Lanxia Meng
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View article: The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson’s disease
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson’s disease Open
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the death of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies that are composed of aggregated α-synuclein (α-Syn). However, the factors t…
View article: Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner (Adv. Sci. 7/2025)
Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner (Adv. Sci. 7/2025) Open
Parkinson's Disease In article number 2413451, Zhentao Zhang and co‐workers show that microglia process α‐synuclein fibrils to generate novel fibrils with enhanced toxicity, promoting the onset and progression of Parkinson's disease. α‐Syn…
View article: Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner
Microglia Process α‐Synuclein Fibrils and Enhance their Pathogenicity in a TREM2‐Dependent Manner Open
Parkinson's disease (PD) is characterized by the deposition of misfolded α‐synuclein (α‐syn) in the brain. Converging evidence indicates that the intracellular transmission and subsequent templated amplification of α‐syn are involved in th…
View article: PM2.5 triggers tau aggregation in a mouse model of tauopathy
PM2.5 triggers tau aggregation in a mouse model of tauopathy Open
The aggregation and prion-like propagation of tau are the hallmarks of Alzheimer's disease (AD) and other tauopathies. However, the molecular mechanisms underlying the assembly and spread of tau pathology remain elusive. Epidemiological da…
View article: Physiological and pathological functions of TMEM106B in neurodegenerative diseases
Physiological and pathological functions of TMEM106B in neurodegenerative diseases Open
As an integral lysosomal transmembrane protein, transmembrane protein 106B (TMEM106B) regulates several aspects of lysosomal function and is associated with neurodegenerative diseases. The TMEM106B gene mutations lead to lysosomal dysfunct…
View article: Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice
Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice Open
The bridging integrator 1 (BIN1) gene is an important risk locus for late-onset Alzheimer’s disease (AD). BIN1 protein has been reported to mediate tau pathology, but the underlying molecular mechanisms remain elusive. Here, we show that n…
View article: The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease
The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease Open
Parkinson’s disease (PD) is characterized by the pathologic aggregation and prion-like propagation of α-synuclein (α-syn). Emerging evidence shows that fungal infections increase the incidence of PD. However, the molecular mechanisms by wh…
View article: The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy
The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy Open
The molecular mechanisms that trigger Tau aggregation in Alzheimer's disease (AD) remain elusive. Fungi, especially Saccharomyces cerevisiae (S. cerevisiae), can be found in brain samples from patients with AD. Here, we show that the yeast…
View article: <scp>α‐Synuclein</scp> induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression
<span>α‐Synuclein</span> induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression Open
Parkinson's disease (PD) is an age‐related chronic neurological disorder, mainly characterized by the pathological feature of α‐synuclein (α‐syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of…
View article: The γ-Adducin 1–357 fragment promotes tau pathology
The γ-Adducin 1–357 fragment promotes tau pathology Open
Background Tau phosphorylation is a pathological hallmark of Alzheimer’s disease (AD). Previously, we reported that the γ-adducin 1–357 fragment is present in the brains of AD patients. However, it remains unknown how γ-adducin regulates t…
View article: Pathogen infection in Alzheimer’s disease: pathophysiology and therapeutic strategies
Pathogen infection in Alzheimer’s disease: pathophysiology and therapeutic strategies Open
Alzheimer’s disease (AD) is the most common neurodegenerative disease, which is characterized by the deposition of senile plaques composed of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Currently,…
View article: Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms
Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms Open
Maneb, a widely-used dithiocarbamate fungicide, remains in the environment and exerts adverse health effects. Epidemiological evidence shows that maneb exposure is associated with a higher risk of Parkinson's disease (PD), one of the most …
View article: N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity
N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity Open
The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is associated with an increased risk of PD. However, the molecula…
View article: Role of defensins in diabetic wound healing
Role of defensins in diabetic wound healing Open
The adverse consequences resulting from diabetes are often presented as severe complications. Diabetic wounds are one of the most commonly occurring complications in diabetes, and the control and treatment of this is costly. Due to a serie…
View article: Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial Peptide
Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial Peptide Open
Scorpion peptides have good therapeutic effect on chronic ulcer of diabetic foot, but the related pharmacological mechanism has remained unclear. The different proteins and bacteria present in ulcer exudates from chronic diabetic foot pati…
View article: α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression
α-Synuclein induces deficiency in clathrin-mediated endocytosis through inhibiting synaptojanin1 expression Open
Background Parkinson’s disease (PD) is mainly characterized by the pathological feature of α-synuclein (α-syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of PD, synaptic dysfunction including…
View article: 7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1–103 transgenic mice
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1–103 transgenic mice Open
Parkinson's disease (PD) is the most common motor-associated neurodegenerative disease. Although the pathogenesis of PD is still wrapped in the mist, accumulating evidence indicates that mitochondrial dysfunction contributes to the onset a…
View article: A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease Open
Synaptic dysfunction is a key feature of Alzheimer's disease (AD). However, the molecular mechanisms underlying synaptic dysfunction remain unclear. Here, we show that synapsin Ⅰ, one of the most important synaptic proteins, is fragmented …
View article: Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease Open
Background The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The incidence of AD is increas…
View article: Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology Open
Silica nanoparticles (SiO 2 NPs) are increasingly investigated for their potential in drug delivery systems. However, the neurotoxicity of SiO 2 NPs remains to be fully clarified. Previously SiO 2 NPs have been reported to be detected in t…
View article: Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson’s Disease
Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson’s Disease Open
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. However, its cellular and molecular mechanisms still wrap in the mist. This is partially caused by the absence of appropriate animal models mimicking sporadic …
View article: Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction Open
Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer’s disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I …