Lanjing Wei
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View article: HuR inhibition overcomes cFLIP-mediated doxorubicin resistance in triple-negative breast cancer
HuR inhibition overcomes cFLIP-mediated doxorubicin resistance in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) presents therapeutic challenges due to limited targeted treatment options and resistance to chemotherapy drugs, such as doxorubicin. This study investigated doxorubicin resistance mechanisms and a strat…
View article: RNA-binding protein HuR inhibition induces multiple programmed cell death in breast and prostate cancer
RNA-binding protein HuR inhibition induces multiple programmed cell death in breast and prostate cancer Open
View article: Dual-Emission Fluorescence Resonance Energy Transfer (FRET) PCR Discriminates Salmonella Pullorum and Gallinarum
Dual-Emission Fluorescence Resonance Energy Transfer (FRET) PCR Discriminates Salmonella Pullorum and Gallinarum Open
Salmonella Pullorum (S. Pullorum) and Salmonella Gallinarum (S. Gallinarum) are two biovars of Salmonella enterica serovar Gallinarum, responsible for pullorum disease and fowl typhoid, which are the most prevalent and pathogenic forms of …
View article: A Retrospective Analysis of Salmonella Isolates across 11 Animal Species (1982–1999) Led to the First Identification of Chromosomally Encoded blaSCO-1 in the USA
A Retrospective Analysis of Salmonella Isolates across 11 Animal Species (1982–1999) Led to the First Identification of Chromosomally Encoded blaSCO-1 in the USA Open
Antimicrobial resistance (AMR) in non-typhoidal Salmonella is a pressing public health concern in the United States, necessitating continuous surveillance. We conducted a retrospective analysis of 251 Salmonella isolates from 11 animal spe…
View article: Exploring the Impact of Primer–Template Mismatches on PCR Performance of DNA Polymerases Varying in Proofreading Activity
Exploring the Impact of Primer–Template Mismatches on PCR Performance of DNA Polymerases Varying in Proofreading Activity Open
Polymerase chain reaction (PCR) is a widely used technique in gene expression analysis, diagnostics, and various molecular biology applications. However, the accuracy and sensitivity of PCR can be compromised by primer–template mismatches,…
View article: Functional inhibition of the <scp>RNA</scp>‐binding protein <scp>HuR</scp> sensitizes triple‐negative breast cancer to chemotherapy
Functional inhibition of the <span>RNA</span>‐binding protein <span>HuR</span> sensitizes triple‐negative breast cancer to chemotherapy Open
Chemotherapy remains the standard treatment for triple‐negative breast cancer (TNBC); however, chemoresistance compromises its efficacy. The RNA‐binding protein Hu antigen R (HuR) could be a potential therapeutic target to enhance the chem…
View article: Small Molecules Targeting the RNA-Binding Protein HuR Inhibit Tumor Growth in Xenografts
Small Molecules Targeting the RNA-Binding Protein HuR Inhibit Tumor Growth in Xenografts Open
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in several types of diseases, including cancer, making it a promising therapeutic target. We have identified small-molecule inhibitors of HuR through a…
View article: The clinical application value of gonadotropin-releasing hormone antagonist combined with low-dose HCG regimen in patients with ovarian hyper-stimulation based on clinical characteristics and laboratory indicators.
The clinical application value of gonadotropin-releasing hormone antagonist combined with low-dose HCG regimen in patients with ovarian hyper-stimulation based on clinical characteristics and laboratory indicators. Open
GnRH-A combined with low-dose HCG regimen is feasible for patients with ovarian hyper-response during IVF-ET/ICSI, and does not affect the implantation rate, clinical pregnancy rate, live birth rate, and early abortion rate of such patient…
View article: Functional Characterization of Multiple Ehrlichia chaffeensis Sodium (Cation)/Proton Antiporter Genes Involved in the Bacterial pH Homeostasis
Functional Characterization of Multiple Ehrlichia chaffeensis Sodium (Cation)/Proton Antiporter Genes Involved in the Bacterial pH Homeostasis Open
Ehrlichia chaffeensis causes human monocytic ehrlichiosis. Little is known about how this and other related tick-borne rickettsia pathogens maintain pH homeostasis in acidified phagosomes and the extracellular milieu. The membrane-bound so…
View article: Hydroxymethylbilane synthase (HMBS) gene-based endogenous internal control for avian species
Hydroxymethylbilane synthase (HMBS) gene-based endogenous internal control for avian species Open
With PCR becoming one of the most important and widely-used diagnostic tools for infectious diseases of poultry, an urgent need has developed for an endogenous internal control (EIC) that monitors the quality and quantity of poultry DNA in…
View article: Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis Open
View article: Monovalent cation/sodium: proton antiporter proteins of Ehrlichia chaffeensis
Monovalent cation/sodium: proton antiporter proteins of Ehrlichia chaffeensis Open
View article: A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis
A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis Open
View article: Identification and characterization of mcr mediated colistin resistance in extraintestinal Escherichia coli from poultry and livestock in China
Identification and characterization of mcr mediated colistin resistance in extraintestinal Escherichia coli from poultry and livestock in China Open
Antimicrobial resistance to colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of multidrug-resistant Enterobacteriaceae infection in humans. In this study, we investigat…
View article: Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China
Antimicrobial resistance in clinical Escherichia coli isolates from poultry and livestock, China Open
Poultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobi…
View article: Serological and molecular evidence of <i>Coxiella burnetii</i> in samples from humans and animals in China
Serological and molecular evidence of <i>Coxiella burnetii</i> in samples from humans and animals in China Open
The findings indicaten that C. burnetii is endemic in Yangzhou, China, and therefore human and animal health workers should be aware of the possibility of infections and the occurrence of outbreaks of Q fever.
View article: Development of a generic Ehrlichia FRET-qPCR and investigation of ehrlichioses in domestic ruminants on five Caribbean islands
Development of a generic Ehrlichia FRET-qPCR and investigation of ehrlichioses in domestic ruminants on five Caribbean islands Open
In a single reaction, our Ehrlichia FRET-qPCR can detect the Ehrlichia spp. we studied and differentiate them into four groups. Domestic ruminants in the Caribbean are not uncommonly exposed to Ehrlichia, possibly E. canis or very closely …
View article: Molecular detection of vector-borne agents in dogs from ten provinces of China
Molecular detection of vector-borne agents in dogs from ten provinces of China Open
Our study confirms that B. vogeli, B. gibsoni, H. canis, and E. canis occur in China. Also, we present evidence that T. orientalis or a closely related organism can infect dogs.
View article: First report of Rickettsia felisin China
First report of Rickettsia felisin China Open
View article: First report of Babesia gibsoni in Central America and survey for vector-borne infections in dogs from Nicaragua
First report of Babesia gibsoni in Central America and survey for vector-borne infections in dogs from Nicaragua Open
View article: Detection of Salmonella spp. Using a Generic and Differential FRET-PCR
Detection of Salmonella spp. Using a Generic and Differential FRET-PCR Open
To facilitate the detection of Salmonella and to be able to rapidly and conveniently determine the species/subspecies present, we developed and tested a generic and differential FRET-PCR targeting their tetrathionate reductase response reg…