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View article: Densities and Fertilizer Dosages based Study on the Development and Yield of Solanum procumbens Lour. in the Central Vietnam
Densities and Fertilizer Dosages based Study on the Development and Yield of Solanum procumbens Lour. in the Central Vietnam Open
Background: Solanum procumbens Lour. is a precious medicinal plant in Vietnam, effective in treating toothache, snakebites, bone pain, alcohol poisoning, especially liver detoxification and hepatitis diseases. The study was conducted in Ce…
View article: Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies Open
Misfolding, aggregation and deposition of α-synuclein (α-syn) are major pathologic characteristics of Parkinson’s disease (PD) and the related synucleinopathy, multiple system atrophy (MSA). The spread of α-syn pathology across brain regio…
View article: Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model Open
[This corrects the article DOI: 10.1371/journal.pone.0223435.].
View article: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model Open
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Poly…
View article: The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice
The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice Open
A growing body of experimental data suggests that microbes in the gut influence behavior and can alter brain physiology and neurochemistry. Although promising, researchers are only starting to understand the potential of the gut microbiota…
View article: Insights into bioavailability and microbial catabolism of grape polyphenols in mice using an efficient UPLC-Triple quadrupole-MS/MS method
Insights into bioavailability and microbial catabolism of grape polyphenols in mice using an efficient UPLC-Triple quadrupole-MS/MS method Open
Background: Polyphenol-rich foods, such as grape-derived products, contain a wide array of bioactive phenolic compounds. These phenolic compounds are promising chemo-preventative agents, which can be acquired naturally through diet. A sma…
View article: Polyphenolic Compounds Alter Stress‐Induced Patterns of Global DNA Methylation in Brain and Blood
Polyphenolic Compounds Alter Stress‐Induced Patterns of Global DNA Methylation in Brain and Blood Open
Scope Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress‐induced depression/anxiety phenotypes are coincidental with increased inflammatio…
View article: Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms
Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms Open
Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates.
View article: A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols
A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols Open
The development of a given botanical preparation for eventual clinical application requires extensive, detailed characterizations of the chemical composition, as well as the biological availability, biological activity, and safety profiles…
View article: The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans
The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans Open
Scope Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) respon…
View article: Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat
Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat Open
Scope The effect of diabetes on the pharmacokinetics, bioavailability and brain distribution of grape polyphenols and select metabolites was studied in the Zucker diabetic fatty (ZDF) rat model. Methods and results (ZDF) rats and their lea…
View article: Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders in Subjects with Prior History of Traumatic Brain Injury: Implications in Alzheimer’s Disease
Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders in Subjects with Prior History of Traumatic Brain Injury: Implications in Alzheimer’s Disease Open
Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer’s disease (AD) are also imp…
View article: In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy
In Silico Modeling of Novel Drug Ligands for Treatment of Concussion Associated Tauopathy Open
The objective of this study was to develop an in silico screening model for characterization of potential novel ligands from commercial drug libraries able to functionally activate certain olfactory receptors (ORs), which are members of th…
View article: Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease
Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease Open
Parkinson's disease (PD) is one of the most common movement disorders, and currently there is no effective treatment that can slow disease progression. Preserving and enhancing DA neuron survival is increasingly regarded as the most promis…