Lan Huang
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View article: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief Open
Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules bridging a protein with an E3 ubiquitin ligase, promoting its ubiquitylation and degradation. However, PROTACs are not without limitations, including suboptimal target deg…
View article: Emerging resistance in genital mycoplasmas: 6-year trends of Ureaplasma spp. and Mycoplasma hominis infections in Eastern China
Emerging resistance in genital mycoplasmas: 6-year trends of Ureaplasma spp. and Mycoplasma hominis infections in Eastern China Open
Not applicable.
View article: Layer-Aware Influence for Online Data Valuation Estimation
Layer-Aware Influence for Online Data Valuation Estimation Open
Data-centric learning emphasizes curating high-quality training samples to boost performance rather than designing new architectures. A central problem is to estimate the influence of training sample efficiently. Prior studies largely focu…
View article: Limited genomic diversity and convergent adaptation of Brucella melitensis isolated from human in East China, from 2011 to 2024
Limited genomic diversity and convergent adaptation of Brucella melitensis isolated from human in East China, from 2011 to 2024 Open
Objective This study aimed to investigate the genomic epidemiology of Brucella melitensis in Jiangsu Province, a typical low-endemic region in East China where the incidence of human brucellosis has been increasing in recent years. Accordi…
View article: Mechanisms Of S-Palmitoylation Inhibition Reshapes Calcium Homeostasis In Periodontitis
Mechanisms Of S-Palmitoylation Inhibition Reshapes Calcium Homeostasis In Periodontitis Open
Aim or purpose: This study investigates whether inhibiting ZDHHC6-mediated S-palmitoylation of calcium transporters rescues ER-mitochondrial dysfunction in chronic periodontitis, thereby restoring immuno-osseous homeostasis Materials and m…
View article: Pressure optimization control of low-pressure vacuum systems based on anti-disturbance Smith predictor compensation
Pressure optimization control of low-pressure vacuum systems based on anti-disturbance Smith predictor compensation Open
In addressing the challenges posed by significant time delays and multiple disturbances in low-pressure vacuum systems, this paper proposes an anti-disturbance Smith predictor compensation control method. The method, based on the dynamic c…
View article: Phylogenetic evidence for nationwide expansion Brucella melitensis lineages drives the re-emerging and epidemic of human brucellosis in Jiangsu, China
Phylogenetic evidence for nationwide expansion Brucella melitensis lineages drives the re-emerging and epidemic of human brucellosis in Jiangsu, China Open
Objective Human brucellosis has re-emerged as a major public health threat in Jiangsu Province, but the sources and transmission dynamics of circulating strains remain poorly understood. Methods In this study, we integrated conventional bi…
View article: Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications
Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications Open
Natural killer (NK) cells are pivotal effectors in innate antitumor immunity by mediating cytotoxicity, secreting cytokines, or expressing cell membrane receptors, which facilitate interactions with other immune cells. The cytotoxic activi…
View article: An Update of Immunohistochemistry in Hepatocellular Carcinoma
An Update of Immunohistochemistry in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) remains a global health challenge due to molecular heterogeneity and frequent delayed diagnosis. This comprehensive review synthesizes recent immunohistochemistry (IHC) advancements for HCC diagnosis, prognos…
View article: Mapping Dissolved Organic Carbon and Identifying Drivers in Chaohu Lake: A Novel Convolutional Multi-Head Attention Fusion Network with Hyperspectral Data
Mapping Dissolved Organic Carbon and Identifying Drivers in Chaohu Lake: A Novel Convolutional Multi-Head Attention Fusion Network with Hyperspectral Data Open
Dissolved organic carbon (DOC) maintains the ecological balance of inland lake systems and contributes significantly to the global carbon cycle. This study aims to develop a novel deep learning algorithm to predict DOC concentrations and e…
View article: Pressure control method for low-pressure vacuum systems based on mismatch-resistant Smith predictor compensation
Pressure control method for low-pressure vacuum systems based on mismatch-resistant Smith predictor compensation Open
To achieve efficient and high-precision pressure control for low-pressure vacuum systems, a pressure control method based on mismatch-resistant Smith Predictor (SP) compensation is proposed. First, a control scheme consisting of an SP and …
View article: Batch evaluation of collective owned commercialised construction land using machine learning
Batch evaluation of collective owned commercialised construction land using machine learning Open
The market entry of collective owned commercialised construction land (CCCL) is a crucial element of China's ongoing rural land system reform. However, traditional appraisal methods struggle with efficiency and accuracy in the context of b…
View article: Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker
Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker Open
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy predominantly managed via chemotherapy. Our clinical sample analysis revealed a significant correlation between elevated CD24 expression in TNBC tumor cells and …
View article: Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities
Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities Open
Breast cancer (BC) has the highest prevalence among cancers specific to women, and its incidence rates are increasing in many countries. Subtypes of BC, including HER2-positive or triple-negative BC, exhibit differing treatment responses; …
View article: Boric acid modification enabled efficient phosphate removal with crayfish shell biochar via calcium coprecipitation
Boric acid modification enabled efficient phosphate removal with crayfish shell biochar via calcium coprecipitation Open
Although it has been demonstrated that biochar is an efficient technique for alleviating phosphate pollution in water, its widespread application has been limited due to the low adsorption capacity of raw biochar. Given calcium's high affi…
View article: Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia
Aberrant static and dynamic functional connectivity of insular cortex in patients with trigeminal neuralgia Open
The abnormal insular-related static and dynamic functional connectivity (sFC and dFC) in patients with trigeminal neuralgia (TN) is not well understood. Therefore, we aimed to explore alterations in the sFC and dFC of the insular cortex(IC…
View article: Batch Evaluation of Collective Owned Commercialized Construction Land Using Machine Learning
Batch Evaluation of Collective Owned Commercialized Construction Land Using Machine Learning Open
The market entry of collective owned commercialized construction land (CCCL) is a pivotal element of China's ongoing rural land system reform. Traditional appraisal methods, however, struggle with efficiency and accuracy in the context of …
View article: The non-linear relationship between the visceral adiposity index and the risk of prediabetes and diabetes
The non-linear relationship between the visceral adiposity index and the risk of prediabetes and diabetes Open
Background The visceral adiposity index is a valuable tool for assessing visceral fat accumulation. However, its non-linear association with prediabetes and diabetes requires further elucidation. Therefore, we aim to clarify the intricate …
View article: Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients
Multiplex immunohistochemistry reveals histological features of three different intestinal polyp subtypes in pediatric patients Open
These findings not only deepen our structural understanding of various intestinal polyp subtypes but also offer valuable insights that may inform the diagnosis of patients with these conditions.
View article: China Anti-Cancer Association (CACA) guidelines for treating cancer-related malnutrition
China Anti-Cancer Association (CACA) guidelines for treating cancer-related malnutrition Open
Malnutrition in cancer patients is the result of a variety of factors. Decreased intake, absorption disorders, metabolic disorders and increased REE are the main causes of malnutrition. The incidence of malnutrition in cancer patients is h…
View article: Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway
Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway Open
Objective Mitochondrial metabolic reprogramming in macrophages is crucial in the development and progression of inflammation. Given vitamin A’s antioxidant properties and its therapeutic effects on inflammation, this study aims to elucidat…
View article: <i>Staphylococcus aureus nt5</i> gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion
<i>Staphylococcus aureus nt5</i> gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion Open
The resistance of commonly used clinical antibiotics, such as daptomycin (DAP), has become increasingly serious in the fight against Staphylococcus aureus (S. aureus) infection. It is essential to explore key pathogenicity-dr…
View article: Long-term smoking contributes to aging frailty and inflammatory response
Long-term smoking contributes to aging frailty and inflammatory response Open
In recent years, the health challenges linked to frailty in the elderly, particularly those worsened by cigarette smoke, have become more pronounced. However, quantitative studies examining the impact of smoking dosage on frailty in this p…
View article: Assessment of a Hyperspectral Remote Sensing Model Performance for Particulate Phosphorus in Optically Shallow Lake Water
Assessment of a Hyperspectral Remote Sensing Model Performance for Particulate Phosphorus in Optically Shallow Lake Water Open
Particulate phosphorus (PP) is a major contributor to lakes developing eutrophic. It also serves as one of the most significant sources of phosphorus for primary productivity, serving as a possible source of soluble reactive phosphorus, an…
View article: Crosslinking-Mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2&nbsp;<span>in Regulating Protein Neddylation</span>
Crosslinking-Mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 <span>in Regulating Protein Neddylation</span> Open
View article: Digital and Smart Assembly of Laser Target Designation Based on Digital Twin
Digital and Smart Assembly of Laser Target Designation Based on Digital Twin Open
To solve the problems of low production efficiency and poor quality consistency in the assembly of laser target designation (ALTD), a digital and smart assembly method of laser target designation based on digital twin was proposed. Through…
View article: The association between sodium–glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: a propensity-matched study
The association between sodium–glucose cotransporter 2 inhibitors and contrast-associated acute kidney injury in patients with type 2 diabetes undergoing angiography: a propensity-matched study Open
View article: Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation
Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation Open
Prolyl Hydroxylase Domain protein 2 (PHD2) targets Hypoxia Inducible Factor alpha subunits (HIFα) for oxygen-dependent proline hydroxylation that leads to subsequent ubiquitination and degradation of HIFα. In addition to HIF proteins, grow…
View article: Spatio-temporal analysis of agroforestry systems in hotan using multi-source remote sensing and deep learning
Spatio-temporal analysis of agroforestry systems in hotan using multi-source remote sensing and deep learning Open
In the Hotan region of Xinjiang, where arable land is scarce, an agroforestry system integrating walnut trees with crops has been implemented to maximize land-use efficiency. While this dense planting enhances land use, it also limits the …
View article: Machine learning-based analysis identifies a 13-gene prognostic signature to improve the clinical outcomes of colorectal cancer
Machine learning-based analysis identifies a 13-gene prognostic signature to improve the clinical outcomes of colorectal cancer Open
The 13-gene prognostic signature is expected to be a valuable tool for risk stratification, survival prediction, and treatment evaluation of patients with CRC.