the Ediacaran Jiangchuan biota, Southwest China
Enigmatic discoidal macrofossils with central ring from the Ediacaran Jiangchuan biota, Southwest China Open
The Jiangchuan biota is a diverse macrofossil assemblage from the Jiucheng Member of the Dengying Formation, in the uppermost Ediacaran (Sinian) of Eastern Yunnan, Southwest China. This biota is well known for its macroalgal fossils preser…
View article: An SDS-PAGE Reverse-Phase Metaproteomics Approach For Polar Desert and Ornithogenic Soils
An SDS-PAGE Reverse-Phase Metaproteomics Approach For Polar Desert and Ornithogenic Soils Open
View article: Development and Application of a Meta-Proteomics Approach for Low Biomass Soils
Development and Application of a Meta-Proteomics Approach for Low Biomass Soils Open
View article: GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma Open
The metastasis or recurrence of rhabdomyosarcoma (RMS) is the primary cause of tumour-related deaths. Patients with high-risk RMS have poor prognosis with a 5-year overall survival rate of 20–30%. The lack of specific drug-targeted therapy…
View article: The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response
The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response Open
The cardiac KCNQ1 + KCNE1 (IKs) channel regulates heart rhythm under both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cyclic adenosine monophosphate (cAMP) level, leading to KCNQ1 pho…
View article: TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells Open
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISP…
View article: Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome Open
Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the…
View article: Identifying Causal Relations between Gut Microbiome, Metabolic Dysfunction-Associated Fatty Liver Disease and the Novel Mediators of Blood Metabolites
Identifying Causal Relations between Gut Microbiome, Metabolic Dysfunction-Associated Fatty Liver Disease and the Novel Mediators of Blood Metabolites Open
Background Research has established connection between gut microbiome and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD). However, the causal relationships and the roles of potential mediating factors, such as blo…
View article: The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response
The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response Open
The cardiac KCNQ1+KCNE1 (I Ks ) channel regulates heart rhythm in both normal and stress conditions. Under stress, the β-adrenergic stimulation elevates the intracellular cAMP level, leading to KCNQ1 phosphorylation by protein kinase A and…
View article: Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation
Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation Open
View article: Centralized industrialization of pork in Europe and America contributes to the global spread of Salmonella enterica
Centralized industrialization of pork in Europe and America contributes to the global spread of Salmonella enterica Open
View article: Proteomic comparison of epidemic Australian<i>Bordetella pertussis</i>biofilm cells
Proteomic comparison of epidemic Australian<i>Bordetella pertussis</i>biofilm cells Open
Bordetella pertussis causes whooping cough, a severe respiratory infectious disease. Studies have compared the currently dominant single nucleotide polymorphism (SNP) cluster I (pertussis toxin promoter allele, ptxP3 ) and previously domin…
View article: #389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice
#389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice Open
Background and Aims: Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to prevent chemotherapy induced infert…
View article: Functional coherence of the<i>Xist</i>and<i>RSX</i>protein interactomes: X chromosome inactivation in marsupials
Functional coherence of the<i>Xist</i>and<i>RSX</i>protein interactomes: X chromosome inactivation in marsupials Open
Long range epigenetic silencing is epitomised by X chromosome inactivation (XCI) in mammals. It is mediated by independently evolved, non-homologous long noncoding RNAs in eutherian and marsupial mammals ( XIST and RSX ). The Xist interact…
View article: Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain
Characterization of an archaeal virus-host system reveals massive genomic rearrangements in a laboratory strain Open
Halophilic archaea (haloarchaea) are known to exhibit multiple chromosomes, with one main chromosome and one or several smaller secondary chromosomes or megaplasmids. Halorubrum lacusprofundi , a model organism for studying cold adaptation…
View article: Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms
Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms Open
Pertussis, commonly known as whooping cough is a severe respiratory disease caused by the bacterium, Bordetella pertussis . Despite widespread vaccination, pertussis resurgence has been observed globally. The development of the current ace…
View article: G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex
G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex Open
G9a, also known as EHMT2, is essential for embryogenesis and has specific functions in multiple developmental processes. G9a inactivation affects development of the nervous system, which is formed with contribution of descendants of progen…
View article: Chinese herbal medicine for the treatment of cardiovascular diseases ─ Targeting cardiac ion channels
Chinese herbal medicine for the treatment of cardiovascular diseases ─ Targeting cardiac ion channels Open
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality, imposing an increasing global health burden. Cardiac ion channels (voltage-gated NaV, CaV, KVs, and others) synergistically…
View article: Data from Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in <i>CRLF2</i>-Rearranged Ph-like ALL
Data from Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in <i>CRLF2</i>-Rearranged Ph-like ALL Open
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is characterized by aberrant activation of signaling pathways and high risk of relapse. Approximately 50% of Ph-like ALL cases overexpress cytokine receptor-like factor 2 (CRLF2) as…
View article: Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia
Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia Open
Localized and chronic hypoxia of airway mucosa is a common feature of progressive respiratory diseases, including cystic fibrosis (CF). However, the impact of prolonged hypoxia on airway stem cell function and differentiated epithelium is …
View article: Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers
Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers Open
The cardiac KCNQ1 potassium channel carries the important I Ks current and controls the heart rhythm. Hundreds of mutations in KCNQ1 can cause life-threatening cardiac arrhythmia. Although KCNQ1 structures have been recently resolved, the …