Larry Culpepper
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View article: Standard Versus Enhanced Measurement-Based Care Effectiveness for Depression (EMBED): Protocol for a Cluster Randomized Implementation-Effectiveness Trial
Standard Versus Enhanced Measurement-Based Care Effectiveness for Depression (EMBED): Protocol for a Cluster Randomized Implementation-Effectiveness Trial Open
The results of this hybrid implementation-effectiveness cluster RCT will inform implementation of eMBC with WeChat mobile apps for patients with depression in other clinical settings in China and internationally.
View article: Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms
Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms Open
Aim Individuals with insomnia frequently have comorbid depression or anxiety. This study sought to provide a preliminary indication of the effects of lemborexant (LEM) in subjects treated for mild depression/anxiety symptoms. Methods E2006…
View article: A Retrospective Cross-Sectional Analysis of the Humanistic and Economic Burden of Bipolar I Disorder
A Retrospective Cross-Sectional Analysis of the Humanistic and Economic Burden of Bipolar I Disorder Open
These results demonstrate the substantial clinical and economic burdens associated with BP-I, and these negative impacts generally increase with BP-I severity. The study also suggests that despite not having the diagnosis of BP-I, burdens …
View article: The Humanistic and Economic Burden Associated with Major Depressive Disorder: A Retrospective Cross-Sectional Analysis
The Humanistic and Economic Burden Associated with Major Depressive Disorder: A Retrospective Cross-Sectional Analysis Open
These results quantify the significant and diverse burdens associated with MDD and prior MDD medication treatment failure.
View article: Health-Related Quality of Life and Healthcare Resource Use: Comparison of Patients with Bipolar I Disorder and Potentially Misdiagnosed Depression
Health-Related Quality of Life and Healthcare Resource Use: Comparison of Patients with Bipolar I Disorder and Potentially Misdiagnosed Depression Open
Background Bipolar I disorder (BP-I) is associated with a high humanistic and economic burden. Evidence suggests that BP-I is often misdiagnosed as major depressive disorder (MDD), but the unmet needs associated with BP-I misdiagnosis are …
View article: Minimal Effects of Cariprazine on Prolactin Levels in Bipolar Disorder and Schizophrenia
Minimal Effects of Cariprazine on Prolactin Levels in Bipolar Disorder and Schizophrenia Open
Treatment with cariprazine for schizophrenia or bipolar I disorder was associated with minimal effects on prolactin levels.
View article: Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial
Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial Open
Care transition support and post-discharge depression treatment can reduce unplanned hospital use with sufficient uptake of the RED-D intervention.
View article: Post Hoc Analysis of the Impact of Lemborexant on Patient-Reported Sleep and Insomnia Severity in Adults with Insomnia and Depression Histories
Post Hoc Analysis of the Impact of Lemborexant on Patient-Reported Sleep and Insomnia Severity in Adults with Insomnia and Depression Histories Open
Introduction The dual orexin receptor antagonist lemborexant (LEM) is approved in multiple countries including the United States, Japan, Canada, and Australia for insomnia treatment in adults. In phase 3 study E2006-G000-303 (Study 303; SU…
View article: EMBED Phase 2 Study Protocol v.1.4: A Cluster Randomized Controlled Trial of Enhanced versus Standard Measurement-Based Care Implementation for Depression
EMBED Phase 2 Study Protocol v.1.4: A Cluster Randomized Controlled Trial of Enhanced versus Standard Measurement-Based Care Implementation for Depression Open
Background: Measurement-based care (MBC) is an evidence-based practice that incorporates routine outcome assessment using validated rating scales to guide collaborative clinical decision-making. Although MBC results in improved outcomes fo…
View article: Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians
Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians Open
Ran Ha Hong,1 Jill K Murphy,1 Erin E Michalak,1 Trisha Chakrabarty,1 Zuowei Wang,2 Sagar V Parikh,3 Larry Culpepper,4 Lakshmi N Yatham,1 Raymond W Lam,1,* Jun Chen5,* 1Department of Psychiatry, University of British Columbia, Vancouver, Ca…
View article: Feasibility and Diagnostic Validity of the M-3 Checklist: A Brief, Self-Rated Screen for Depressive, Bipolar, Anxiety, and Post-Traumatic Stress Disorders in Primary Care
Feasibility and Diagnostic Validity of the M-3 Checklist: A Brief, Self-Rated Screen for Depressive, Bipolar, Anxiety, and Post-Traumatic Stress Disorders in Primary Care Open
PURPOSE Mood and anxiety disorders are the most common psychiatric conditions seen in primary care, yet they remain underdetected and undertreated. Screening tools can improve detection, but available instruments are limited by the number …
View article: 0543 Implementing Insomnia Care Paths for Older Adults and People with Dementia
0543 Implementing Insomnia Care Paths for Older Adults and People with Dementia Open
Introduction Despite the high prevalence of insomnia in older adults and those with dementia, screening and treatment remain inconsistent and suboptimal. Implementing a care path in a health system, though, is difficult. To determine what …
View article: 1185 Developing A Care Pathway For Insomnia In Older Adults And Adults With Dementia: Results Of A Consensus Meeting
1185 Developing A Care Pathway For Insomnia In Older Adults And Adults With Dementia: Results Of A Consensus Meeting Open
Introduction Insomnia among older adults and dementia patients carries a high public health burden. Yet, treatment is inconsistent or absent. Standardized, programmatic carepaths can be implemented in clinics/systems/communities to address…
View article: Methodological approaches to situational analysis in global mental health: a scoping review
Methodological approaches to situational analysis in global mental health: a scoping review Open
Global inequity in access to and availability of essential mental health services is well recognized. The mental health treatment gap is approximately 50% in all countries, with up to 90% of people in the lowest-income countries lacking ac…
View article: Stability, reliability, and validity of the THINC‐it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers
Stability, reliability, and validity of the THINC‐it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers Open
Objectives There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC‐it, a cognit…
View article: Enduring Truths
Enduring Truths Open
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.After the presidential election in the United States, many of us working at the interface of primary car…
View article: Recognizing Binge-Eating Disorder in the Clinical Setting
Recognizing Binge-Eating Disorder in the Clinical Setting Open
Overcoming primary care physician- and patient-related barriers is critical to accurately diagnose and appropriately treat BED. Primary care physicians should take an active role in the initial recognition and assessment of suspected BED b…
View article: Behavioral Health and Primary Care: A Status Report
Behavioral Health and Primary Care: A Status Report Open
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.It is 2016 and time to take stock and consider where we in primary care settings, and those in psychiatr…
View article: Understanding and Managing Cognition in the Depressed Patient
Understanding and Managing Cognition in the Depressed Patient Open
Cognition is a renewed area of clinical focus in major depressive disorder (MDD). Cognitive problems such as difficulty concentrating and making decisions are common symptoms of MDD, and while these symptoms improve as depressive symptoms …
View article: Moving Forward
Moving Forward Open
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.These are exciting times both in psychiatric research and at the interface of psychiatry and primary car…