Lara Feulner
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View article: Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution
Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution Open
Heart maturation and remodelling during the foetal and early postnatal period are critical for proper survival and growth of the foetus, yet our knowledge of the molecular processes involved are lacking for many cardiac cell types. To gain…
View article: Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue
Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue Open
Macrophages populate the embryo early in gestation, but their role in development is not well defined. In particular, specification and function of macrophages in intestinal development remain little explored. To study this event in the hu…
View article: Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1
Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1 Open
Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading t…
View article: Endocardial Regulation of Cardiac Development
Endocardial Regulation of Cardiac Development Open
The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been ma…