Lara Brunasso
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View article: γδ T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities
γδ T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities Open
Glioblastoma multiforme (GBM) is one of the most aggressive cancers, with limited treatment options due to its highly immunosuppressive microenvironment and resistance to conventional therapies. γδ T cells, known for their potent antitumor…
View article: Gamma Delta T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities
Gamma Delta T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities Open
Glioblastoma multiforme (GBM) is one of the most aggressive cancers, with limited treatment options due to its immunosuppressive microenvironment. γδ T cells, known for their potent antitumor activity and ability to recognize tumor antigen…
View article: Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy
Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy Open
View article: In Reply to the Letter to the Editor Regarding “Caregivers' Perspective and Burden of the End-of-Life Phase of Patients with Glioblastoma: A Multicenter Retrospective Study”
In Reply to the Letter to the Editor Regarding “Caregivers' Perspective and Burden of the End-of-Life Phase of Patients with Glioblastoma: A Multicenter Retrospective Study” Open
View article: The importance of the optic nerves unlocking during the resection of anterior skull base meningiomas for visual function preservation: surgical nuances and clinical outcome
The importance of the optic nerves unlocking during the resection of anterior skull base meningiomas for visual function preservation: surgical nuances and clinical outcome Open
View article: Integrated Neuropsychological Assessment In Patients Undergoing Neurosurgical And Endovascular Treatment for Cerebral Aneurysms: Results Of A Prospective Observational Study
Integrated Neuropsychological Assessment In Patients Undergoing Neurosurgical And Endovascular Treatment for Cerebral Aneurysms: Results Of A Prospective Observational Study Open
View article: Deep Vein Thrombosis in Elective Neurosurgery: Results of a Prospective Observational Study
Deep Vein Thrombosis in Elective Neurosurgery: Results of a Prospective Observational Study Open
View article: Correction to: Pre-treatment DTI markers: predicting clinical outcomes in microvascular decompression for classic trigeminal neuralgia– a systematic review
Correction to: Pre-treatment DTI markers: predicting clinical outcomes in microvascular decompression for classic trigeminal neuralgia– a systematic review Open
View article: Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy.
Clinical outcomes and hemorrhagic or thromboembolic risks in decompressive craniectomy for patients taking antiplatelet or anticoagulant therapy. Open
Background Decompressive craniectomy (DC) is a critical surgical intervention for elevated intracranial pressure. However, the impact of preoperative antiplatelet or anticoagulant therapy on outcomes and complications remains unclear. Meth…
View article: Letter to the Editor. Management and long-term neurological outcomes of sdAVF
Letter to the Editor. Management and long-term neurological outcomes of sdAVF Open
View article: Caregivers' Perspective and Burden of the End-of-Life Phase of Patients with Glioblastoma: A Multicenter Retrospective Study
Caregivers' Perspective and Burden of the End-of-Life Phase of Patients with Glioblastoma: A Multicenter Retrospective Study Open
The end-of-life phases of patients with glioblastoma represent a critical factor that significantly affects not only the patient but also the caregiver's burden, caregiving tasks, and time. A multidisciplinary support program is needed to …
View article: Not Every Size Fits All: Surgical Corridors for Clival and Cervical Chordomas—A Systematic Review of the Literature and Illustrative Cases
Not Every Size Fits All: Surgical Corridors for Clival and Cervical Chordomas—A Systematic Review of the Literature and Illustrative Cases Open
Introduction. Clival chordomas represent a rare but clinically significant subset of skull base tumors, characterized by a locally aggressive nature and a location in proximity to vital neurovascular structures. Surgical resection, often c…
View article: Nuclear medicine imaging modalities to detect incidentalomas and their impact on patient management: a systematic review
Nuclear medicine imaging modalities to detect incidentalomas and their impact on patient management: a systematic review Open
View article: Infratentorial Relapsing Neuroglial Tumors in Adults: Management and Unsolved Issues—A Systematic Review
Infratentorial Relapsing Neuroglial Tumors in Adults: Management and Unsolved Issues—A Systematic Review Open
(1) Background: Gangliogliomas are rare tumors accounting for about 0.4% of all central nervous system tumors. They are usually located in the temporal lobes of children and young adults, though such tumors in the infratentorial region and…
View article: The Use of Intraoperative Microvascular Doppler in Vascular Neurosurgery: Rationale and Results—A Systematic Review
The Use of Intraoperative Microvascular Doppler in Vascular Neurosurgery: Rationale and Results—A Systematic Review Open
Surgical treatment of neurovascular lesions like intracranial aneurysms, arteriovenous malformations and arteriovenous dural fistulas is still associated with high morbidity. Several recent studies are providing increasing insights into re…
View article: Improving mixed-reality neuronavigation with blue-green light: a comparative multimodal laboratory study
Improving mixed-reality neuronavigation with blue-green light: a comparative multimodal laboratory study Open
OBJECTIVE This study aimed to rigorously assess the accuracy of mixed-reality neuronavigation (MRN) in comparison with magnetic neuronavigation (MN) through a comprehensive phantom-based experiment. It introduces a novel dimension by exami…
View article: The role of extended reality in eloquent area lesions: a systematic review
The role of extended reality in eloquent area lesions: a systematic review Open
OBJECTIVE The surgical approach to lesions near eloquent areas continues to represent a challenge for neurosurgeons, despite all of the sophisticated tools currently used. The goal of surgery in eloquent areas is to maintain a good oncofun…
View article: An Insight into the Prospects and Drawbacks of Stem Cell Therapy for Spinal Cord Injuries: Ongoing Trials and Future Directions
An Insight into the Prospects and Drawbacks of Stem Cell Therapy for Spinal Cord Injuries: Ongoing Trials and Future Directions Open
Spinal cord injury (SCI) is a devastating neurological disorder that has a substantial detrimental impact on a person’s quality of life. The estimated global incidence of SCI is 40 to 80 cases per million people and around 90% of cases are…
View article: The Role of Augmented Reality Neuronavigation in Transsphenoidal Surgery: A Systematic Review
The Role of Augmented Reality Neuronavigation in Transsphenoidal Surgery: A Systematic Review Open
In the field of minimally invasive neurosurgery, microscopic transsphenoidal surgery (MTS) and endoscopic transsphenoidal surgery (ETS) have been widely accepted as a safe approach for pituitary lesions and, more recently, their indication…
View article: Corticocortical Evoked Potentials in Eloquent Brain Tumor Surgery. A Systematic Review
Corticocortical Evoked Potentials in Eloquent Brain Tumor Surgery. A Systematic Review Open
View article: Assessing the Training in Neurosurgery with the Implementation of VITOM-3D Exoscope: Learning Curve on Experimental Model in Neurosurgical Practice
Assessing the Training in Neurosurgery with the Implementation of VITOM-3D Exoscope: Learning Curve on Experimental Model in Neurosurgical Practice Open
(1) Background: Innovation and continuous demand in the field of visual enhancing technologies and video streaming have led to the discovery of new systems capable of improving visualization and illumination of the surgical field. The exos…
View article: The Role of Aquaporins in Epileptogenesis—A Systematic Review
The Role of Aquaporins in Epileptogenesis—A Systematic Review Open
Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water …
View article: Diffuse idiopathic skeletal hyperostosis: A functional enemy of vertebral stability – Case series and surgical consideration of craniovertebral junction involvement
Diffuse idiopathic skeletal hyperostosis: A functional enemy of vertebral stability – Case series and surgical consideration of craniovertebral junction involvement Open
Context: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier’s syndrome may reduce vertebral mobility, thus affecting the stability of adjacent vertebral segments and promoting spinal stenosis, vertebral dislocation, and unstable …
View article: The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication
The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication Open
View article: Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma
Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma Open
View article: Flow diversion for indirect carotid-cavernous fistula: Still an off-label indication?
Flow diversion for indirect carotid-cavernous fistula: Still an off-label indication? Open
Background: Flow diversion (FD) is an established treatment for large or giant wide-necked unruptured intracranial aneurysms. In the past few years, the use of flow diverter devices was extended to several other “off-label” indications, in…
View article: Correlation between “Snake-Eyes” Sign and Role of Surgery with a Focus on Postoperative Outcome: A Systematic Review
Correlation between “Snake-Eyes” Sign and Role of Surgery with a Focus on Postoperative Outcome: A Systematic Review Open
(1) Background: The “snake-eyes” sign represents a unique finding characterized by bilateral hyperintense symmetric, circular, or ovoid foci on T2-weighted MRI sequences in the anterior horn cells of the spinal cord. There are conflicting …
View article: Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery
Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery Open
Background: The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, marks a step forward the future diagnostic approach to these neoplasms. Alongside this, radiomics has experienced rap…
View article: The Impact of Single-Level ACDF on Neural Foramen and Disc Height of Surgical and Adjacent Cervical Segments: A Case-Series Radiological Analysis
The Impact of Single-Level ACDF on Neural Foramen and Disc Height of Surgical and Adjacent Cervical Segments: A Case-Series Radiological Analysis Open
Background: ACDF has become one of the established procedures for the surgical treatment of symptomatic cervical spondylosis, showing excellent clinical results and effective improvements in neural functions and neck pain relief. The main …
View article: Cortical Reorganization in Cervical Spondylotic Myelopathic Patients Undergoing Cervical Surgery. A Functional Pilot Study
Cortical Reorganization in Cervical Spondylotic Myelopathic Patients Undergoing Cervical Surgery. A Functional Pilot Study Open