Lanxiao Cao
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View article: LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma
LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma Open
Tumor angiogenesis plays a crucial role in the progression of hepatocellular carcinoma (HCC), serving as a key process for metastasis and invasion. Leucine-rich repeat-containing 1 (LRRC1) has been reported to be abnormally upregulated in …
View article: A novel chronic hepatitis B mouse model with immune activation and liver fibrosis
A novel chronic hepatitis B mouse model with immune activation and liver fibrosis Open
As one of the key features of the immune active (IA) phase (HBeAg-positive) in chronic hepatitis B (CHB), liver fibrosis (LF) is a critical treatable stage to avoid progressing to hepatocellular carcinoma (HCC). There is an urgent need to …
View article: A Novel HBV-Related Hepatic Fibrosis Modeling Via Both Enhancing the Immune Tolerance and Inducing Alternate Immune (Re)Activation in PAAV-HBV1.2 Mice by Porcine Serum Injection
A Novel HBV-Related Hepatic Fibrosis Modeling Via Both Enhancing the Immune Tolerance and Inducing Alternate Immune (Re)Activation in PAAV-HBV1.2 Mice by Porcine Serum Injection Open
View article: Analysis of common genetic variation of anxiety disorders in essential tremor
Analysis of common genetic variation of anxiety disorders in essential tremor Open
Objective To explore the association of common genetic variation of anxiety disorders and essential tremor (ET). Methods We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 505 age and gender-matched…
View article: Two novel GFAP mutations and genotype-phenotype associations in Alexander disease
Two novel GFAP mutations and genotype-phenotype associations in Alexander disease Open
Background Alexander disease (AxD) is a rare genetic disorder caused by mutations in the GFAP gene, which encodes glial fibrillary acidic protein and leads to astrocyte dysfunction. This study aims to report two novel GFAP mutations in Chi…
View article: Spinocerebellar ataxia type 8 presents as progressive supranuclear palsy
Spinocerebellar ataxia type 8 presents as progressive supranuclear palsy Open
Spinocerebellar ataxia type 8 is a progressive neurodegenerative disease induced by expansion of CTA/CTG repeats in an untranslated region of the ATXN8/ATXN8OS gene. We report an elderly female patient presenting with rigidity, brad…
View article: Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China
Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China Open
Background Essential tremor (ET) is a neurological disease characterized by action tremor in upper arms. Although its high heritability and prevalence worldwide, its etiology and association with other diseases are still unknown. Method We…
View article: Association analysis of 27 single-nucleotide polymorphisms in a Chinese population with essential tremor
Association analysis of 27 single-nucleotide polymorphisms in a Chinese population with essential tremor Open
Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET associated genes in a relatively large Chinese population cohort. We genotyped 27 single-nucleotide polymorphisms (SNP…
View article: Burden of Parkinson Disease in China, 1990–2019: Findings from the 2019 Global Burden of Disease Study
Burden of Parkinson Disease in China, 1990–2019: Findings from the 2019 Global Burden of Disease Study Open
Introduction: China has the most people with Parkinson disease (PD) in the world and is estimated to have over half of the worldwide PD population. The objective of this study was to analyze the corresponding burden of PD in China for the …
View article: Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease
Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease Open
Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein …
View article: Concomitant Othello syndrome and impulse control disorders in a patient with Parkinson’s disease: A case report
Concomitant Othello syndrome and impulse control disorders in a patient with Parkinson’s disease: A case report Open
Given its potential for severe consequences, OS should be identified early, especially in patients undergoing treatment with dopamine agonists.
View article: Autosomal dominant sleep-related hypermotor epilepsy associated with a novel mutation of <i>KCNT1</i>
Autosomal dominant sleep-related hypermotor epilepsy associated with a novel mutation of <i>KCNT1</i> Open
Autosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by severe sleep-related rigid hypermotor seizures. The pathogenic genes of ADSHE include genes encoding subunits of the neuronal nicotinic acetylcholine receptor…
View article: Validation of the Chinese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease
Validation of the Chinese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Open
Background: Impulse control and related disorders (ICRDs) have gained recognition as a severe complication of Parkinson's disease (PD) and are connected to poor quality of life and devastating financial and social problems. This study aime…
View article: Compound heterozygous mutations in the neuraminidase 1 gene in type 1 sialidosis: A case report and review of literature
Compound heterozygous mutations in the neuraminidase 1 gene in type 1 sialidosis: A case report and review of literature Open
Through retrospective analysis and summarizing the clinical and genetic characteristics of type 1 sialidosis, we hope to raise awareness of lysosomal storage disorders among clinicians and minimize the delay in diagnosis.
View article: Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review
Chinese patient with cerebrotendinous xanthomatosis confirmed by genetic testing: A case report and literature review Open
CYP27A1 genetic analysis should be the definitive method for CTX diagnosis. This case suggests that urinary system diseases may be neglected in CTX patients. The clinical, biological, radiological, and genetic characteristics of CTX…
View article: Assessing the <i>NOTCH2NLC</i> GGC expansion in essential tremor patients from eastern China
Assessing the <i>NOTCH2NLC</i> GGC expansion in essential tremor patients from eastern China Open