Lanlan Han
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View article: Functional Characterization of Fp2Cas9, a Cold-Adapted Type II-C CRISPR Nuclease from Flavobacterium psychrophilum
Functional Characterization of Fp2Cas9, a Cold-Adapted Type II-C CRISPR Nuclease from Flavobacterium psychrophilum Open
Cas9 with specialized temperature adaptations are essential for broadening the application of CRISPR-based genome editing across diverse biological contexts. Although Cas9 orthologs from thermophilic and mesophilic organisms have been char…
View article: Unveiling the neglected role of oxygen doping in nitrogen-doped carbon for enhanced capacitive deionization performance
Unveiling the neglected role of oxygen doping in nitrogen-doped carbon for enhanced capacitive deionization performance Open
Nitrogen-doped carbons (NCs) have demonstrated notable advantages for application in capacitive deionization (CDI). However, the potential roles of different nitrogen configurations in the CDI process, especially how the neglected oxygen d…
View article: Enhanced redox kinetics of Prussian blue analogues for superior electrochemical deionization performance
Enhanced redox kinetics of Prussian blue analogues for superior electrochemical deionization performance Open
The Mn substitution and structure optimization via ppy connection confer enhanced ion/electron migration to NiHCF. This results in rapid redox kinetics, improves electrode integrity, and ultimately ensures high desalination performance.
View article: RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization
RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization Open
To survive diverse host environments, the human pathogen Streptococcus pneumoniae must prevent its self-produced, extremely high levels of peroxide from reacting with intracellular iron. However, the regulatory mechanism(s) by which the pn…
View article: <i>Streptomyces wadayamensis</i> MppP is a PLP-Dependent Oxidase, Not an Oxygenase
<i>Streptomyces wadayamensis</i> MppP is a PLP-Dependent Oxidase, Not an Oxygenase Open
The PLP-dependent l-arginine hydroxylase/deaminase MppP from Streptomyces wadayamensis (SwMppP) is involved in the biosynthesis of l-enduracididine, a nonproteinogenic amino acid found in several nonribosomally produced peptide antibiotics…
View article: Swit_4259, an acetoacetate decarboxylase-like enzyme from <i>Sphingomonas wittichii</i> RW1
Swit_4259, an acetoacetate decarboxylase-like enzyme from <i>Sphingomonas wittichii</i> RW1 Open
The Gram-negative bacterium Sphingomonas wittichii RW1 is notable for its ability to metabolize a variety of aromatic hydrocarbons. Not surprisingly, the S. wittichii genome contains a number of putative aromatic hydrocarbon-degrading gene…
View article: Periplasmic Cytophaga hutchinsonii Endoglucanases Are Required for Use of Crystalline Cellulose as the Sole Source of Carbon and Energy
Periplasmic Cytophaga hutchinsonii Endoglucanases Are Required for Use of Crystalline Cellulose as the Sole Source of Carbon and Energy Open
The soil bacterium Cytophaga hutchinsonii actively digests crystalline cellulose by a poorly understood mechanism. Genome analyses identified nine genes predicted to encode endoglucanases with roles in this process. No predicted cellobiohy…
View article: Phylogenetic tree of the HSP70 and HSC70 sequences, constructed using the neighbor-joining method.
Phylogenetic tree of the HSP70 and HSC70 sequences, constructed using the neighbor-joining method. Open
A three-letter code has been included to indicate the order name of the corresponding insects and vertebrates (COL = Coleoptera, LEP = Lepidoptera, DIP = Diptera, HYM = Hymenoptera and VER = Vertebra). The values indicated on the branches …
View article: <i>Streptomyces wadayamensis</i> MppP Is a Pyridoxal 5′-Phosphate-Dependent <scp>l</scp>-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway
<i>Streptomyces wadayamensis</i> MppP Is a Pyridoxal 5′-Phosphate-Dependent <span>l</span>-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway Open
L-Enduracididine (L-End) is a nonproteinogenic amino acid found in a number of bioactive peptides, including the antibiotics teixobactin, enduracidin, and mannopeptimycin. The potent activity of these compounds against antibiotic-resistant…
View article: Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Open
3-Indolylmethanamines represent a new class of antitumor agents. We have shown for the first time the in vivo anticancer effects of 3-indolylmethanamines 31B and PS121912.
View article: The Aspartate-Less Receiver (ALR) Domains: Distribution, Structure and Function
The Aspartate-Less Receiver (ALR) Domains: Distribution, Structure and Function Open
Two-component signaling systems are ubiquitous in bacteria, Archaea and plants and play important roles in sensing and responding to environmental stimuli. To propagate a signaling response the typical system employs a sensory histidine ki…