Larry J. Young
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View article: Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles
Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles Open
Genetic variation in the oxytocin receptor gene ( Oxtr ) has been linked to differences in brain OXTR expression and long-term social bonds, but whether it shapes the moment-to-moment dynamics of early social interactions is unclear. Here …
View article: Development and characterisation of novel oxytocin analogues for PET imaging
Development and characterisation of novel oxytocin analogues for PET imaging Open
The oxytocin/oxytocin receptor (OT/OTR) signalling system is involved in socioemotional behaviours, garnering interest as a therapeutic target across multiple clinical conditions. Despite its potential, our limited understanding of how to …
View article: Nonlinear hippocampal coding of the pair-bonded partner in prairie voles
Nonlinear hippocampal coding of the pair-bonded partner in prairie voles Open
Neural representation of specific opposite-sex partners remains largely unexplored. Using monogamous prairie voles, we demonstrated that partner preference required the ventral hippocampus, in which 3–4 Hz oscillations were enhanced follow…
View article: Non-overlapping social and food reward representations in the basolateral amygdala
Non-overlapping social and food reward representations in the basolateral amygdala Open
The ability to consider and appraise positively valenced stimuli in the environment, such as food and social interaction, to guide appropriate action is important for survival of most animals. Several studies have compared how food and soc…
View article: The Relationship between Social Reward Behavior and Mesolimbic Dopamine Release
The Relationship between Social Reward Behavior and Mesolimbic Dopamine Release Open
Deficits in social behavior, such as reduced motivation and social avoidance, are key symptoms in several psychiatric disorders. Distinct modes of reward, such as drug and social, may rely on different dopamine release patterns in the meso…
View article: CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice
CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice Open
Oxytocin receptors (OTRs) within the extended amygdala and nucleus accumbens (NAc) have been implicated in modulating social behaviors, particularly following stress. The effects of OTR could be mediated by modulating the activity of pre-s…
View article: Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles
Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles Open
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumben…
View article: Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles
Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles Open
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (N…
View article: Male, but not female, oxytocin receptor knockout prairie voles (Microtus ochrogaster) show impaired consolation behavior
Male, but not female, oxytocin receptor knockout prairie voles (Microtus ochrogaster) show impaired consolation behavior Open
Prosocial behaviors, including empathetic consoling toward others, contribute to maintaining social groups and social connections between individuals in many mammalian species, including monogamous prairie voles (Microtus ochrogaster). Pra…
View article: Vocal recognition of partners by female prairie voles
Vocal recognition of partners by female prairie voles Open
Recognizing conspecifics is vital for differentiating mates, offspring, and social threats. Individual recognition is often reliant upon chemical or visual cues but can also be facilitated by vocal signatures in some species. In common lab…
View article: Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles
Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles Open
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (N…
View article: Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles
Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles Open
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumben…
View article: Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles
Different Roles of D1/D2 Medium Spiny Neurons in the Nucleus Accumbens in Pair Bond Formation of Male Mandarin Voles Open
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (N…
View article: Vocal recognition of partners by female prairie voles
Vocal recognition of partners by female prairie voles Open
Recognizing conspecifics is vitally important for differentiating kin, mates, offspring and social threats. 1 Although often reliant upon chemical or visual cues, individual recognition across the animal kingdom is also facilitated by uniq…
View article: Limbic oxytocin receptor expression alters molecular signaling and social avoidance behavior in female prairie voles (Microtus ochrogaster)
Limbic oxytocin receptor expression alters molecular signaling and social avoidance behavior in female prairie voles (Microtus ochrogaster) Open
Introduction The social defeat paradigm is the most representative animal model to study social anxiety disorder (SAD) and its underlying neuronal mechanisms. We have previously reported that defeat progressively reduces oxytocin receptors…
View article: Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis) Open
The neurohormones oxytocin (OT) and arginine vasopressin (AVP) are involved in social behaviors and psychiatric conditions. However, more research on nonhuman primates with complex social behaviors is needed. We studied two closely-related…
View article: Uncovering biologically relevant Autism subtypes using advanced machine learning techniques
Uncovering biologically relevant Autism subtypes using advanced machine learning techniques Open
Translation: The University of Toledo Journal of Medical Sciences is the online journal launched by the University of Toledo. Manuscripts will be considered on the understanding that they report original work and are not under consideratio…
View article: Oxytocin and women’s health in midlife
Oxytocin and women’s health in midlife Open
Menopause marks the cessation of fertility and the transition to post-reproductive years. Nearly 1 million US women experience menopause annually, but despite the significant impact it has on their physical and mental health, menopause has…
View article: Kin affiliation, socio-sexual and mating preference in the female Microtus ochrogaster in a multiple socio-sexual preference test
Kin affiliation, socio-sexual and mating preference in the female Microtus ochrogaster in a multiple socio-sexual preference test Open
Introduction The prairie vole ( Microtus ochrogaster ) is a socially monogamous species that, after cohabitation with mating, forms an enduring pair bond. It has been suggested that female prairie voles avoid mating with fathers and siblin…
View article: Natural variation in oxytocin receptor signaling causes widespread changes in brain transcription: a link to the natural killer gene complex
Natural variation in oxytocin receptor signaling causes widespread changes in brain transcription: a link to the natural killer gene complex Open
Oxytocin (OXT) is a highly conserved neuropeptide that modulates social cognition, and variation in its receptor gene ( Oxtr ) is associated with divergent social phenotypes. The cellular mechanisms connecting Oxtr genotype to social pheno…
View article: The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives
The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives Open
Love is a powerful emotional experience that is rooted in ancient neurobiological processes shared with other species that pair bond. Considerable insights have been gained into the neural mechanisms driving the evolutionary antecedents of…
View article: An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept
An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept Open
A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate betwee…