Lantao Gu
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View article: Single-cell transcriptomics reveals the mechanisms of lung injury induced by galt gene editing in mouse
Single-cell transcriptomics reveals the mechanisms of lung injury induced by galt gene editing in mouse Open
Galactosemia, caused by mutations in the GALT gene, leads to multi-organ damage. This study investigates the impact of Galt c.847 + 1G > T mutation on lung tissue using single-cell transcriptomics. We employed CRISPR/Cas9 to generate a Gal…
View article: Elucidating Phosphate and Cadmium Cosorption Mechanisms on Mineral Surfaces with Direct Spectroscopic and Modeling Evidence
Elucidating Phosphate and Cadmium Cosorption Mechanisms on Mineral Surfaces with Direct Spectroscopic and Modeling Evidence Open
The simultaneous sorption of cations and anions at the mineral-water interface can substantially alter their individual sorption characteristics; however, this phenomenon lacks a mechanistic understanding. Our study provides direct spectro…
View article: Epidemiological Study and Physiological Analysis of Snakebite Envenoming in China Northern Guangxi Zhuang Autonomous Region-a Retrospective Study
Epidemiological Study and Physiological Analysis of Snakebite Envenoming in China Northern Guangxi Zhuang Autonomous Region-a Retrospective Study Open
Background Snakebite causing huge social costs worldwide. However, no systematic report of snake injuries in China Northern Guangxi Zhuang Autonomous Region until now. In this study, the details of patients with snake bites were retrospect…
View article: Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds Open
Background Repairation of bone defects remains a major clinical problem. Constructing bone tissue engineering containing growth factors, stem cells, and material scaffolds to repair bone defects has recently become a hot research topic. Ne…
View article: Investigating the genetic determination of duration-of-fertility trait in breeding hens
Investigating the genetic determination of duration-of-fertility trait in breeding hens Open
The duration-of-fertility (DF), which was defined as the number of days when breeding hens lay fertile eggs following copulation or artificial insemination (AI), is an important economic trait in chick production when it has strong effects…
View article: Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds
Acceleration of bone repairation by BMSCs overexpressing NGF combined with NSA and allograft bone scaffolds Open
Background Repairation of bone defects remains a major clinical problem. Constructing bone tissue engineering containing growth factors, stem cells, and material scaffolds to repair bone defects has recently become a hot research topic. Ne…
View article: Transcriptome sequencing revealed that knocking down FOXL2 affected cell proliferation, the cell cycle, and DNA replication in chicken pre-ovulatory follicle cells
Transcriptome sequencing revealed that knocking down FOXL2 affected cell proliferation, the cell cycle, and DNA replication in chicken pre-ovulatory follicle cells Open
Forkhead box L2 (FOXL2) is a single-exon gene encoding a forkhead transcription factor, which is mainly expressed in the ovary, eyelids and the pituitary gland. FOXL2 plays an essential role in ovarian development. To reveal the effects of…
View article: Identifying artificial selection signals in the chicken genome
Identifying artificial selection signals in the chicken genome Open
Identifying the signals of artificial selection can contribute to further shaping economically important traits. Here, a chicken 600k SNP-array was employed to detect the signals of artificial selection using 331 individuals from 9 breeds,…
View article: Novel copy number variation of the TGFβ3 gene is associated with TGFβ3 gene expression and duration of fertility traits in hens
Novel copy number variation of the TGFβ3 gene is associated with TGFβ3 gene expression and duration of fertility traits in hens Open
Improvements in the duration of fertility (DF) could increase the interval between successive artificial inseminations, thereby decreasing the cost associated with production of hatching eggs. The molecular mechanisms involved in DF in hen…