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View article: BMP4-Induced Suppression of Breast Cancer Metastasis Is Associated with Inhibition of Cholesterol Biosynthesis
BMP4-Induced Suppression of Breast Cancer Metastasis Is Associated with Inhibition of Cholesterol Biosynthesis Open
We reported previously that in preclinical models, BMP4 is a potent inhibitor of breast cancer metastasis and that high BMP4 protein levels predict favourable patient outcomes. Here, we analysed a breast cancer xenograft with or without en…
View article: Supplementary Figure S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S1 shows the association of BMP4 expression with tumour aggressiveness and with metastasis-free survival
View article: Supplementary Table S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
PCR primers
View article: Data from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Data from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Metastasis is the major cause of death in patients with cancer; with no therapeutic cure, treatments remain largely palliative. As such, new targets and therapeutic strategies are urgently required. Here, we show that bone morphogenetic pr…
View article: Supplementary Figure S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S4 demonstrates a role for SMAD7 in mediating the inhibition of metastasis by BMP4.
View article: Supplementary Table S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
BMP4 and SMAD7 in clinical samples
View article: Supplementary Figure S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S2 shows the effect of BMP4 on the in vitro properties of tumour cells and response of tumours in vivo.
View article: Supplementary Figure S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S4 demonstrates a role for SMAD7 in mediating the inhibition of metastasis by BMP4.
View article: Supplementary Table S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Anoikis genes regulated by BMP4
View article: Supplementary Figure legends from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure legends from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Legends for the four supplementary figures.
View article: Supplementary Table S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
BMP4 expression in human breast cancer
View article: Supplementary Figure S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S3 shows that BMP4 does not alter migration or invasion in vitro and that BMP7 can also inhibit metastasis.
View article: Supplementary Figure S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S2 shows the effect of BMP4 on the in vitro properties of tumour cells and response of tumours in vivo.
View article: Supplementary Table S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Anoikis genes regulated by BMP4
View article: Data from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Data from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Metastasis is the major cause of death in patients with cancer; with no therapeutic cure, treatments remain largely palliative. As such, new targets and therapeutic strategies are urgently required. Here, we show that bone morphogenetic pr…
View article: Supplementary Table S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S4 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
BMP4 and SMAD7 in clinical samples
View article: Supplementary Methods from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Methods from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Supplementary methods
View article: Supplementary Figure legends from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure legends from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Legends for the four supplementary figures.
View article: Supplementary Table S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
PCR primers
View article: Supplementary Figure S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S3 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S3 shows that BMP4 does not alter migration or invasion in vitro and that BMP7 can also inhibit metastasis.
View article: Supplementary Table S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Table S2 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
BMP4 expression in human breast cancer
View article: Supplementary Methods from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Methods from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Supplementary methods
View article: Supplementary Figure S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis
Supplementary Figure S1 from Activation of Canonical BMP4-SMAD7 Signaling Suppresses Breast Cancer Metastasis Open
Figure S1 shows the association of BMP4 expression with tumour aggressiveness and with metastasis-free survival
View article: MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms
MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms Open
MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as being associated with poor prognosis in cancer, we investigated its contribution to mammary …
View article: Bone morphogenetic protein signaling in breast cancer progression
Bone morphogenetic protein signaling in breast cancer progression Open
Breast cancer is the most prevalent type of cancer amongst women worldwide. The mortality rate for patients with early-stage breast cancer has been decreasing, however, the 5-year survival rate for patients with metastatic disease remains …
View article: Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis Open
Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since …
View article: Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis
Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis Open
Breast cancer brain metastasis remains largely incurable. While several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since th…