Lars Bosshard
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View article: Histopathology-based protein multiplex generation using deep learning
Histopathology-based protein multiplex generation using deep learning Open
View article: Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma Open
View article: Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia Open
View article: Probabilistic pathway-based multimodal factor analysis
Probabilistic pathway-based multimodal factor analysis Open
Motivation Multimodal profiling strategies promise to produce more informative insights into biomedical cohorts via the integration of the information each modality contributes. To perform this integration, however, the development of nove…
View article: Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer
Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer Open
Understanding the complex background of cancer requires genotype-phenotype information in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA-seq) on clinical samples from three ovarian cancer patients pres…
View article: Association of red cell omega-3 fatty acids, particularly EPA, with cognitive performance in atrial fibrillation
Association of red cell omega-3 fatty acids, particularly EPA, with cognitive performance in atrial fibrillation Open
Introduction Atrial fibrillation (AF) is associated with cognitive impairment and dementia. Whether or not omega-3 Fatty Acids (n-3 FAs) have neuroprotective effects is controversial. We therefore aimed to determine the correlation of n-3 …
View article: Advanced Diffusion-Weighted Imaging Sequences for Breast MRI: Comprehensive Comparison of Improved Sequences and Ultra-High B-Values to Identify the Optimal Combination
Advanced Diffusion-Weighted Imaging Sequences for Breast MRI: Comprehensive Comparison of Improved Sequences and Ultra-High B-Values to Identify the Optimal Combination Open
This study investigated the image quality and choice of ultra-high b-value of two DWI breast-MRI research applications. The study cohort comprised 40 patients (20 malignant lesions). In addition to s-DWI with two m-b-values (b50 and b800) …
View article: Quantitative Assessment of Iteratively Denoised 3D SPACE with Inner-Volume Excitation and Simultaneous Multi-Slice BLADE for Optimizing Female Pelvis Magnetic Resonance Imaging at 1.5 T
Quantitative Assessment of Iteratively Denoised 3D SPACE with Inner-Volume Excitation and Simultaneous Multi-Slice BLADE for Optimizing Female Pelvis Magnetic Resonance Imaging at 1.5 T Open
View article: scROSHI: robust supervised hierarchical identification of single cells
scROSHI: robust supervised hierarchical identification of single cells Open
Identifying cell types based on expression profiles is a pillar of single cell analysis. Existing machine-learning methods identify predictive features from annotated training data, which are often not available in early-stage studies. Thi…
View article: scROSHI - robust supervised hierarchical identification of single cells
scROSHI - robust supervised hierarchical identification of single cells Open
Identifying cell types based on expression profiles is a pillar of single cell analysis. Existing machine-learning methods identify predictive features from annotated training data, which are often not available in early-stage studies. Thi…
View article: Can Dynamic Contrast-enhanced MRI Contribute to Improved Assessment of Rectosigmoid Involvement in Deep Infiltrating Endometriosis?
Can Dynamic Contrast-enhanced MRI Contribute to Improved Assessment of Rectosigmoid Involvement in Deep Infiltrating Endometriosis? Open
csVIBE may provide a diagnostic benefit for surgical strategy selection through better delineation of the "mushroom cap sign."
View article: Dissection of the mutation accumulation process during bacterial range expansions
Dissection of the mutation accumulation process during bacterial range expansions Open
View article: Dissection of the mutation accumulation process during bacterial range expansions
Dissection of the mutation accumulation process during bacterial range expansions Open
Background Recent experimental work has shown that the evolutionary dynamics of bacteria expanding across space can differ dramatically from what we expect under well-mixed conditions. During spatial expansion, deleterious mutations can ac…
View article: Dissection of the mutation accumulation process during bacterial range expansions
Dissection of the mutation accumulation process during bacterial range expansions Open
Background Recent experimental work has shown that the evolutionary dynamics of bacteria expanding across space can differ dramatically from what we expect under well-mixed conditions. During spatial expansion, deleterious mutations can ac…
View article: Dissection of the mutation accumulation process during bacterial range expansions
Dissection of the mutation accumulation process during bacterial range expansions Open
Background Recent experimental work has shown that the evolutionary dynamics of bacteria expanding across space can differ dramatically from what we expect under well-mixed conditions. During spatial expansion, deleterious mutations can ac…
View article: Mutational and Selective Processes Involved in Evolution during Bacterial Range Expansions
Mutational and Selective Processes Involved in Evolution during Bacterial Range Expansions Open
Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mu…
View article: Genomic analysis of fast expanding bacteria reveals new molecular adaptive mechanisms
Genomic analysis of fast expanding bacteria reveals new molecular adaptive mechanisms Open
Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mu…
View article: Relaxed Selection During a Recent Human Expansion
Relaxed Selection During a Recent Human Expansion Open
Peischl et al. explore the way evolutionary forces shape genetic variability in expanding human populations. Over a few generations of separate evolution... Humans have colonized the planet through a series of range expansions, which deepl…
View article: Accumulation of Deleterious Mutations During Bacterial Range Expansions
Accumulation of Deleterious Mutations During Bacterial Range Expansions Open
Recent theoretical work suggested that deleterious mutations could accumulate during the range expansion of a species, negatively affecting its fitness. Recent theory predicts that the fitness of pioneer populations can decline when specie…
View article: Accumulation of deleterious mutations during bacterial range expansions
Accumulation of deleterious mutations during bacterial range expansions Open
Recent theory predicts that the fitness of pioneer populations can decline when species expand their range, due to high rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants. To test these pr…
View article: Relaxed selection during a recent human expansion
Relaxed selection during a recent human expansion Open
Humans have colonized the planet through a series of range expansions, which deeply impacted genetic diversity in newly settled areas and potentially increased the frequency of deleterious mutations on expanding wave fronts. To test this p…
View article: Genetic surfing in human populations: from genes to genomes
Genetic surfing in human populations: from genes to genomes Open
Genetic surfing describes the spatial spread and increase in frequency of variants that are not lost by genetic drift and serial migrant sampling during a range expansion. Genetic surfing does not modify the total number of derived alleles…
View article: Protection of<i>Erwinia amylovora</i>bacteriophage Y2 from UV-induced damage by natural compounds
Protection of<i>Erwinia amylovora</i>bacteriophage Y2 from UV-induced damage by natural compounds Open
Bacteriophages have regained much attention as biocontrol agents against bacterial pathogens. However, with respect to stability, phages are biomolecules and are therefore sensitive to a number of environmental influences. UV-irradiation c…