Lari Pyöriä
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View article: Comparative evaluation of computational methods for reconstruction of human viral genomes
Comparative evaluation of computational methods for reconstruction of human viral genomes Open
The increasing availability of viral sequences has led to the emergence of many optimized viral genome reconstruction tools. Given that the number of new tools is steadily increasing, it is complex to identify functional and optimized tool…
View article: Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome
Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome Open
The viral intra-host genetic diversities and interactions with the human genome during decades of persistence remain poorly characterized. In this study, we analyzed the variability and integration sites of persisting viruses in nine organ…
View article: Multiple <scp>DNA</scp> Viruses and <scp>HPV</scp> Integration in Inverted Papilloma and Associated Sinonasal Carcinoma
Multiple <span>DNA</span> Viruses and <span>HPV</span> Integration in Inverted Papilloma and Associated Sinonasal Carcinoma Open
Objectives Sinonasal inverted papilloma (IP) has a locally destructive growth pattern, can relapse, and can undergo malignant transformation (IP‐associated sinonasal squamous cell carcinoma (IP‐SNSCC)). Human papillomaviruses (HPV)‐6 and ‐…
View article: Reactivation of a Transplant Recipient's Inherited Human Herpesvirus 6 and Implications to the Graft
Reactivation of a Transplant Recipient's Inherited Human Herpesvirus 6 and Implications to the Graft Open
Background The implications of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been linked to unfavorable clinical outcomes, an association between …
View article: Unmasking the tissue-resident eukaryotic DNA virome in humans
Unmasking the tissue-resident eukaryotic DNA virome in humans Open
Little is known on the landscape of viruses that reside within our cells, nor on the interplay with the host imperative for their persistence. Yet, a lifetime of interactions conceivably have an imprint on our physiology and immune phenoty…
View article: Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans
Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans Open
Background Little is known on the landscape of viruses that have taken residence within our cells, nor on the interplay with the host imperative for their persistence. Yet, a lifetime of interactions conceivably have an imprint on our phys…
View article: Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans
Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans Open
Background Little is known on the landscape of viruses that have taken residence within our cells, nor on the interplay with the host imperative for their persistence. However, a lifetime of interactions conceivably have an imprint on our …
View article: Survey of Viral Reactivations in Elite Athletes: A Case-Control Study
Survey of Viral Reactivations in Elite Athletes: A Case-Control Study Open
Exercise-induced immune perturbations have been proposed to increase susceptibility to viral infections. We investigated the replication of persisting viruses as indicators of immune function in elite cross-country skiers after ten months …
View article: The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas
The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas Open
BACKGROUND: The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background. OB…
View article: Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection
Persistence of Human Bocavirus 1 in Tonsillar Germinal Centers and Antibody-Dependent Enhancement of Infection Open
Human bocavirus 1 (HBoV1), a common pediatric respiratory pathogen, can persist in airway secretions for months hampering diagnosis. It also persists in tonsils, providing potential reservoirs for airway shedding, with the exact location, …
View article: A hybrid pipeline for reconstruction and analysis of viral genomes at multi-organ level
A hybrid pipeline for reconstruction and analysis of viral genomes at multi-organ level Open
Background Advances in sequencing technologies have enabled the characterization of multiple microbial and host genomes, opening new frontiers of knowledge while kindling novel applications and research perspectives. Among these is the inv…
View article: HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses
HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses Open
By adulthood, almost all humans become infected by at least one herpesvirus (HHV). The maladies inflicted by these microbes extend beyond the initial infection, as they remain inside our cells for life and can reactivate, causing severe di…