Explanipedia

Integrating blood eosinophils and exhaled nitric oxide (FeNO) in asthma diagnostic pathways for adults and children: the PROPULSION SANTÉ observational study with translational sub-studies (DIVE, DIVE2)—protocols Open

Morgane Gronnier, Sarah-Ève Lemieux, Felix-Antoine Vézina, Philippe Lachapelle, Dominic O. Cliché , et al. · 2025

Introduction Diagnosing asthma requires confirmation by bronchodilator reversibility (BDR) with or without bronchial provocation testing (BPT). Despite being needed in 80% of suspected cases following BDR, BPT access remains limited in Can…

Lung ultrasound in children with primary ciliary dyskinesia or cystic fibrosis Open

Noah Marzook, Alexander Sasha Dubrovsky, Karl Muchantef, David Zielinski, Larry C. Lands , et al. · 2024

Introduction Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are respiratory conditions requiring regular chest radiography (CXR) surveillance to monitor pulmonary disease. However, CXR is insensitive for lung disease in CF and P…

Card9 Broadly Regulates Host Immunity against Experimental Pulmonary Cryptococcus neoformans 52D Infection Open

Isabelle Angers, Wided Akik, Annie Beauchamp, Irah L. King, Larry C. Lands , et al. · 2024

The ubiquitous soil-associated fungus Cryptococcus neoformans causes pneumonia that may progress to fatal meningitis. Recognition of fungal cell walls by C-type lectin receptors (CLRs) has been shown to trigger the host immune response. Ca…

Virtual Physical Prehabilitation in Lung Transplant Candidates: A Proof-of-Concept Study Open

Nicholas Bourgeois, Larry C. Lands, Karina Prévost, Charles Poirier, Tania Janaudis‐Ferreira · 2024

This study aimed to preliminary test the effectiveness of 12-week virtual physical prehabilitation program followed by a maintenance phase. The main objective was to estimate the extent to which it affects exercise capacity, frailty, lower…

Reduced exercise capacity for muscle mass in adolescents living with obesity Open

Larry C. Lands, Juliano Colapelle, Julie St‐Pierre, Julius Erdstein · 2023

Background Adolescents living with obesity (AlwO) can have limited exercise capacity. Exercise capacity can be predicted by a 2-factor model comprising lung function and leg muscle function, but no study has looked at cycling leg muscle fu…

Table of Contents Open

Jeremy Gilbert, Phil McFarlane, James Mbbch, Susie Rph, Shannon M. Ruzycki , et al. · 2023

Research Milestone Forecasting in Cystic Fibrosis Open

Patrick Bodilly Kane, Félix Ratjen, J. Wallenburg, Larry C. Lands, Jonathan Kimmelman · 2023

Background: Cystic fibrosis (CF) has seen important breakthroughs in the last few years. Physicians, experts, and patients anticipate further treatment advances in the coming years.Methods: In October 2021, CF experts in the US and Canada …

A scoping review of mHealth monitoring of pediatric bronchial asthma before and during COVID-19 pandemic Open

Nurlan Dauletbaev, Zoe Sophie Oftring, Wided Akik, L Michaelis-Braun, J Korel , et al. · 2022

Re-opening the pediatric pulmonary function laboratory during the ongoing COVID-19 pandemic Open

Larry C. Lands · 2022

Lung Ultrasound in Pediatric Asthma - Characterizing Baseline Findings Outside of Acute Exacerbations Open

Noah Marzook, François Gagnon, Alexandre Déragon, David Zielinski, Adam J. Shapiro , et al. · 2021

Background: Lung ultrasound (LUS) has been shown to be an effective tool to rapidly diagnose certain causes of pediatric respiratory distress in the emergency department. However, very little is known about LUS findings in pediatric asthma…

Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF) Open

Helge Hebestreit, Susi Kriemler, Christian Schindler, Lothar Stein, Chantal Karila , et al. · 2021

Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. Objectives: To evaluate effects of a 12-month partially supervised PA intervention using motivational feedba…

Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD Open

Nafeez Syed, Min Hyung Ryu, Satvir S. Dhillon, Michele R. Schaeffer, Andrew H. Ramsook , et al. · 2021

Multidimensional scaling in Euclidean space of cytokine responses to document hyperinflammation in cystic fibrosis cells Open

Nurlan Dauletbaev, Wided Akik, Anne-Christin Hauschild, Thomas Damm, Assel Suleimenova , et al. · 2021

Introduction: Studies of hyperinflammation in Cystic Fibrosis (CF) frequently yield complex high-dimensional data due to comparisons of CF cells with wildtype or treated controls, and multiple cytokine analyses. This warrants utiliz…

Characterizing Pediatric Lung Ultrasound Findings During a Chemically-induced Bronchospasm Open

François Gagnon, Noah Marzook, Alexandre Déragon, Larry C. Lands, David Zielinski , et al. · 2021

Background: Lung ultrasound (LUS) has been shown to be a useful clinical tool in pediatrics. LUS has been well studied in other respiratory conditions, but very little is known about the LUS findings of asthma. Objectives: The primary obje…

Long-term bone mineral density changes and fractures in lung transplant recipients with cystic fibrosis Open

Gabrielle Durette, Valérie Jomphe, Nathalie J. Bureau, Charles Poirier, Pasquale Ferraro , et al. · 2020

Pediatric lung function testing during a pandemic: An international perspective Open

Nicole Beydon, Laura Gochicoa‐Rangel, Maude Jones, Larry C. Lands, Enrico Lombardi , et al. · 2020

The COVID pandemic has passed its first peak for now in many countries while some are still on the rise, with some facing a second wave of cases. Precautions and infection control measures for both pediatric and adult pulmonary function te…

The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4 Open

Mark J. Turner, Nurlan Dauletbaev, Larry C. Lands, John W. Hanrahan · 2020

Infection prevention and control in cystic fibrosis: One size fits all? Open

Larry C. Lands · 2020

Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis Open

A. Rad, Jennifer Landry, Liang Dong, Andrea Benedetti, Larry C. Lands , et al. · 2020

Brief report: International perspectives on the pediatric COVID‐19 experience Open

Özge Yılmaz, Laura Gochicoa‐Rangel, Hannah Blau, Ralph Epaud, Larry C. Lands , et al. · 2020

The 2019 novel coronavirus (SARS‐CoV‐2) is endangering human health worldwide; scarcity of published pediatric cases and current literature and the absence of evidence‐based guidelines necessitate international sharing of experience and pe…

Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis Open

Janannii Selvanathan, Shawn D. Aaron, Jenna Sykes, Katherine L. Vandemheen, J. Mark FitzGerald , et al. · 2020

Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele Open

Peter G. Middleton, Marcus Mall, Pavel Dřevı́nek, Larry C. Lands, Edward F. McKone , et al. · 2019

Elexacaftor-tezacaftor-ivacaftor was efficacious in patients with cystic fibrosis with Phe508del-minimal function genotypes, in whom previous CFTR modulator regimens were ineffective. (Funded by Vertex Pharmaceuticals; VX17-445-102 Clinica…

Comparison of oscillometry devices using active mechanical test loads Open

Ronald J. Dandurand, Jean‐Pierre Lavoie, Larry C. Lands, Zoltán Hantos · 2019

Noninvasiveness, low cooperation demand and the potential for detailed physiological characterisation have promoted the use of oscillometry in the assessment of lung function. However, concerns have been raised about the comparability of m…

Trends, Determinants, and Impact on Survival of Post-Lung Transplant Weight Changes: A Single-center Longitudinal Retrospective Study Open

Valérie Jomphe, Cécile Q.T. Nguyen, Gabrielle Durette, Miguel Chagnon, Basil Nasir , et al. · 2019

Background. Weight gain is commonly seen in lung transplant (LTx) recipients. Although previous studies have focused on weight changes at fixed time periods and relatively early after transplant, trends over time and long-term weight evolu…

Cardiopulmonary Exercise Testing Provides Additional Prognostic Information in Cystic Fibrosis Open

Helge Hebestreit, Erik H.J. Hulzebos, Jane E. Schneiderman, Chantal Karila, Steven R. Boas , et al. · 2018

CPET provides additional prognostic information to established predictors of death/lung transplantation in CF. High-risk patients may especially benefit from regular monitoring of exercise capacity and exercise counseling.

Nutritional Requirements of Lung Transplant Recipients: Challenges and Considerations Open

Valérie Jomphe, Larry C. Lands, Geneviève Mailhot · 2018

An optimal nutritional status is associated with better post-transplant outcomes and survival. Post-lung transplant nutrition management is however particularly challenging as lung recipients represent a very heterogeneous group of patient…

Effects of a partially supervised conditioning programme in cystic fibrosis: an international multi-centre randomised controlled trial (ACTIVATE-CF): study protocol Open

Helge Hebestreit, Larry C. Lands, Nancy Alarie, Jonathan Schaeff, Chantal Karila , et al. · 2018

ClinicalTrials.gov Identifier: NCT01744561 ; Registration date: December 6, 2012.

Nasal Nitric Oxide Levels in HIV Infection: A Cross-Sectional Study Open

Cecilia T. Costiniuk, Vikram Mehraj, Jean‐Pierre Routy, Cristina De Castro, Natale Wasef , et al. · 2018

Introduction . Low levels of nasal NO have been associated with increased propensity to rhinosinusitis and respiratory tract infections. Our objective was to describe nasal NO levels in HIV-infected individuals versus healthy controls and …

<i>CFTR</i>Genotype and Maximal Exercise Capacity in Cystic Fibrosis. A Cross-Sectional Study Open

Thomas Radtke, Helge Hebestreit, Sabina Gallati, Jane E. Schneiderman, Julia Braun , et al. · 2017

Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human skeletal muscle cells. Variations of CFTR dysfunction among patients with cystic fibrosis may be an important determinant of maximal exercise capacity in cyst…

Urine biomarkers of acute kidney injury in noncritically ill, hospitalized children treated with chemotherapy Open

Maya Sterling, Zubaida Al‐Ismaili, Kelly R. McMahon, Melissa Piccioni, Michael Pizzi , et al. · 2017

Background Cisplatin (Cis), carboplatin (Carb), and ifosfamide (Ifos) are common nephrotoxic chemotherapies. Biomarkers of tubular injury may allow for early acute kidney injury (AKI) diagnosis. Procedure We performed a two‐center (Canada,…

Larry C. Lands YOU? Author Swipe