Larissa Matukas
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View article: ‘Raise the Bar’, a Canadian intervention to combat disparities in the recognition and management of iron deficiency: Development of the intervention, feasibility and implementation
‘Raise the Bar’, a Canadian intervention to combat disparities in the recognition and management of iron deficiency: Development of the intervention, feasibility and implementation Open
View article: Exploring variability in antibiograms: a cross-sectional study
Exploring variability in antibiograms: a cross-sectional study Open
Background Antibiograms are important tools for guiding empirical antimicrobial prescribing and monitoring antimicrobial resistance (AMR); however, there are challenges to their implementation and interpretation in practice. Variable forma…
View article: Invasive Group A Streptococcal Infection in Children, 1992-2023
Invasive Group A Streptococcal Infection in Children, 1992-2023 Open
Importance The resurgence of invasive group A streptococcal (iGAS) infections and progress in GAS vaccine development emphasize the importance of understanding current trends in the epidemiology of iGAS. Objective To describe the epidemiol…
View article: Canadian impact of CLSI aminoglycoside breakpoint changes for selected gram-negative bacteria
Canadian impact of CLSI aminoglycoside breakpoint changes for selected gram-negative bacteria Open
We evaluated the impact of recent revisions to the Clinical and Laboratory Standards Institute (CLSI) aminoglycoside breakpoints on susceptibility within Enterobacterales and Pseudomonas aeruginosa at a Canadian academic hospital. While th…
View article: Point-of-Care Testing Biosafety Decisions: An Investigation Summary Illustrating Current Decision-Making Process in Ontario, Canada
Point-of-Care Testing Biosafety Decisions: An Investigation Summary Illustrating Current Decision-Making Process in Ontario, Canada Open
Background Point-of-care testing (POCT) is increasingly being used in healthcare, including hospitals, and POCT-style tests are also used within some laboratories. The principles of biosafety, including risk assessment and containment of b…
View article: Wound swab quality grading is dependent on Gram smear screening approach
Wound swab quality grading is dependent on Gram smear screening approach Open
Superficial skin swab collections are inherently low-quality and may be of little clinical value due to their poor sensitivity and specificity. Clinical microbiology laboratories can use Gram smears to screen and differentiate higher and l…
View article: Burden of Severe Illness Associated With Laboratory-Confirmed Influenza in Adults Aged 50–64 Years, 2010–2011 to 2016–2017
Burden of Severe Illness Associated With Laboratory-Confirmed Influenza in Adults Aged 50–64 Years, 2010–2011 to 2016–2017 Open
Background Understanding the burden of influenza is necessary to optimize recommendations for influenza vaccination. We describe the epidemiology of severe influenza in 50- to 64-year-old residents of metropolitan Toronto and Peel region, …
View article: Author Correction: Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada
Author Correction: Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada Open
View article: Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada
Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada Open
View article: 1309. Incidence and Epidemiology of Invasive Pneumococcal Disease due to Serotype 3 in South-Central Ontario
1309. Incidence and Epidemiology of Invasive Pneumococcal Disease due to Serotype 3 in South-Central Ontario Open
Background In our population, the most common serotype (ST) of S. pneumoniae causing invasive pneumococcal disease (IPD) is now ST 3. We undertook an analysis of population based surveillance for IPD to examine the incidence and epidemiolo…
View article: Trouver, tester, « tracer » et isoler énergiquement pour battre la COVID-19
Trouver, tester, « tracer » et isoler énergiquement pour battre la COVID-19 Open
Au Canada, environ 300 personnes ont été déclarées positives au coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) chaque jour à la fin d'août 2020, ce qui correspond à environ 20 % de la moyenne quotidienne rapportée à la mi-…
View article: Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada
Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada Open
View article: Aggressively find, test, trace and isolate to beat COVID-19
Aggressively find, test, trace and isolate to beat COVID-19 Open
[See related research at [www.cmaj.ca/lookup/doi/10.1503/cmaj.201128][2]][2] About 300 people in Canada tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) per day at the end of August 2020, which is about 20% …
View article: Disseminated nocardiosis with multisite involvement in an immunocompetent patient
Disseminated nocardiosis with multisite involvement in an immunocompetent patient Open
KEY POINTS
A 73-year-old retired engineer presented to the emergency department with a 4-month history of transient left arm and leg paresthesias lasting minutes. His medical history included glaucoma and a 20 pack-year history of smoking,…
View article: COVID-19 Outbreak in an Urban Hemodialysis Unit
COVID-19 Outbreak in an Urban Hemodialysis Unit Open
View article: Evaluation of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and ClinPro Tools as a Rapid Tool for Typing Streptococcus pyogenes
Evaluation of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and ClinPro Tools as a Rapid Tool for Typing Streptococcus pyogenes Open
Background Timely strain typing of group A Streptococci (GAS) is necessary to guide outbreak recognition and investigation. We evaluated the use of (matrix-assisted laser desorption ionization time-of-flight mass spectrometry) combined wit…
View article: 160. Could Reducing Time to Bacterial Identification From Positive Blood Cultures Improve Outcomes in Bacteremic Patients?
160. Could Reducing Time to Bacterial Identification From Positive Blood Cultures Improve Outcomes in Bacteremic Patients? Open
Background Survival of patients with septic shock is dependent on the timing of effective antibiotic administration. The initial notification by the microbiology lab of a positive blood culture is a key factor in improving patient outcomes…
View article: Rapid detection of resistance to carbapenems and cephalosporins in Enterobacteriaceae using liquid chromatography tandem mass spectrometry
Rapid detection of resistance to carbapenems and cephalosporins in Enterobacteriaceae using liquid chromatography tandem mass spectrometry Open
Carbapenemase producing Enterobacteriaceae (CPE) are becoming a global healthcare concern. Current laboratory methods for the detection of CPE include screening followed by confirmatory phenotypic and genotypic tests. These processes would…
View article: Rapid Identification of Candida Species from Positive Blood Cultures by Use of the FilmArray Blood Culture Identification Panel
Rapid Identification of Candida Species from Positive Blood Cultures by Use of the FilmArray Blood Culture Identification Panel Open
View article: P159: Identifying the cause for inappropriate urine cultures in a Canadian urban academic emergency department
P159: Identifying the cause for inappropriate urine cultures in a Canadian urban academic emergency department Open
View article: Practical Guidance for Clinical Microbiology Laboratories: Implementing a Quality Management System in the Medical Microbiology Laboratory
Practical Guidance for Clinical Microbiology Laboratories: Implementing a Quality Management System in the Medical Microbiology Laboratory Open
SUMMARY This document outlines a comprehensive practical approach to a laboratory quality management system (QMS) by describing how to operationalize the management and technical requirements described in the ISO 15189 international standa…
View article: Can a smartphone app improve medical trainees’ knowledge of antibiotics?
Can a smartphone app improve medical trainees’ knowledge of antibiotics? Open
An antibiogram and treatment algorithm app increased knowledge of prescribing antimicrobials in the context of local antibiotic resistance patterns. These findings reinforce the notion that smartphone apps can be a useful and innovative me…
View article: Antimicrobial Stewardship in the Microbiology Laboratory: Impact of Selective Susceptibility Reporting on Ciprofloxacin Utilization and Susceptibility of Gram-Negative Isolates to Ciprofloxacin in a Hospital Setting
Antimicrobial Stewardship in the Microbiology Laboratory: Impact of Selective Susceptibility Reporting on Ciprofloxacin Utilization and Susceptibility of Gram-Negative Isolates to Ciprofloxacin in a Hospital Setting Open
The objective of this study was to determine the impact of selective susceptibility reporting on ciprofloxacin utilization and Gram-negative susceptibility to ciprofloxacin in a hospital setting. Historically at our institution, the microb…
View article: Cumulative Antimicrobial Susceptibility Data from Intensive Care Units at One Institution: Should Data Be Combined?
Cumulative Antimicrobial Susceptibility Data from Intensive Care Units at One Institution: Should Data Be Combined? Open
Cumulative susceptibility test data (CSTD) are used to guide empirical antimicrobial therapy and to track trends in antibiotic resistance. The Clinical and Laboratory Standards Institute recommends reporting CSTD at least annually and sets…
View article: Transmission of Verona Integron-Encoded Metallo-β-Lactamase-Producing Enterobacteriaceae Over a Two-Year Period Linked to Contaminated Drains
Transmission of Verona Integron-Encoded Metallo-β-Lactamase-Producing Enterobacteriaceae Over a Two-Year Period Linked to Contaminated Drains Open
Background.Over a 2-year period, among 8 patients colonized or infected with carbapenamase-producing Enterobacteriaceae (CPE), we identified 6 patients with Verona Integron-encoded metallo-β-Lactamase (VIM)-producing Enterobacter spp.We
View article: Lateral dissemination and inter-patient transmission of<i>bla</i><sub>KPC-3</sub>: role of a conjugative plasmid in spreading carbapenem resistance
Lateral dissemination and inter-patient transmission of<i>bla</i><sub>KPC-3</sub>: role of a conjugative plasmid in spreading carbapenem resistance Open
We describe intra- and inter-patient dissemination of blaKPC. The involvement of a clone related to the successful K. pneumoniae ST258 and the blaKPC-3 gene detected in an active Tn4401 transposon carried on a conjugative broad-host-range …
View article: Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study
Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study Open
Audit and feedback antimicrobial stewardship programs can lead to significant reductions in total antimicrobial use in the ICU setting. However, this effect may be context-dependent and further work is needed to determine the ingredients n…