Lara Marcuse
YOU?
Author Swipe
View article: Spatio-Temporal Attention Network for Epileptic Seizure Prediction
Spatio-Temporal Attention Network for Epileptic Seizure Prediction Open
In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (STAN) for accurate predictions of onset of seizures for Epilepsy pat…
View article: Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy Open
View article: Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study Open
Objective We investigated whether complete blood count (CBC) analyses during intensive care unit stay could predict 12‐month outcomes in patients with cryptogenic febrile infection–related epilepsy syndrome (FIRES), a subset of new‐onset r…
View article: Corrigendum to ‘The thalamus: Structure, function, and neurotherapeutics’
Corrigendum to ‘The thalamus: Structure, function, and neurotherapeutics’ Open
View article: Seizures and stigmas: Double burden on transgender health
Seizures and stigmas: Double burden on transgender health Open
View article: The thalamus: Structure, function, and neurotherapeutics
The thalamus: Structure, function, and neurotherapeutics Open
The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of …
View article: Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus
Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus Open
Meditation is an accessible mental practice associated with emotional regulation and well-being. Loving-kindness meditation (LKM), a specific subtype of meditative practice, involves focusing one’s attention on thoughts of well-being for o…
View article: Intracranial substrates of meditation-induced neuromodulation in amygdala and hippocampus
Intracranial substrates of meditation-induced neuromodulation in amygdala and hippocampus Open
Meditation is an accessible mental practice associated with emotional regulation and well-being. Loving-kindness meditation (LKM), a specific sub-type of meditative practice, involves focusing one’s attention on thoughts of well-being for …
View article: Elevated phase amplitude coupling as a depression biomarker in epilepsy
Elevated phase amplitude coupling as a depression biomarker in epilepsy Open
View article: Segmentation and quantification of venous structures and perivascular spaces in the thalamus in epilepsy using 7 Tesla MRI
Segmentation and quantification of venous structures and perivascular spaces in the thalamus in epilepsy using 7 Tesla MRI Open
Background and purpose: Epilepsy is a complex neurological disorder affecting 50 million people worldwide. Persistent seizures may correlate with neural network, microstructural, and vascular changes within the thalamus. These thalamic cha…
View article: Older adults with epilepsy and COVID-19: Outcomes in a multi-hospital health system
Older adults with epilepsy and COVID-19: Outcomes in a multi-hospital health system Open
View article: A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation Open
Introduction For drug resistant epilepsy patients who are either not candidates for resective surgery or have already failed resective surgery, neuromodulation is a promising option. Neuromodulatory approaches include responsive neurostimu…
View article: Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy
Mood and Anxiety Disorders and Suicidality in Patients With Newly Diagnosed Focal Epilepsy Open
In patients with newly diagnosed focal epilepsy, the prevalence of mood, anxiety disorders, and suicidality is higher than in the general population and comparable to those of patients with established epilepsy. Their recognition at the ti…
View article: Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
View article: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of which remain poorly defined in the human disease. In this study, we validated a method that…
View article: Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy
Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy Open
Introduction One-third of patients with epilepsy continue to have seizures despite antiepileptic medications. Some of these refractory patients may not be candidates for surgical resection primarily because the seizure onset zones (SOZs) i…
View article: Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19
Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19 Open
View article: Additional file 2 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 2 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 2: Table S1. Normalized RNA-seq gene expression data for all sorted nuclei, log-transformed (rld-normalized). A=Autopsy, TL; E=Epilepsy, TLE; N=NEUN+ FANS; O=OLIG2+ FANS; P=PAX6+ FANS.
View article: Quantification of brain age using high-resolution 7 tesla MR imaging and implications for patients with epilepsy
Quantification of brain age using high-resolution 7 tesla MR imaging and implications for patients with epilepsy Open
Morphological patterns suggestive of premature aging were observed in non-lesional epilepsy patients vs. controls and in high seizure frequency patients vs. low frequency patients. Modeling brain age with 7T MRI may provide a sensitive ima…
View article: Additional file 6 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 6 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 6: Table S5. Sequencing and mapping quality control metrics of single cell RNA-seq data from five independent TLE samples.
View article: Additional file 3 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 3 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 3: Table S2. Differential expression, TLE vs. TL, nuclear RNA-seq datasets for astrocyte, OPC, and neuronal FANS populations, with annotation of dysregulated genes unique to each cell type.
View article: Additional file 5 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 5 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 5: Table S4. Functional enrichment analyses of differentially expressed genes for each nuclei cell type, TLE vs. TL, generated using HOMER.
View article: Additional file 4 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 4 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 4: Table S3. Functional enrichment analyses of differentially expressed genes for each nuclei cell type, TLE vs. TL, generated using DAVID.
View article: Additional file 8 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Additional file 8 of High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy Open
Additional file 8: Table S6. List of top 50 cluster-defining genes in Seurat for main object integrated TLE analysis in Fig. 4a, subclustered glia object TLE analysis in Fig. 4b, and main object TL+TLE integrated analysis in Fig. 5a.
View article: Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs
Detection of Hippocampal Subfield Asymmetry at 7T With Automated Segmentation in Epilepsy Patients With Normal Clinical Strength MRIs Open
While the etiology of hippocampal sclerosis (HS) in epilepsy patients remains unknown, distinct phenotypes of hippocampal subfield atrophy have been associated with different clinical presentations and surgical outcomes. The advent of nove…
View article: Deep Learning of Simultaneous Intracranial and Scalp EEG for Prediction, Detection, and Lateralization of Mesial Temporal Lobe Seizures
Deep Learning of Simultaneous Intracranial and Scalp EEG for Prediction, Detection, and Lateralization of Mesial Temporal Lobe Seizures Open
In people with drug resistant epilepsy (DRE), seizures are unpredictable, often occurring with little or no warning. The unpredictability causes anxiety and much of the morbidity and mortality of seizures. In this work, 102 seizures of mes…
View article: Teaching NeuroImage: Human Polymerase Gamma Gene ( <i>POLG</i> ) Disorder Presenting as Refractory Status Epilepticus
Teaching NeuroImage: Human Polymerase Gamma Gene ( <i>POLG</i> ) Disorder Presenting as Refractory Status Epilepticus Open
A 31-year-old woman with severe childhood-onset dysmotility syndrome was admitted for encephalopathy and seizures. Video EEG demonstrated electrographic seizures of multifocal onset refractory to multiple antiseizure medications (figure 1,…
View article: Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone
Brief potentially ictal rhythmic discharges and paroxysmal fast activity as scalp electroencephalographic biomarkers of seizure activity and seizure onset zone Open
Objective The electroencephalographic (EEG) terms “brief potentially ictal rhythmic discharges” (BIRDs) and “paroxysmal fast activity” (PFA) are considered distinct entities; however, their definitions overlap, and they may have similar cl…
View article: Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes
Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes Open
View article: Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy
Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy Open