Larissa Satiko Alcântara Sekimoto Matsuyama
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View article: Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways
Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways Open
Acral melanoma (AM) is an aggressive melanoma subtype with limited therapeutic options and poor outcomes. In non-European descent and admixed populations, like those residing in Latin America, AM accounts for a significant proportion of cu…
View article: The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types Open
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR–Cas9 screening in ten extensively profiled human uveal melanoma c…
View article: Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma
Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma Open
View article: High-resolution functional mapping of RAD51C by saturation genome editing
High-resolution functional mapping of RAD51C by saturation genome editing Open
Pathogenic variants in RAD51C confer an elevated risk of breast and ovarian cancer, while individuals homozygous for specific RAD51C alleles may develop Fanconi anemia. Using saturation genome editing (SGE), we functionally assess 9,188 un…
View article: Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma
Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma Open
Melanoma is a heterogenous malignancy with an unpredictable clinical course. Most patients who present in the clinic are diagnosed with primary melanoma, yet large‐scale sequencing efforts have focused primarily on metastatic disease. In t…
View article: Application of CRISPR-Cas9 to interrogate novel gene functions in cutaneous melanoma
Application of CRISPR-Cas9 to interrogate novel gene functions in cutaneous melanoma Open
\n Melanoma accounts for 3% of skin neoplasms and is the leading cause of death from skin disorders worldwide. The high mortality rate associated with this disease stems from the high capacity of melanoma patients to develop metastases and…
View article: Pioglitazone-Mediated Attenuation of Experimental Colitis Relies on Cleaving of Annexin A1 Released by Macrophages
Pioglitazone-Mediated Attenuation of Experimental Colitis Relies on Cleaving of Annexin A1 Released by Macrophages Open
Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases (IBDs) which burden health systems worldwide; available pharmacological therapies are limited and cost-intensive. Use of peroxisome proliferator activated-recep…
View article: Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing
Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing Open
The development of products for topical applications requires analyses of their skin effects before they are destined for the market. At present, the ban on animal use in several tests makes the search for in vitro models (such as artifici…