Lars C. Pedersen
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View article: Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break
Nonhomologous end-joining uses distinct mechanisms to repair each strand of a double strand break Open
View article: PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex Open
The rixosome is a large multisubunit complex that initiates RNA decay during critical nuclear transactions including ribosome assembly and heterochromatin maintenance. The overall architecture of the complex remains undefined because sever…
View article: End Processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis
End Processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis Open
Non-homologous end joining (NHEJ) is a major pathway of DNA double strand break (DSB) repair, capable of directly joining both damaged strands of DNA through the coordinated activities of repair factors that detect the termini, physically …
View article: Molecular basis for RNA discrimination by human DNA ligase 1
Molecular basis for RNA discrimination by human DNA ligase 1 Open
DNA ligase 1 (LIG1) finalizes DNA replication and repair by catalyzing the joining of DNA nicks. LIG1 is highly specific for DNA–DNA junctions over DNA–RNA junctions, discriminating strongly against a single ribonucleotide at the 5′ side o…
View article: Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase γ
Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase γ Open
The mitochondrial single-stranded DNA (ssDNA) binding protein, mtSSB or SSBP1, binds to ssDNA to prevent secondary structures of DNA that could impede downstream replication or repair processes. Clinical mutations in the SSBP1 gene have be…
View article: 110MO Statin use and early breast cancer survival: A Danish population-based cohort study using an emulated target trial approach
110MO Statin use and early breast cancer survival: A Danish population-based cohort study using an emulated target trial approach Open
Compelling evidence for the role of cholesterol in breast cancer metabolism suggests that cholesterol-lowering medications, such as statins, may improve breast cancer (BC) prognosis. We conducted a target trial to emulate a randomized tria…
View article: Structural and Functional Analysis of Heparosan Synthase 2 from <i>Pasteurella multocida</i> to Improve the Synthesis of Heparin
Structural and Functional Analysis of Heparosan Synthase 2 from <i>Pasteurella multocida</i> to Improve the Synthesis of Heparin Open
Heparin is a widely used drug to treat thrombotic disorders in hospitals. Heparosan synthase 2 from Pasteurella multocida (PmHS2) is a key enzyme used for the chemoenzymatic synthesis of heparin oligosaccharides. It has both activit…
View article: Semaglutide (Ozempic®) Use in Denmark 2018 Through 2023 ‒ User Trends and off-Label Prescribing for Weight Loss
Semaglutide (Ozempic®) Use in Denmark 2018 Through 2023 ‒ User Trends and off-Label Prescribing for Weight Loss Open
The use of semaglutide (Ozempic®) in Denmark has increased dramatically. Although not approved for weight loss without T2D, one-third of new users in 2022 did not have T2D. Conversely, most initiators with T2D had a clear medica…
View article: Heparan sulfate selectively inhibits the collagenase activity of cathepsin K
Heparan sulfate selectively inhibits the collagenase activity of cathepsin K Open
View article: Editorial: Heparan sulfate-binding proteins in health and disease
Editorial: Heparan sulfate-binding proteins in health and disease Open
EDITORIAL article Front. Mol. Biosci., 20 March 2024Sec. Glycoscience Volume 11 - 2024 | https://doi.org/10.3389/fmolb.2024.1386623
View article: Neutralizing IgG4 antibodies are a biomarker of sustained efficacy after peanut oral immunotherapy
Neutralizing IgG4 antibodies are a biomarker of sustained efficacy after peanut oral immunotherapy Open
View article: Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies
Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies Open
In peanut allergy, Arachis hypogaea 2 (Ara h 2) and Arachis hypogaea 6 (Ara h 6) are two clinically relevant peanut allergens with known structural and sequence homology and demonstrated cross-reactivity. We have previously utilized X-ray …
View article: DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining Open
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Author Response: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Author Response: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Heparan sulfate selectively inhibits the collagenase activity of cathepsin K
Heparan sulfate selectively inhibits the collagenase activity of cathepsin K Open
Cathepsin K (CtsK) is a cysteine protease with potent collagenase activity. CtsK is highly expressed by bone-resorbing osteoclasts and plays an essential role in bone remodeling. Although CtsK is known to bind heparan sulfate (HS), the str…
View article: Design of an Ara h 2 hypoallergen from conformational epitopes
Design of an Ara h 2 hypoallergen from conformational epitopes Open
Introduction Adverse reactions are relatively common during peanut oral immunotherapy. To reduce the risk to the patient, some researchers have proposed modifying the allergen to reduce IgE reactivity, creating a putative hypoallergen. Ana…
View article: Author Response: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Author Response: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Reviewer #2 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Reviewer #2 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Reviewer #1 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Reviewer #1 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase Open
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer. These studies were undertaken to evaluate whether t…
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Reviewer #2 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Reviewer #2 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Reviewer #1 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Reviewer #1 (Public Review): Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Heparan sulfate promotes TRAIL-induced tumor cell apoptosis
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis Open
TRAIL (TNF-related apoptosis-inducing ligand) is a potent inducer of tumor cell apoptosis through TRAIL receptors. While it has been previously pursued as a potential anti-tumor therapy, the enthusiasm subsided due to unsuccessful clinical…
View article: Increased 3- <i>O</i> -sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene <i>HS3ST1</i>
Increased 3- <i>O</i> -sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene <i>HS3ST1</i> Open
HS3ST1 is a genetic risk gene associated with Alzheimer’s disease (AD) and overexpressed in patients, but how it contributes to the disease progression is unknown. We report the analysis of brain heparan sulfate (HS) from AD and other tauo…
View article: Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies
Targeting heparan sulfate-protein interactions with oligosaccharides and monoclonal antibodies Open
Heparan sulfate-binding proteins (HSBPs) are structurally diverse extracellular and membrane attached proteins that interact with HS under normal physiological conditions. Interactions with HS offer an additional level of control over the …