Leigh Anne Eller
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View article: Epidemiology of Hepatitis B Virus Co-infection Among People Living with HIV in Four Countries in Sub-Saharan Africa
Epidemiology of Hepatitis B Virus Co-infection Among People Living with HIV in Four Countries in Sub-Saharan Africa Open
Background Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) share transmission routes and are associated with morbidity in sub-Saharan Africa. Understanding the prevalence and demographic predictors of HBV co-infection among …
View article: Primed B cells continue to undergo affinity maturation in people living with HIV-1 when ART is provided in acute infection 4109
Primed B cells continue to undergo affinity maturation in people living with HIV-1 when ART is provided in acute infection 4109 Open
Description Protective, high affinity antibodies develop via mutagenesis and an iterative selection process in germinal centers called affinity maturation. For highly variable pathogens such as HIV-1, understanding the kinetics of antibody…
View article: Vaccine Induced Seroreactivity Following Administration of ALVAC-HIV/AIDSVAX®B/E Identified by Common Anti-HIV Test Kits and Algorithms in Thailand
Vaccine Induced Seroreactivity Following Administration of ALVAC-HIV/AIDSVAX®B/E Identified by Common Anti-HIV Test Kits and Algorithms in Thailand Open
Vaccine-induced seroreactivity (VISR) was evaluated in RV306 and was shown to vary markedly (0–32.5%) among 6 HIV diagnostic tests and 84 algorithms. Our data show that selecting the SD Bioline HIV-1/2 assay and algorithms which exclude th…
View article: Bayesian estimation of HIV acquisition dates for prevention trials
Bayesian estimation of HIV acquisition dates for prevention trials Open
Accurate timing estimates of when participants acquire HIV in HIV prevention trials are necessary for determining antibody levels at acquisition. The Antibody-Mediated Prevention (AMP) Studies showed that a passively administered broadly n…
View article: Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor
Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor Open
Background Low HIV-1 infection level in the central memory CD4 + T cell subset is a hallmark of both non-progressive HIV infection and non-pathogenetic SIV infection in the natural hosts. However, an important gap in knowledge is whether C…
View article: High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa
High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa Open
Introduction Cases of spontaneous control of HIV‐1 can help define strategies to induce remission. Since the identification of viral control in the absence of treatment typically occurs after a prolonged period post‐HIV‐1 diagnosis, our kn…
View article: NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1
NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1 Open
We leveraged specimens from the RV217 prospective study that enrolled participants at high risk of HIV-1 acquisition to investigate how NK cells, conventional T cells, and unconventional T cells influence HIV-1 acquisition. We observed low…
View article: The vast majority of SARS-CoV-2 infections were asymptomatic in a clinic-based cohort of people with and without HIV in four African countries
The vast majority of SARS-CoV-2 infections were asymptomatic in a clinic-based cohort of people with and without HIV in four African countries Open
The vast majority of people with positive SARS-CoV-2 RT-PCR were asymptomatic. Universal screening may be needed to fully understand the epidemiology of SARS-CoV-2 and future outbreaks of similar respiratory viruses, capture early infectio…
View article: CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth
CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth Open
New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously cha…
View article: PREVENTION AND CONTROL OF CHRONIC DISEASES IN VULNERABLE POPULATIONS
PREVENTION AND CONTROL OF CHRONIC DISEASES IN VULNERABLE POPULATIONS Open
Chronic diseases such as diabetes, hypertension and cardiovascular diseases are prevalent in vulnerable populations, who often face difficulties in accessing adequate medical care. Primary care, especially family medicine, plays a central …
View article: Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype Open
View article: Seroprevalence and risk factors for Lassa virus infection in South-West and North-Central Nigeria: a community-based cross-sectional study
Seroprevalence and risk factors for Lassa virus infection in South-West and North-Central Nigeria: a community-based cross-sectional study Open
The LASV seroprevalence was comparable to that in other areas in Nigeria. Our findings corroborate those from other studies on the importance of limiting human exposure to rodents and focusing on behavioral factors such as poor hygiene pra…
View article: HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study
HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study Open
View article: Safety and Immunogenicity of an Accelerated Ebola Vaccination Schedule in People with and without Human Immunodeficiency Virus: A Randomized Clinical Trial
Safety and Immunogenicity of an Accelerated Ebola Vaccination Schedule in People with and without Human Immunodeficiency Virus: A Randomized Clinical Trial Open
The safety and immunogenicity of the two-dose Ebola vaccine regimen MVA-BN-Filo, Ad26.ZEBOV, 14 days apart, was evaluated in people without HIV (PWOH) and living with HIV (PLWH). In this observer-blind, placebo-controlled, phase 2 trial, h…
View article: A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1
A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1 Open
A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective H…
View article: Author response: A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1
Author response: A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1 Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract A productive HIV-1 infection i…
View article: Author Response: A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1
Author Response: A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1 Open
A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective H…
View article: A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1
A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1 Open
A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective H…
View article: A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1
A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1 Open
A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective H…
View article: A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1
A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1 Open
A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves into a complex mixture of variants during the lifetime of infection. An effective H…
View article: Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria
Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria Open
Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To bett…
View article: PA-384 Lassa fever vaccine trial preparedness: preliminary findings of a targeted community-based epidemiologic study in Nigeria
PA-384 Lassa fever vaccine trial preparedness: preliminary findings of a targeted community-based epidemiologic study in Nigeria Open
Background Developing a vaccine to prevent Lassa Fever (LF), caused by Lassa virus (LASV), is a World Health Organization priority. We describe preliminary findings of a LASV epidemiologic study in Nigeria to inform preparation for CEPI/ED…
View article: Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study
Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study Open
Institute of Human Virology, National Institutes of Health, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Thai Red Cross AIDS Research Centre, Gilead Sciences, Merck, and ViiV Healthcare.
View article: Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype Open
View article: Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype Open
Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, detection was not at the earliest stages of acute infection. Here, we identified an X4-tropi…
View article: Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial
Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial Open
View article: Early sexual debut is associated with drug use and decreased educational attainment among males and females in Kisumu County, Kenya
Early sexual debut is associated with drug use and decreased educational attainment among males and females in Kisumu County, Kenya Open
Differing global sociocultural contexts of sexual relationships influence age at first sexual intercourse with potentially long-lasting region-specific effects such as increased risk of contracting HIV and other sexually transmitted infect…
View article: The Association Between Heterosexual anal Intercourse and HIV Acquisition in Three Prospective Cohorts of Women
The Association Between Heterosexual anal Intercourse and HIV Acquisition in Three Prospective Cohorts of Women Open
View article: Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting
Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting Open
The CCR5 (R5) to CXCR4 (X4) coreceptor switch in natural HIV-1 infection is associated with faster progression to AIDS, but the underlying mechanisms remain unclear. The difficulty in capturing the earliest moment of coreceptor switch in v…
View article: Tracking Coreceptor Switch of the Transmitted/Founder HIV-1 Identifies Co-Evolution of HIV-1 Antigenicity, Coreceptor Usage and CD4 Subset Targeting: The RV217 Acute Infection Cohort Study
Tracking Coreceptor Switch of the Transmitted/Founder HIV-1 Identifies Co-Evolution of HIV-1 Antigenicity, Coreceptor Usage and CD4 Subset Targeting: The RV217 Acute Infection Cohort Study Open