Lara De Tomasi
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View article: The upregulation of K<sup>+</sup> and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells
The upregulation of K<sup>+</sup> and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells Open
Spiral ganglion neurons (SGNs) are primary sensory afferent neurons that relay acoustic information from the cochlear inner hair cells (IHCs) to the brainstem. The response properties of different SGNs diverge to represent a wide range of …
View article: BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing
BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing Open
Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synapti…
View article: A critical period of prehearing spontaneous Ca <sup>2+</sup> spiking is required for hair‐bundle maintenance in inner hair cells
A critical period of prehearing spontaneous Ca <sup>2+</sup> spiking is required for hair‐bundle maintenance in inner hair cells Open
View article: Corrigendum: Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea
Corrigendum: Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea Open
[This corrects the article DOI: 10.3389/fnmol.2020.00083.].
View article: Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells
Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells Open
Key points Age‐related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age‐related change…
View article: Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea
Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals a Lmx1a Population in the Cochlea Open
In the mature cochlea, each inner hair cell (IHC) is innervated by multiple spiral ganglion neurons of type I (SGNI). SGNIs are morphologically and electro-physiologically diverse. Also, they differ in their susceptibility to noise insult.…
View article: Identification and implication of novel genes in the pathogenesis of congenital abnormalities of the kidney and urinary tract
Identification and implication of novel genes in the pathogenesis of congenital abnormalities of the kidney and urinary tract Open
Les anomalies congenitales des reins et des voies urinaires (CAKUT) regroupent un spectre d’anomalies du developpement renal incluant agenesies, hypoplasies et dysplasies. Elles constituent une cause majeure d’insuffisance renale chez l’en…
View article: Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice Open
View article: Targeted Exome Sequencing Identifies PBX1 as Involved in Monogenic Congenital Anomalies of the Kidney and Urinary Tract
Targeted Exome Sequencing Identifies PBX1 as Involved in Monogenic Congenital Anomalies of the Kidney and Urinary Tract Open
Congenital anomalies of the kidney and urinary tract (CAKUT) occur in three to six of 1000 live births, represent about 20% of the prenatally detected anomalies, and constitute the main cause of CKD in children. These disorders are phenoty…