Lara M. Simpson
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View article: Mortality and Morbidity Among Individuals With Hypertension Receiving a Diuretic, ACE Inhibitor, or Calcium Channel Blocker
Mortality and Morbidity Among Individuals With Hypertension Receiving a Diuretic, ACE Inhibitor, or Calcium Channel Blocker Open
Importance The long-term relative risk of antihypertensive treatments with regard to mortality and morbidity is not well understood. Objective To determine the long-term posttrial risk of primary and secondary outcomes among trial particip…
View article: The 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drugs: post-trial analyses from ALLHAT–Medicare linked data
The 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drugs: post-trial analyses from ALLHAT–Medicare linked data Open
Purpose This study aimed to determine the 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drug use. Methods This is a post-trial passive follow-up study of Antihyperte…
View article: Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials Open
British Heart Foundation, Medical Research Council, Australian National Health and Medical Research Council.
View article: Risk of Developing Alzheimer's Disease and Related Dementias in ALLHAT Trial Participants Receiving Diuretic, ACE-Inhibitor, or Calcium-Channel Blocker with 18 Years of Follow-Up.
Risk of Developing Alzheimer's Disease and Related Dementias in ALLHAT Trial Participants Receiving Diuretic, ACE-Inhibitor, or Calcium-Channel Blocker with 18 Years of Follow-Up. Open
The risk of ADRD did not vary significantly by 3 antihypertensive drugs in ALLHAT trial participants with 18-years of follow-up. The risk of ADRD was significantly associated with age, gender, race/ethnicity, education, and history of vasc…
View article: Effects of Posttrial Antihypertensive Drugs on Morbidity and Mortality: Findings from 15-Year Passive Follow-Up after ALLHAT Ended
Effects of Posttrial Antihypertensive Drugs on Morbidity and Mortality: Findings from 15-Year Passive Follow-Up after ALLHAT Ended Open
Background. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) ended in 2002, but it is important to study its long-term outcomes during the posttrial period by incorporating posttrial antihypertensive med…
View article: Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker
Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker Open
Objectives This post-trial data linkage analysis was to utilize the data of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants linked with their Medicare data to examine the risk of hospitaliz…
View article: Sustained SBP control and long-term nursing home admission among Medicare beneficiaries
Sustained SBP control and long-term nursing home admission among Medicare beneficiaries Open
Objectives: Sustaining SBP control reduces the risk for cardiovascular events that impair function but its association with nursing home admission has not been well studied. Methods: We conducted an analysis of sustained SBP control and lo…
View article: A Phase <scp>II</scp> study of autologous mesenchymal stromal cells and c‐kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the <scp>CCTRN CONCERT‐HF</scp> trial
A Phase <span>II</span> study of autologous mesenchymal stromal cells and c‐kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the <span>CCTRN CONCERT‐HF</span> trial Open
Aims CONCERT‐HF is an NHLBI‐sponsored, double‐blind, placebo‐controlled, Phase II trial designed to determine whether treatment with autologous bone marrow‐derived mesenchymal stromal cells (MSCs) and c‐kit positive cardiac cells (CPCs), g…
View article: Association of Sustained Blood Pressure Control with Lower Risk for High-Cost Multimorbidities Among Medicare Beneficiaries in ALLHAT
Association of Sustained Blood Pressure Control with Lower Risk for High-Cost Multimorbidities Among Medicare Beneficiaries in ALLHAT Open
View article: Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker
Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker Open
Objectives This post-trial data linkage analysis was to utilize the data of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants linked with their Medicare data to examine the risk of hospitaliz…
View article: Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients
Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients Open
View article: Association of Sustained Blood Pressure Control with Multimorbidity Progression Among Older Adults
Association of Sustained Blood Pressure Control with Multimorbidity Progression Among Older Adults Open
BACKGROUND/OBJECTIVES Due to the high costs and excess mortality associated with multimorbidity, there is a need to develop approaches for delaying its progression. High blood pressure (BP) is a common chronic condition and a risk factor f…
View article: The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Open
Objectives: Gout is a common complication of blood pressure management and a frequently cited cause of medication nonadherence. Little trial evidence exists to inform antihypertensive selection with regard to gout risk. Methods: The Antihy…
View article: Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults
Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults Open
Hypertension treatment has been implicated in falls, syncope, and orthostatic hypotension (OH), common events among older adults. Whether the choice of antihypertensive agent influences the risk of falls, syncope, and OH in older adults is…
View article: Sustained blood pressure control and coronary heart disease, stroke, heart failure, and mortality: An observational analysis of ALLHAT
Sustained blood pressure control and coronary heart disease, stroke, heart failure, and mortality: An observational analysis of ALLHAT Open
Achieving blood pressure (BP) control is associated with lower cardiovascular disease (CVD) risk, but less is known about CVD risk associated with sustained BP control over time. This observational analysis of the Antihypertensive and Lipi…
View article: Pharmacologic Prevention of Incident Atrial Fibrillation
Pharmacologic Prevention of Incident Atrial Fibrillation Open
Background Although atrial fibrillation (AF) guidelines indicate that pharmacological blockade of the renin–angiotensin system may be considered for primary AF prevention in hypertensive patients, previous studies have yielded conflicting …
View article: Kidney function of transfused children with sickle cell anemia: Baseline data from the TWiTCH study with comparison to non‐transfused cohorts
Kidney function of transfused children with sickle cell anemia: Baseline data from the TWiTCH study with comparison to non‐transfused cohorts Open
The phase III multicenter clinical trial TWiTCH (NCT See Appendix for list of investigators) enrolled children with sickle cell anemia (SCA), who had previous abnormal transcranial Doppler ultrasound velocities (TCD V) and were receiving c…
View article: Electrocardiographic Left Ventricular Hypertrophy Predicts Cardiovascular Morbidity and Mortality in Hypertensive Patients: The ALLHAT Study
Electrocardiographic Left Ventricular Hypertrophy Predicts Cardiovascular Morbidity and Mortality in Hypertensive Patients: The ALLHAT Study Open
BACKGROUND Electrocardiographic (ECG) left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular (CV) morbidity and mortality. However, the predictive value of ECG LVH in treated hypertensive patients remains unclear. METHO…
View article: Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease
Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease Open
Background: Atherosclerotic peripheral artery disease affects 8% to 12% of Americans >65 years of age and is associated with a major decline in functional status, increased myocardial infarction and stroke rates, and increased risk of isch…
View article: Influence of Prevalent and Incident Atrial Fibrillation on Post-Trial Major Events in ALLHAT
Influence of Prevalent and Incident Atrial Fibrillation on Post-Trial Major Events in ALLHAT Open
View article: The Association Between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure
The Association Between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure Open
Low adherence to antihypertensive medication has been hypothesized to increase visit-to-visit variability (VVV) of blood pressure (BP). We assessed the association between antihypertensive medication adherence and VVV of BP in the Antihype…
View article: Visit-to-Visit Variability of BP and CKD Outcomes
Visit-to-Visit Variability of BP and CKD Outcomes Open
Higher visit-to-visit variability of BP is associated with higher risk of renal outcomes independent of mean BP.
View article: The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials
The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials Open
In primary- and secondary-prevention trials, statins modestly reduced the risks of non-fatal HF hospitalization and a composite of non-fatal HF hospitalization and HF death with no demonstrable difference in risk reduction between those wh…