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View article: P1239: BRUTON TYROSINE KINASE (BTK) PROTEIN DEGRADER BGB-16673 IS LESS APT TO CAUSE, AND ABLE TO OVERCOME VARIABLE BTK RESISTANCE MUTATIONS COMPARED TO OTHER BTK INHIBITORS (BTKI)
P1239: BRUTON TYROSINE KINASE (BTK) PROTEIN DEGRADER BGB-16673 IS LESS APT TO CAUSE, AND ABLE TO OVERCOME VARIABLE BTK RESISTANCE MUTATIONS COMPARED TO OTHER BTK INHIBITORS (BTKI) Open
Topic: 20. Lymphoma Biology & Translational Research Background: BTK plays a critical role in the B-cell antigen receptor signaling pathway and the pathogenesis of multiple B-cell malignancies. Covalent, irreversible BTKi have been instrum…
View article: Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells Open
The protein C receptor (Procr) has been implicated as a stem cell surface marker in several tissues. It is unknown whether Procr acts as a functional signaling receptor in stem cells. Here, by conditional knockout in mammary stem cells (Ma…
View article: Author response: Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
Author response: Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Ovarian sur…
View article: Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair
Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair Open
Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and OSE stem cells rapidly generate new cells for the repair. How the stem cell senses the rupture and promptly turns on proliferation is unclear. Our previous study ha…
View article: Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors Open
View article: Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course Open
The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, an…