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View article: Association of non-traditional lipid indices with diabetes and insulin resistance in US adults: mediating effects of HOMA-IR and evidence from a national cohort
Association of non-traditional lipid indices with diabetes and insulin resistance in US adults: mediating effects of HOMA-IR and evidence from a national cohort Open
Dyslipidemia, diabetes mellitus, and insulin resistance (IR) are intricately linked. In recent years, a series of novel lipid indices have emerged. Investigating their correlation with diabetes and IR is critical for early intervention. Th…
View article: A phase I study of MEDI1873, a novel GITR agonist, in advanced solid tumors
A phase I study of MEDI1873, a novel GITR agonist, in advanced solid tumors Open
Background: MEDI1873 is a novel GITR-ligand/IgG1 agonist fusion protein that binds the co-stimulatory glucocorticoid-induced TNF receptor family-related protein (GITR) on CD4+ and CD8+ effector T cells and regulatory T cells. This Phase 1 …