Larry L. Luchsinger
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View article: “Connexin” the dots in hematopoietic stem cell potential
“Connexin” the dots in hematopoietic stem cell potential Open
View article: Mitofusin agonists enhances long-term engraftment and potency of HSC cultures <i>in vivo</i>
Mitofusin agonists enhances long-term engraftment and potency of HSC cultures <i>in vivo</i> Open
Umbilical cord blood (CBU) is a valuable source of hematopoietic stem cells (HSCs) due to its superior donor compatibility and lower incidence of graft-versus-host disease. However, its limited HSC content restricts its use in adult transp…
View article: Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling
Sexual dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling Open
The bone marrow (BM) niche is critical in regulating hematopoiesis, and sexual dimorphism and its underlying mechanism in the BM niche and its impact on hematopoiesis are not well understood. We show that male mice exhibited a higher abund…
View article: Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease
Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease Open
Disordered erythropoiesis is a feature of many hematologic diseases, including sickle cell disease (SCD). However, very little is known about erythropoiesis in SCD. Here, we show that although bone marrow (BM) erythroid progenitors and ery…
View article: Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood
Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood Open
Umbilical cord blood transplantation is a life-saving treatment for malignant and non-malignant hematologic disorders. It remains unclear how long cryopreserved units remain functional, and the length of cryopreservation is often used as a…
View article: Abstract 16 Insights into Highly Engraftable Hematopoietic Cells from 27-Year Cryopreserved Umbilical Cord Blood
Abstract 16 Insights into Highly Engraftable Hematopoietic Cells from 27-Year Cryopreserved Umbilical Cord Blood Open
Introduction Cord blood banking has consistently outpaced the utilization of cord blood units (CBUs). Thus, the average duration of cryopreservation among banked CBUs will likely continue to increase. It remains unclear how long cryopreser…
View article: Umbilical cord blood: an undervalued and underutilized resource in allogeneic hematopoietic stem cell transplant and novel cell therapy applications
Umbilical cord blood: an undervalued and underutilized resource in allogeneic hematopoietic stem cell transplant and novel cell therapy applications Open
Purpose of review The purpose of this review is to primarily discuss the unwarranted decline in the use of umbilical cord blood (UCB) as a source of donor hematopoietic stem cells (HSC) for hematopoietic cell transplantation (HCT) and the …
View article: High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19 Open
View article: Low Seroprevalence of SARS-CoV-2 in Rhode Island blood donors during may 2020 as determined using multiple serological assay formats
Low Seroprevalence of SARS-CoV-2 in Rhode Island blood donors during may 2020 as determined using multiple serological assay formats Open
Background Epidemic projections and public health policies addressing Coronavirus disease (COVID)-19 have been implemented without data reporting on the seroconversion of the population since scalable antibody testing has only recently bec…
View article: Hormetic endoplasmic reticulum stress in hematopoietic stem cells
Hormetic endoplasmic reticulum stress in hematopoietic stem cells Open
Purpose of review Hematopoietic stem cells (HSCs) possess the ability to regenerate over a lifetime in the face of extreme cellular proliferation and environmental stress. Yet, mechanisms that control the regenerative properties of HSCs re…
View article: Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and “Reopening”
Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays: Implications for controlling the epidemic and “Reopening” Open
Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national public health policies to limit coronavirus spread as well as “reopen” cities and states, are best infor…
View article: Characteristics of coronavirus disease 19 convalescent plasma donors and donations in the New York metropolitan area
Characteristics of coronavirus disease 19 convalescent plasma donors and donations in the New York metropolitan area Open
Background Convalescent plasma (CP) is an important initial treatment in pandemics and the New York (NY) metropolitan area is likely to remain a hotspot for collection and distribution of such units. This study reports characteristics of c…
View article: The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis Open
View article: Vaccine efficacy probable against COVID-19 variants
Vaccine efficacy probable against COVID-19 variants Open
The U.S. Food and Drug Administration (FDA) emergency use authorization of three vaccines, all of which have shown greater than 85% effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1–3), has provided the …
View article: High-resolution mapping and characterization of epitopes in COVID-19 patients
High-resolution mapping and characterization of epitopes in COVID-19 patients Open
Fine scale delineation of epitopes recognized by the antibody response to SARS-CoV-2 infection will be critical to understanding disease heterogeneity and informing development of safe and effective vaccines and therapeutics. The Serum Epi…
View article: Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Cohort of New York City Metro Blood Donors using Multiple SARS-CoV-2 Serological Assays: Implications for Controlling the Epidemic and “Reopening”
Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Cohort of New York City Metro Blood Donors using Multiple SARS-CoV-2 Serological Assays: Implications for Controlling the Epidemic and “Reopening” Open
Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national public health policies designed to limit the spread of the epidemic as well as “reopen” cities and state…
View article: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants Open
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2. Moreover, passively administered antibodies are among the most promising thera…
View article: Fluctuating High Throughput Serological Assay Results in Recurrent Convalescent Plasma Donors
Fluctuating High Throughput Serological Assay Results in Recurrent Convalescent Plasma Donors Open
The clinical and scientific communities rely on serology testing to analyze the degree of antibody-mediated immunity afforded to recovered patients from SARS-CoV-2 infection. Neutralizing antibodies present in COVID-19 convalescent plasma …
View article: Prevalence of antibodies to SARS-CoV-2 in healthy blood donors in New York
Prevalence of antibodies to SARS-CoV-2 in healthy blood donors in New York Open
Despite the high level of morbidity and mortality worldwide, there is increasing evidence for asymptomatic carriers of the novel coronavirus SARS-CoV-2. We analyzed blood specimens from 1,559 healthy blood donors, collected in the greater …
View article: Low Seroprevalence of SARS-CoV-2 in Rhode Island Blood Donors Determined Using Multiple Serological Assay Formats
Low Seroprevalence of SARS-CoV-2 in Rhode Island Blood Donors Determined Using Multiple Serological Assay Formats Open
Background: Epidemic projections and public health policies addressing Coronavirus disease (COVID)-19 have been implemented without data reporting on the seroconversion of the population since scalable antibody testing has only recently be…
View article: Author response: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Author response: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neutralizing antibodies elici…
View article: Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients
Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients Open
The development of neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following infection or vaccination is likely to be critical for the development of sufficient population immunity to dri…
View article: COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors Open
View article: A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2
A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2 Open
View article: Low Seroprevalence of SARS-CoV-2 in Rhode Island Blood Donors Determined using Multiple Serological Assay Formats
Low Seroprevalence of SARS-CoV-2 in Rhode Island Blood Donors Determined using Multiple Serological Assay Formats Open
Epidemic projections and public health policies addressing Coronavirus disease (COVID)-19 have been implemented without data reporting on the seroconversion of the population since scalable antibody testing has only recently become availab…
View article: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants Open
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2. Moreover, passively administered antibodies are among the most promising thera…
View article: COVID 19 Antibody Detection using Lateral Flow Assay Tests in a Cohort of Convalescent Plasma Donors
COVID 19 Antibody Detection using Lateral Flow Assay Tests in a Cohort of Convalescent Plasma Donors Open
Objective: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New Yo…
View article: Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID19 Patients
Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID19 Patients Open
The development of neutralizing antibodies (nAb) against SARS-CoV-2, following infection or vaccination, is likely to be critical for the development of sufficient population immunity to drive cessation of the COVID19 pandemic. A large num…
View article: Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro Open
View article: Source Data for "Harnessing hematopoietic stem cell low intracellular calcium improves their maintenance in vitro"
Source Data for "Harnessing hematopoietic stem cell low intracellular calcium improves their maintenance in vitro" Open
The source data for ~70 panels of data used to compute statistical significance in the paper.