Explanipedia

Life Expectancy Predicted by Decision-Analytic Models Evaluating Screening for Prostate, Lung, Breast, and Colorectal Cancer: A Systematic Review Focusing on Competing Mortality Risks Open

Christin Henning, Gaby Sroczynski, Lára R. Hallsson, Beate Jahn, Uwe Siebert , et al. · 2025

Background It is still a matter of debate whether a reduction in cancer-specific mortality due to cancer screening fully translates into a reduction in all-cause mortality and thus into a gain in life expectancy. Nevertheless, decision-ana…

Effective sample size for the Kaplan-Meier estimator: A valuable measure of uncertainty? Open

Toby Hackmann, Doranne Thomassen, Anne M. Stiggelbout, Saskia le Cessie, Hein Putter , et al. · 2025

Science communication during the COVID-19 pandemic: experiences, challenges and expectations from the perspective of scientists in Austria Open

Nina Lorenzoni, Lára R. Hallsson, Magdalena Flatscher‐Thöni, Lina Förster, Claudia Schusterschitz · 2025

The COVID-19 pandemic put science in the spotlight like no other event before, but also created room for uncertainties, misinformation, and speculation. We used a qualitative research design and conducted semi-structured interviews with 13…

Directed Acyclic Graphs in Decision-Analytic Modeling: Bridging Causal Inference and Effective Model Design in Medical Decision Making Open

Stijntje Dijk, Maurice N Korf, Jeremy A. Labrecque, Ankur Pandya, Bart S. Ferket , et al. · 2025

Decision-analytic models (DAMs) are essentially informative yet complex tools for solving questions in medical decision making. When their complexity grows, the need for causal inference techniques becomes evident as causal relationships b…

PP60 Enhancing Patient Empowerment: European Capacity Building Initiative And Curriculum Development In Health Technology Assessment Training Open

Milena Muehler, Silke Siebert, Petra Schnell‐Inderst, Susan Rossmann, Sibylle Puntscher , et al. · 2024

Introduction The new Regulation (EU) 2021/2282 on health technology assessment (HTAR) highlights the increasing importance of patient perspectives, emphasizing their crucial role in HTA. The European Capacity Building for Patients (EUCAPA)…

OP76 Cost-Effectiveness Of Offering Human Papillomavirus Self-Sampling To Non-Attendees Of Organized Primary Cervical Cancer Screening In Germany Open

Gaby Sroczynski, Lára R. Hallsson, Milena Muehler, Peter Hillemanns, Matthias Jentschke , et al. · 2024

Introduction In Germany, organized cervical cancer screening with annual Papanicolaou (Pap) cytology for women age 20 to 34 years and three-yearly co-testing with human papillomavirus (HPV) and Pap for women as of age 35 years is standard.…

The EORTC QLU-C10D is a valid cancer-specific preference-based measure for cost-utility and health technology assessment in the Netherlands Open

Micha J. Pilz, Simon Seyringer, Lára R. Hallsson, Andrew Bottomley, Femke Jansen , et al. · 2024

The assessment of quality of care of patients with type 2 diabetes mellitus in a population-based cohort in the District of Landeck in Austria Open

Veronika Haslwanter, Ursula Rochau, Lára R. Hallsson, Uwe Siebert, Hans‐Robert Schönherr , et al. · 2024

Improving shared decision-making about cancer treatment through design-based data-driven decision-support tools and redesigning care paths: an overview of the 4D PICTURE project Open

Judith Rietjens, Ingeborg Griffioen, Jorge Sierra-Pérez, Gaby Sroczynski, Uwe Siebert , et al. · 2024

Background: Patients with cancer often have to make complex decisions about treatment, with the options varying in risk profiles and effects on survival and quality of life. Moreover, inefficient care paths make it hard for patients to par…

Colorectal cancer screening for persons with a positive family history Open

Alexander Crispin, Raphael Rehms, Sabine Hoffmann, Doris Lindoerfer, Lára R. Hallsson , et al. · 2023

The detection rates in this study corresponded to those of persons aged 55 to 59 in the current early detection program. Despite numerous problems in the performance of the study (inconsistencies in documentation, external performance of s…

Long‐term benefits and harms of early colorectal cancer screening in German individuals with familial cancer risk Open

Gaby Sroczynski, Lára R. Hallsson, Nikolai Mühlberger, Beate Jahn, Raphael Rehms , et al. · 2023

Individuals with a family history of colorectal cancer (CRC) may benefit from early screening with colonoscopy or immunologic fecal occult blood testing (iFOBT). We systematically evaluated the benefit‐harm trade‐offs of various screening …

Decision-analytic evaluation of the comparative effectiveness and cost-effectiveness of strategies to prevent breast and ovarian cancer in German women with BRCA-1/2 mutations Open

Lára R. Hallsson, Gaby Sroczynski, Jutta Engel, Uwe Siebert · 2023

Background Women with inherited mutations in the BRCA1 or BRCA2 genes have increased lifetime risks for developing breast and/or ovarian cancer and may develop these cancers around the age of 30 years. Therefore, prevention of breast and o…

Vergleich der Effektivität von multiplen dynamischen Behandlungsstrategien unter Nutzung der Target-Trial-Emulierung Open

Felicitas Kuehne, Lára R. Hallsson, Marjan Arvandi, Sibylle Puntscher, Beate Jahn , et al. · 2023

Table S4 from A Systematic Review on Cost-effectiveness Studies Evaluating Ovarian Cancer Early Detection and Prevention Strategies Open